{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T13:36:08Z","timestamp":1790429768186,"version":"4.1.0"},"reference-count":30,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2017,12,28]],"date-time":"2017-12-28T00:00:00Z","timestamp":1514419200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["15K08991"],"award-info":[{"award-number":["15K08991"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["26293175D"],"award-info":[{"award-number":["26293175D"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2018,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Aim<\/jats:title><jats:p>Recent studies have demonstrated that B cells and follicular helper T (Tfh) cells, which are central regulators of humoral immune response, contribute to the development and progression of autoimmune diseases. Because Tfh cells can be divided into several subsets with distinct functional properties, this study aimed to examine the roles of different subsets of circulating Tfh cells in the immune pathogenesis of autoimmune hepatitis (AIH).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Thirty\u2010five patients with AIH, 28 patients with primary biliary cholangitis, 22 patients with chronic hepatitis B (CHB), and 44 health controls (HC) were enrolled. The frequencies of different Tfh subsets in the blood and liver were examined by flow cytometry and immunohistochemical staining. The function of circulating Tfh subsets was examined after <jats:italic>in vitro<\/jats:italic> stimulation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In newly diagnosed AIH patients, the frequency of circulating chemokine C\u2010C receptor 7<jats:sup>\u2212<\/jats:sup>programmed cell death\u20101<jats:sup>+<\/jats:sup> Tfh subset was significantly increased compared with that in CHB patients and HC, significantly correlated with clinical parameters, including serum IgG, prothrombin time and albumin levels, and significantly decreased after corticosteroid treatment. In the liver of AIH patients, the frequencies of activated Tfh subsets were significantly increased and positively correlated with those in the blood. Moreover, the ability to produce interleukin\u201021 and interleukin\u201017 from circulating Tfh cells was significantly increased in AIH patients compared with HC.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>These results significantly extend our understanding of Tfh subsets in AIH and suggest a potential role of dysregulated chemokine C\u2010C receptor 7<jats:sup>\u2212<\/jats:sup>programmed cell death\u20101<jats:sup>+<\/jats:sup> Tfh subset in the pathogenesis and disease progression of AIH.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jgh.13844","type":"journal-article","created":{"date-parts":[[2017,6,7]],"date-time":"2017-06-07T22:36:40Z","timestamp":1496875000000},"page":"298-306","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Possible involvement of chemokine C\u2010C receptor 7<sup>\u2212<\/sup>programmed cell death\u20101<sup>+<\/sup> follicular helper T\u2010cell subset in the pathogenesis of autoimmune hepatitis"],"prefix":"10.1111","volume":"33","author":[{"given":"Naruhiro","family":"Kimura","sequence":"first","affiliation":[{"name":"Division of Gastroenterology and Hepatology Niigata University Graduate School of Medical and Dental Sciences  Niigata Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4791-6107","authenticated-orcid":false,"given":"Satoshi","family":"Yamagiwa","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology Niigata University Graduate School of Medical and Dental Sciences  Niigata Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomoyuki","family":"Sugano","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology Niigata University Graduate School of Medical and Dental Sciences  Niigata 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