{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T20:27:50Z","timestamp":1791404870498,"version":"4.3.3"},"reference-count":48,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2017,11,10]],"date-time":"2017-11-10T00:00:00Z","timestamp":1510272000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81270945"],"award-info":[{"award-number":["81270945"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2017,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Aim<\/jats:title><jats:p>Short bowel syndrome (SBS) is a common cause of intestinal failure and can be divided into three types depending on intestinal anatomy. Gut dysbiosis has been observed in pediatric SBS patients and is associated with impaired outcome. Little is known about the changes in gut microbiota of adult SBS patients. Therefore, we aim to characterize the fecal microbiota of adult patients with different types of SBS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Fifteen fecal samples from healthy controls and adult patients with type II or type III SBS were collected (five in each group). Fecal microbial compositions were determined by high\u2010throughput sequencing, and functional potential was predicted by Phylogenetic Investigation of Communities by Reconstruction of Unobserved States.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Bacterial <jats:italic>\u03b1<\/jats:italic>\u2010diversity significantly decreased in SBS patients and positively correlated to the remaining small bowel length. SBS II patients were enriched with Proteobacteria but deficient in Firmicutes and Bacteroidetes. Whereas <jats:italic>Lactobacillus<\/jats:italic> and <jats:italic>Prevotella<\/jats:italic> dominated the microbiomes of SBS III patients, commensal bacteria from Lachnospiraceae, Ruminococcaceae, and Bacteroidaceae declined in SBS patients. The parenteral nutrition duration of SBS patients was positively related to the proportion of Enterobacteriaceae but negatively related to <jats:italic>Lactobacillus<\/jats:italic>. Functional pathways of citrate cycle and branched\u2010chain and aromatic amino acid biosynthesis were abundant in SBS II patients, while functional profiles of pyrimidine and purine metabolism were dominant in SBS III patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Short bowel syndrome patients have a marked intestinal dysbiosis with type II SBS characterized by Proteobacteria and type III SBS featured by <jats:italic>Lactobacillus<\/jats:italic>, resulting in altered functional profiles of fecal microbiomes.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jgh.13806","type":"journal-article","created":{"date-parts":[[2017,4,20]],"date-time":"2017-04-20T03:18:51Z","timestamp":1492658331000},"page":"1949-1957","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":60,"title":["Fecal microbiota signatures of adult patients with different types of short bowel syndrome"],"prefix":"10.1111","volume":"32","author":[{"given":"Yuhua","family":"Huang","sequence":"first","affiliation":[{"name":"Intestinal Rehabilitation and Transplant Center, Jinling Hospital, School of Medicine Nanjing University  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feilong","family":"Guo","sequence":"additional","affiliation":[{"name":"Intestinal Rehabilitation and Transplant Center, Jinling Hospital, School of Medicine Nanjing University  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yousheng","family":"Li","sequence":"additional","affiliation":[{"name":"Intestinal Rehabilitation and Transplant Center, Jinling Hospital, School of Medicine Nanjing University  Nanjing China"},{"name":"Department of general surgery, Shanghai Ninth People's Hospital Shanghai JiaoTong University School of Medicine  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Wang","sequence":"additional","affiliation":[{"name":"Intestinal Rehabilitation and Transplant Center, Jinling Hospital, School of Medicine Nanjing University  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jieshou","family":"Li","sequence":"additional","affiliation":[{"name":"Intestinal Rehabilitation and Transplant Center, Jinling Hospital, School of Medicine Nanjing University  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,11,10]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11894-016-0511-3"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1067\/j.cpsurg.2011.10.002"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2015.01154"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clnu.2016.01.020"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0073140"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clnu.2016.04.009"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2014.02.032"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2012.01.035"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2014.01.052"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1177\/0148607115591216"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1177\/0148607115584388"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40168-015-0084-7"},{"key":"e_1_2_5_14_1","article-title":"Severe gut microbiota dysbiosis is associated with poor growth in patients with short bowel syndrome","author":"Piper HG","year":"2016","journal-title":"JPEN J. 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