{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T14:17:06Z","timestamp":1776089826370,"version":"3.50.1"},"reference-count":50,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2017,11,10]],"date-time":"2017-11-10T00:00:00Z","timestamp":1510272000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2017,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Aim<\/jats:title><jats:p>DA\u20109701, a newly developed prokinetic agent formulated with Pharbitis Semen and Corydalis Tuber, has been shown to effectively treat functional dyspepsia. Recently, it has also been suspected to improve gastrointestinal motor function. The aims of this study were to assess the effect of DA\u20109701 on colonic transit time (CTT) and symptoms of functional constipation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Thirty\u2010three patients with functional constipation based on the Rome III criteria were prospectively enrolled. The patients received 30\u2010mg DA\u20109701 three times a day for 24\u00a0days. CTT was estimated initially and at the end of treatment. Symptoms such as spontaneous bowel movements, straining, stool form, feeling of incomplete emptying and anorectal blockage, abdominal discomfort and pain, overall defecation satisfaction, and incidence of adverse events were also analyzed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Twenty\u2010seven patients completed the study. DA\u20109701 was associated with a significantly reduced CTT from 34.9\u00a0\u00b1\u00a017.6 to 23.7\u00a0\u00b1\u00a019.1\u00a0h (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.001). Segmental CTT also significantly decreased after treatment (right CTT: from 16.8 [0.0\u201328.8] to 6.0 [0.0\u201325.2] hours, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001; rectosigmoid transit time: from 13.2 [0.0\u201338.4] to 6.0 [0.0\u201333.6] hours, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.021). In addition, all constipation\u2010related subjective symptoms, including spontaneous bowel movement frequency, significantly improved compared with those before treatment. Serious adverse events did not occur.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>DA\u20109701 accelerates colonic transit and safely improves symptoms in patients with functional constipation. Therefore, we suggest that this novel agent could help to treat patients with this condition.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jgh.13807","type":"journal-article","created":{"date-parts":[[2017,4,21]],"date-time":"2017-04-21T21:52:45Z","timestamp":1492811565000},"page":"1943-1948","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["DA\u20109701 improves colonic transit time and symptoms in patients with functional constipation: A prospective study"],"prefix":"10.1111","volume":"32","author":[{"given":"Su Young","family":"Kim","sequence":"first","affiliation":[{"name":"Division of Gastroenterology, Department of Internal Medicine Gachon University  Incheon South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hyun Sun","family":"Woo","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Department of Internal Medicine Gachon University  Incheon South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kyoung Oh","family":"Kim","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Department of Internal Medicine Gachon University  Incheon South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sung Han","family":"Choi","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Department of Internal Medicine Gachon University  Incheon South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kwang An","family":"Kwon","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Department of Internal Medicine Gachon University  Incheon South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun\u2010Won","family":"Chung","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Department of Internal Medicine Gachon University  Incheon South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoon Jae","family":"Kim","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Department of Internal Medicine Gachon University  Incheon South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jung Ho","family":"Kim","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Department of Internal Medicine Gachon University  Incheon South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Su Ji","family":"Kim","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Department of Internal Medicine Gachon University  Incheon South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dong Kyun","family":"Park","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Department of Internal Medicine Gachon University  Incheon South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,11,10]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(93)90896-K"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004836-198910000-00008"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2007.03376.x"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.3122\/jabfm.2011.04.100272"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/MCG.0b013e318231fc64"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2014.74"},{"key":"e_1_2_6_8_1","first-page":"148","article-title":"Current issues on the treatment of chronic constipation","volume":"64","author":"Hong KS","year":"2014","journal-title":"J. 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