{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,9]],"date-time":"2025-09-09T21:01:28Z","timestamp":1757451688995,"version":"3.37.3"},"reference-count":44,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2018,1,26]],"date-time":"2018-01-26T00:00:00Z","timestamp":1516924800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Pharmasset, Inc. Princeton, New Jersey"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2018,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Aim<\/jats:title><jats:p>Liver macrophages are activated in chronic hepatitis B virus (CHB) infection and play a pivotal role in hepatic inflammation and fibrosis. However, their role during antiviral treatment is unclear. The soluble (s) macrophage activation markers, sCD163 and mannose receptor (sMR), are released during liver damage, and their serum levels reflect liver disease severity and portal hypertension. We aimed to investigate associations between sCD163 and sMR and histopathological activity and fibrosis and changes in sCD163, sMR, and hepatic CD163\u2010expression following antiviral treatment in CHB patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We assessed Ishak histological necroinflammatory activity and fibrosis scores in liver biopsies from 254 CHB patients and serially in 71 patients before and after nucleoside\u2010analogue treatment. Liver CD163\u2010expression was semi\u2010quantitatively determined by immunohistochemistry and serum sCD163 and sMR measured by enzyme\u2010linked immunosorbent assays.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Before treatment, the mean levels of sCD163 and sMR were 3.57 (SD 1.72) mg\/L and 0.35 (0.12) mg\/L. sCD163 and sMR increased with histological inflammatory activity (sCD163: <jats:italic>r<\/jats:italic>\u00a0=\u00a00.46, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.00001; sMR: <jats:italic>r<\/jats:italic>\u00a0=\u00a00.48, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.00001) and correlated positively with fibrosis (sCD163: OR 1.16, 95% CI:1.03\u20131.31; sMR: OR 1.34, 95% CI:1.13\u20131.59); both were markers of fibrosis independent of other biochemical parameters and risk factors. Antiviral treatment significantly reduced sCD163 (3.76 [1.46] <jats:italic>vs<\/jats:italic> 2.31 [0.95], <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.00001), sMR (0.37 [0.1] <jats:italic>vs<\/jats:italic> 0.29 [0.07], <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.00001) and hepatic CD163\u2010expression (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.0002).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The macrophage activation markers sCD163 and sMR were associated with activity and fibrosis in liver biopsies from CHB patients. Both serum markers decreased with antiviral treatment, along with decreased hepatic CD163 expression.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jgh.13849","type":"journal-article","created":{"date-parts":[[2017,6,15]],"date-time":"2017-06-15T22:15:39Z","timestamp":1497564939000},"page":"484-491","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Soluble CD163 and mannose receptor associate with chronic hepatitis B activity and fibrosis and decline with treatment"],"prefix":"10.1111","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2494-0526","authenticated-orcid":false,"given":"Tea Lund","family":"Laursen","sequence":"first","affiliation":[{"name":"Department of Hepatology and Gastroenterology Aarhus University Hospital  Aarhus Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Grace Lai\u2010Hung","family":"Wong","sequence":"additional","affiliation":[{"name":"Department of Medicine and Therapeutics and Institute of Digestive Disease The Chinese University of Hong Kong  Hong Kong"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Konstantin","family":"Kazankov","sequence":"additional","affiliation":[{"name":"Department of Hepatology and Gastroenterology Aarhus University Hospital  Aarhus Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Sandahl","sequence":"additional","affiliation":[{"name":"Department of Hepatology and Gastroenterology Aarhus University Hospital  Aarhus Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Holger Jon","family":"M\u00f8ller","sequence":"additional","affiliation":[{"name":"Department of Clinical Biochemistry Aarhus University Hospital  Aarhus Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephen","family":"Hamilton\u2010Dutoit","sequence":"additional","affiliation":[{"name":"Institute of Pathology Aarhus University Hospital  Aarhus Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jacob","family":"George","sequence":"additional","affiliation":[{"name":"Storr Liver Centre, Westmead Institute for Medical Research Westmead Hospital and University of Sydney  Westmead New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Henry Lik\u2010Yuen","family":"Chan","sequence":"additional","affiliation":[{"name":"Department of Medicine and Therapeutics and Institute of Digestive Disease The Chinese University of Hong Kong  Hong Kong"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Henning","family":"Gr\u00f8nb\u00e6k","sequence":"additional","affiliation":[{"name":"Department of Hepatology and Gastroenterology Aarhus University Hospital  Aarhus 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