{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T17:01:34Z","timestamp":1789750894297,"version":"4.0.1"},"reference-count":23,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2018,1,26]],"date-time":"2018-01-26T00:00:00Z","timestamp":1516924800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["NRF\u20102017R1A2B4004988"],"award-info":[{"award-number":["NRF\u20102017R1A2B4004988"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2018,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Aim<\/jats:title><jats:p>A family history of colorectal cancer (CRC) is an important risk factor for CRC, but more detailed data are needed to prepare effective screening guidelines. We aimed to evaluate the risk of colorectal neoplasia (CRN) among individuals with different relatives affected by CRC (the first\u2010degree relatives [FDRs] or the second\u2010degree relatives or the first cousins) and to assess the effects of family histories according to age groups (30\u201339, 40\u201349, and \u2265\u00a050\u00a0years).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A cross\u2010sectional study was performed on 98\u00a0562 asymptomatic examinees aged \u2265\u00a030\u00a0years who underwent colonoscopy as part of a health checkup.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Mean age of the study population was 41.4\u00a0years, and the prevalence of CRN was 15.7%. Participants with \u2265\u00a01 FDRs and \u2265\u00a02 FDRs affected by CRC had a higher risk of CRN than those with no family history of CRC, while those with \u2265\u00a01 second\u2010degree relatives or first cousins affected did not. In the 30\u201339 and 40\u201349\u00a0years age groups, a family history of CRC in parents was a risk factor for CRN and advanced CRN, but not in siblings. By contrast, in the \u2265\u00a050 age group, participants with affected siblings (reference group) had a significantly higher risk for advanced CRN than those with affected parents (adjusted odds ratio; 95% confidence interval: 0.39; 0.16\u20130.94 in father and 0.43; 0.18\u20130.995 in mother).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The risk of CRN can be different according to the types of family members affected, and the impact of such family histories can be different according to age.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jgh.13905","type":"journal-article","created":{"date-parts":[[2017,7,24]],"date-time":"2017-07-24T08:12:47Z","timestamp":1500883967000},"page":"397-403","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["The risk of colorectal neoplasia can be different according to the types of family members affected by colorectal cancer"],"prefix":"10.1111","volume":"33","author":[{"given":"Nam Hee","family":"Kim","sequence":"first","affiliation":[{"name":"Preventive Healthcare Center School of Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyo\u2010Joon","family":"Yang","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Department of Internal Medicine School of Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soo\u2010Kyung","family":"Park","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Department of Internal Medicine School of Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jung Ho","family":"Park","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Department of Internal Medicine School of Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong Il","family":"Park","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Department of Internal Medicine School of Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chong Il","family":"Sohn","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Department of Internal Medicine School of Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoon Suk","family":"Jung","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Department of Internal Medicine School of Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,1,26]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.5217\/ir.2014.12.4.268"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.29210"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/bmb\/lds040"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2009.104"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0028-1119626"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2007.146316"},{"key":"e_1_2_6_8_1","first-page":"105","article-title":"Epidemiology of colorectal cancer","volume":"7","author":"Marley AR","year":"2016","journal-title":"Int. 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