{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T00:05:46Z","timestamp":1790726746447,"version":"4.1.0"},"reference-count":32,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2018,1,26]],"date-time":"2018-01-26T00:00:00Z","timestamp":1516924800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Gastroenterology Association of Thailand"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2018,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Aim<\/jats:title><jats:p>Current treatments of functional dyspepsia (FD) are unsatisfied. Tricyclic antidepressants alter visceral hypersensitivity and brain\u2013gut interaction. We assessed the efficacy and safety of nortriptyline in patients with FD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients diagnosed with FD according to Rome III criteria who failed to respond to proton pump inhibitor and prokinetic treatment were randomly assigned to either once daily 10\u2010mg nortriptyline or placebo. The primary endpoint was the rate of responders defined as &gt;\u00a050% reduction in dyspepsia symptom score after 8\u00a0weeks of treatment. The secondary endpoints were improvement in quality of life as assessed by 36\u2010Item Short Form Health Survey score and safety.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Sixty\u2010one patients (nortriptyline 28 and placebo 33) were enrolled. Dyspepsia symptom score and duration of symptoms were balanced at entry between both groups. Eight and seven patients in nortriptyline and placebo groups were lost to follow up. Seven patients withdrew due to mild adverse events (nortriptyline 1 and placebo 6). Overall, 19 with nortriptyline and 20 with placebo completed the study. Patients receiving nortriptyline did not achieve higher response rate than those in placebo in both intention\u2010to\u2010treat (53.6% <jats:italic>vs<\/jats:italic> 57.6%, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.75) and per\u2010protocol (76.5% <jats:italic>vs<\/jats:italic> 73.7%, <jats:italic>P<\/jats:italic>\u00a0=\u00a01.00) analyses. Nortriptyline did not provide improvement in quality of life. The mean difference was 3.8 (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.36) and 0.88 (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.86) by intention\u2010to\u2010treat and 2.9 (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.57) and 3.5 (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.57) by per\u2010protocol analyses in physical and mental component, respectively. All adverse events were minor and similar in both groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Nortriptyline was not superior to placebo in management of patients with FD.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jgh.13914","type":"journal-article","created":{"date-parts":[[2017,8,2]],"date-time":"2017-08-02T21:46:37Z","timestamp":1501710397000},"page":"411-417","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Efficacy and safety of nortriptyline in functional dyspepsia in Asians: A randomized double\u2010blind placebo\u2010controlled trial"],"prefix":"10.1111","volume":"33","author":[{"given":"Uayporn","family":"Kaosombatwattana","sequence":"first","affiliation":[{"name":"Division of Gastroenterology, Department of Medicine, Faculty of Medicine, Siriraj Hospital Mahidol University  Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Supot","family":"Pongprasobchai","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Department of Medicine, Faculty of Medicine, Siriraj Hospital Mahidol University  Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julajak","family":"Limsrivilai","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Department of Medicine, Faculty of Medicine, Siriraj Hospital Mahidol University  Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monthira","family":"Maneerattanaporn","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Department of Medicine, Faculty of Medicine, Siriraj Hospital Mahidol University  Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Somchai","family":"Leelakusolvong","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Department of Medicine, Faculty of Medicine, Siriraj Hospital Mahidol University  Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tawesak","family":"Tanwandee","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Department of Medicine, Faculty of Medicine, Siriraj Hospital Mahidol University  Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,1,26]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.5056\/jnm.2011.17.3.235"},{"key":"e_1_2_6_3_1","first-page":"307","article-title":"Guidelines\u2014Rome III diagnostic criteria for functional gastrointestinal disorders","volume":"15","author":"Rome F","year":"2006","journal-title":"J Gastrointestin. Liver Dis"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2014.231"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2005.11.059"},{"key":"e_1_2_6_6_1","first-page":"e1","article-title":"Clinical practice guideline on the management of patients with dyspepsia. Update 2012","volume":"44","author":"Gisbert JP","year":"2012","journal-title":"Aten. Primaria"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2005.00225.x"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1746.2011.07037.x"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00535-014-1022-3"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(03)00808-4"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2982.2006.00779.x"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2005.30375.x"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2982.2007.01029.x"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-006-9378-8"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1159\/000088363"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjp.0707253"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9343(99)00299-5"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2015.413"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2005.02473.x"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2011.04775.x"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.v60n1204"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1746.2011.06806.x"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2006.03233.x"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11739-010-0467-5"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2036.1998.00404.x"},{"key":"e_1_2_6_26_1","first-page":"S130","article-title":"Reliability of Thai version of SF\u201036 questionnaire for the evaluation of quality of life in cardiac patients","volume":"83","author":"Krittayaphong R","year":"2000","journal-title":"J. Med. Assoc. Thail."},{"key":"e_1_2_6_27_1","first-page":"99","article-title":"Quality of life assessment in Thai patients with allergic rhinoconjunctivitis using the SF\u201036 questionnaire (Thai version)","volume":"43","author":"Bunnag C","year":"2005","journal-title":"Rhinology"},{"key":"e_1_2_6_28_1","first-page":"S84","article-title":"Reliability of the Thai version of SF\u201036 questionnaire for an evaluation of quality of life in multiple sclerosis patients in multiple sclerosis clinic at Siriraj Hospital","volume":"94","author":"Laosanguanek N","year":"2011","journal-title":"J. Med. Assoc. Thail."},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2008.02021.x"},{"key":"e_1_2_6_30_1","doi-asserted-by":"crossref","first-page":"4214","DOI":"10.3748\/wjg.v19.i26.4214","article-title":"Effect of amitriptyline on gastrointestinal function and brain\u2010gut peptides: a double\u2010blind trial","volume":"19","author":"Huang W","year":"2013","journal-title":"World J. Gastroenterol."},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.1998.00160.x"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2015.04.020"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2015-310721"}],"container-title":["Journal of Gastroenterology and Hepatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjgh.13914","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jgh.13914","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,27]],"date-time":"2023-09-27T14:38:05Z","timestamp":1695825485000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jgh.13914"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,1,26]]},"references-count":32,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2018,2]]}},"alternative-id":["10.1111\/jgh.13914"],"URL":"https:\/\/doi.org\/10.1111\/jgh.13914","archive":["Portico"],"relation":{},"ISSN":["0815-9319","1440-1746"],"issn-type":[{"value":"0815-9319","type":"print"},{"value":"1440-1746","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,1,26]]},"assertion":[{"value":"2016-10-05","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2017-07-28","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-01-26","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}