{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T17:40:23Z","timestamp":1770745223625,"version":"3.49.0"},"reference-count":31,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2018,1,26]],"date-time":"2018-01-26T00:00:00Z","timestamp":1516924800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2018,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Aims<\/jats:title><jats:p>Many patients with intestinal Beh\u00e7et's disease (BD) still suffer from gastrointestinal symptoms despite the disease being in endoscopic or radiological remission. Previous studies report that small intestinal bacterial overgrowth (SIBO) can be associated with inflammatory bowel disease. However, there have been no reports about SIBO in patients with intestinal BD. We sought to identify the frequency of SIBO in patients with inactive intestinal BD by hydrogen breath test (HBT) and to investigate the efficacy of rifaximin as a treatment for SIBO.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Twenty\u2010five patients with intestinal BD who had gastrointestinal symptoms even in endoscopic or radiological remission status were enrolled between January 2012 and January 2016. The patients filled out a questionnaire regarding their subjective gastrointestinal symptoms and took an HBT. Patients with positive HBT results were recommended to take 800\u2010mg rifaximin daily for 14\u00a0days.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Nine patients (9\/25, 36%) had a positive HBT test. Eight (8\/9, 88.9%) were women, and their mean age was 48.7\u00a0years. The most common symptom was abdominal distension (8\/9, 88.9%), followed by abdominal discomfort (6\/9, 66.7%). Rifaximin was prescribed to the nine patients with positive HBT, but two patients refused to take the medication. Four weeks later, six of the seven patients taking rifaximin (85.7%) reported symptom improvement, and none of them reported adverse events.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>More than one\u2010third of the patients with inactive intestinal BD who had gastrointestinal symptoms were accompanied by SIBO using HBT. Rifaximin might be an effective and safe drug to treat these patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jgh.13855","type":"journal-article","created":{"date-parts":[[2017,6,30]],"date-time":"2017-06-30T22:22:44Z","timestamp":1498861364000},"page":"375-379","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Rediscover the clinical value of small intestinal bacterial overgrowth in patients with intestinal Beh\u00e7et's disease"],"prefix":"10.1111","volume":"33","author":[{"given":"Jung Hyun","family":"Jo","sequence":"first","affiliation":[{"name":"Department of Internal Medicine and Institute of Gastroenterology Yonsei University College of Medicine  Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Soo Jung","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Institute of Gastroenterology Yonsei University College of Medicine  Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jae Hee","family":"Cheon","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Institute of Gastroenterology Yonsei University College of Medicine  Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tae Il","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Institute of Gastroenterology Yonsei University College of Medicine  Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Won Ho","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Institute of Gastroenterology Yonsei University College of Medicine  Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,1,26]]},"reference":[{"key":"e_1_2_7_2_1","first-page":"1078","article-title":"Criteria for diagnosis of Behcet's disease. International Study Group for Behcet's Disease","volume":"335","year":"1990","journal-title":"Lancet"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00535-007-2090-4"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.3349\/ymj.1997.38.6.428"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1177\/0884533613485882"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/MEG.0000000000000122"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v13.45.6016"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2005.40795.x"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2006.108712"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-013-2694-x"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2036.2003.01800.x"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.3109\/00365521.2015.1050691"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01297077"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v20.i38.13999"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2982.2011.01686.x"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.5009\/gnl16132"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/MCG.0b013e3181ef3476"},{"key":"e_1_2_7_18_1","doi-asserted-by":"crossref","DOI":"10.1007\/s10620-010-1356-5","article-title":"Small intestinal bacterial overgrowth in patients with morbid obesity","volume":"56","author":"Jouet P","year":"2011","journal-title":"Dig. Dis. Sci."},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-010-1447-3"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1097\/MCG.0b013e3181557e67"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1177\/1756283X11422264"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/jgh.13530"},{"key":"e_1_2_7_23_1","doi-asserted-by":"crossref","DOI":"10.1155\/2016\/5423043","article-title":"The role of fecal calprotectin in evaluating intestinal involvement of Behcet's disease","volume":"2016","author":"Ozseker B","year":"2016","journal-title":"Dis. Markers"},{"key":"e_1_2_7_24_1","first-page":"111","article-title":"Antibiotic therapy in small intestinal bacterial overgrowth: rifaximin versus metronidazole","volume":"13","author":"Lauritano EC","year":"2009","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(99)70336-7"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2005.02516.x"},{"key":"e_1_2_7_27_1","first-page":"143","article-title":"Small intestinal bacterial overgrowth produces symptoms in irritable bowel syndrome which are improved by rifaximin. A pilot study","volume":"51","author":"Moraru IG","year":"2013","journal-title":"Rom. J. Intern. Med."},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1097\/MAJ.0b013e3180536784"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2007.03259.x"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1517\/13543780902780175"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2013.09.055"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2009.205476"}],"container-title":["Journal of Gastroenterology and Hepatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjgh.13855","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jgh.13855","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,27]],"date-time":"2023-09-27T14:37:18Z","timestamp":1695825438000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jgh.13855"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,1,26]]},"references-count":31,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2018,2]]}},"alternative-id":["10.1111\/jgh.13855"],"URL":"https:\/\/doi.org\/10.1111\/jgh.13855","archive":["Portico"],"relation":{},"ISSN":["0815-9319","1440-1746"],"issn-type":[{"value":"0815-9319","type":"print"},{"value":"1440-1746","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,1,26]]},"assertion":[{"value":"2017-06-20","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2017-06-25","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-01-26","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}