{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,4]],"date-time":"2026-02-04T16:43:22Z","timestamp":1770223402750,"version":"3.49.0"},"reference-count":19,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2017,12,28]],"date-time":"2017-12-28T00:00:00Z","timestamp":1514419200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2018,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Aim<\/jats:title><jats:p>Acute liver failure (ALF) is defined as acute liver injury (ALI) associated with coagulopathy. A follow\u2010up strategy for ALI and characterization of ALI patients with a risk of progressing to ALF have never been established. To establish predictive markers for progression from ALI to ALF, this study compared the clinical characteristics and laboratory data on the day of registration to data from a regional referral system of patients with ALI.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This prospective, observational study enrolled 365 consecutive patients with ALI\/ALF between 2007 and 2016. We evaluated 109 ALI patients, 27 of whom satisfied the ALF criteria during observation and another 82 patients who recovered without progression to ALF.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Four patients died; all were in the ALF group. The variables of age, incidence of autoimmune hepatitis, model of end\u2010stage liver disease score, values for total bilirubin and prothrombin time (PT)\u2010international ratio, and Japan Hepatic Encephalopathy Prediction Model (JHEPM) probability at registration were significantly higher in ALF patients than in ALI patients. In multivariate analysis, PT and JHEPM were identified as risk factors for progression to ALF. The cut\u2010off values of 13%, 4.9%, 65%, and 1.32% for the model of end\u2010stage liver disease score, JHEPM probability, PT, and PT\u2010international ratio values, respectively, had high negative predictive values. Furthermore, among patients whose JHEPM was underestimated, none died due to ALF.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The JHEPM probability is a predictive parameter that can be used to decide a follow\u2010up treatment strategy for ALI patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jgh.13819","type":"journal-article","created":{"date-parts":[[2017,5,10]],"date-time":"2017-05-10T02:56:44Z","timestamp":1494385004000},"page":"277-282","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Predictive formula of coma onset and prothrombin time to distinguish patients who recover from acute liver injury"],"prefix":"10.1111","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9627-138X","authenticated-orcid":false,"given":"Keisuke","family":"Kakisaka","sequence":"first","affiliation":[{"name":"Division of Hepatology, Department of Internal Medicine Iwate Medical University  Morioka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuji","family":"Suzuki","sequence":"additional","affiliation":[{"name":"Division of Hepatology, Department of Internal Medicine Iwate Medical University  Morioka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kojiro","family":"Kataoka","sequence":"additional","affiliation":[{"name":"Division of Hepatology, Department of Internal Medicine Iwate Medical University  Morioka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yohei","family":"Okada","sequence":"additional","affiliation":[{"name":"Division of Hepatology, Department of Internal Medicine Iwate Medical University  Morioka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasuhiro","family":"Miyamoto","sequence":"additional","affiliation":[{"name":"Division of Hepatology, Department of Internal Medicine Iwate Medical University  Morioka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hidekatsu","family":"Kuroda","sequence":"additional","affiliation":[{"name":"Division of Hepatology, Department of Internal Medicine Iwate Medical University  Morioka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasuhiro","family":"Takikawa","sequence":"additional","affiliation":[{"name":"Division of Hepatology, Department of Internal Medicine Iwate Medical University  Morioka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,12,28]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00535-012-0624-x"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2003-42644"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1746.2010.06574.x"},{"key":"e_1_2_6_5_1","article-title":"On the brink of death: managing acute liver failure","author":"Maheshwari R","year":"2016","journal-title":"Am. 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