{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,9]],"date-time":"2026-08-09T17:26:48Z","timestamp":1786296408509,"version":"build-2736575974"},"reference-count":31,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2017,12,28]],"date-time":"2017-12-28T00:00:00Z","timestamp":1514419200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2018,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Aim<\/jats:title><jats:p>Little is known about the diagnostic value of hepatic steatosis index (HSI) and fatty liver index (FLI), as well as their link to metabolic syndrome in type 1 diabetes mellitus. We have screened the effectiveness of FLI and HSI in an observational pilot study of 40 patients with type 1 diabetes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>FLI and HSI were calculated for 201 patients with type 1 diabetes. Forty patients with FLI\/HSI values corresponding to different risk of liver steatosis were invited for liver magnetic resonance study. In\u2010phase\/opposed\u2010phase technique of magnetic resonance was used. Accuracy of indices was assessed from the area under the receiver operating characteristic curve.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Twelve (30.0%) patients had liver steatosis. For FLI, sensitivity was 90%; specificity, 74%; positive likelihood ratio, 3.46; negative likelihood ratio, 0.14; positive predictive value, 0.64; and negative predictive value, 0.93. For HSI, sensitivity was 86%; specificity, 66%; positive likelihood ratio, 1.95; negative likelihood ratio, 0.21; positive predictive value, 0.50; and negative predictive value, 0.92. Area under the receiver operating characteristic curve for FLI was 0.86 (95% confidence interval [0.72; 0.99]); for HSI 0.75 [0.58; 0.91]. Liver fat correlated with liver enzymes, waist circumference, triglycerides, and C\u2010reactive protein. FLI correlated with C\u2010reactive protein, liver enzymes, and blood pressure. HSI correlated with waist circumference and C\u2010reactive protein. FLI\u00a0\u2265\u00a060 and HSI\u00a0\u2265\u00a036 were significantly associated with metabolic syndrome and nephropathy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The tested indices, especially FLI, can serve as surrogate markers for liver fat content and metabolic syndrome in type 1 diabetes.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jgh.13814","type":"journal-article","created":{"date-parts":[[2017,5,2]],"date-time":"2017-05-02T17:27:26Z","timestamp":1493746046000},"page":"270-276","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":115,"title":["<i>Fatty liver index<\/i> and <i>hepatic steatosis index for prediction of<\/i> non\u2010alcoholic fatty liver disease in type 1 diabetes"],"prefix":"10.1111","volume":"33","author":[{"given":"Laura","family":"Svikl\u0101ne","sequence":"first","affiliation":[{"name":"Faculty of Medicine University of Latvia  Riga Latvia"},{"name":"Pauls Stradins Clinical University Hospital  Riga Latvia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evija","family":"Olmane","sequence":"additional","affiliation":[{"name":"Pauls Stradins Clinical University Hospital  Riga Latvia"},{"name":"Magnetic Resonance Center DiaMed  Riga Latvia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zane","family":"Dz\u0113rve","sequence":"additional","affiliation":[{"name":"Faculty of Medicine University of Latvia  Riga Latvia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K\u0101rlis","family":"Kup\u010ds","sequence":"additional","affiliation":[{"name":"Pauls Stradins Clinical University Hospital  Riga Latvia"},{"name":"Magnetic Resonance Center DiaMed  Riga Latvia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valdis","family":"P\u012br\u0101gs","sequence":"additional","affiliation":[{"name":"Faculty of Medicine University of Latvia  Riga Latvia"},{"name":"Pauls Stradins Clinical University Hospital  Riga Latvia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0448-8229","authenticated-orcid":false,"given":"Je\u013cizaveta","family":"Sokolovska","sequence":"additional","affiliation":[{"name":"Faculty of Medicine University of Latvia  Riga Latvia"},{"name":"Pauls Stradins Clinical University Hospital  Riga Latvia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,12,28]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-016-3944-1"},{"key":"e_1_2_6_3_1","article-title":"Nonobese fatty liver disease","author":"Kim D","year":"2016","journal-title":"Clin. 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