{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T04:08:16Z","timestamp":1789704496158,"version":"4.0.1"},"reference-count":39,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2018,2,22]],"date-time":"2018-02-22T00:00:00Z","timestamp":1519257600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2018,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Aim<\/jats:title><jats:p>Gastroesophageal reflux disease (GERD) and functional dyspepsia (FD) often coexist or overlap. In this study, the efficacy of acotiamide in combination with a standard dose of rabeprazole for GERD and FD was compared with that of a double dose of rabeprazole.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients with overlap between GERD and FD experiencing heartburn and epigastric fullness symptoms after standard\u2010dose proton pump inhibitor (PPI) for \u2265\u00a08\u00a0weeks were randomized into two groups and received either acotiamide 300\u00a0mg\/day + rabeprazole 10\u00a0mg\/day or rabeprazole 20\u00a0mg\/day for 4\u00a0weeks. Efficacy was assessed by reductions in symptom scores using the Izumo scale questionnaire and modified F\u2010scale questionnaire.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>As the primary endpoint, three upper gastrointestinal symptoms (heartburn, epigastralgia, and epigastric fullness) were reduced by \u2265\u00a050% in 40.8% and 46.9% of patients in the combination and PPI double\u2010dose groups, respectively, with no significant difference between the two groups. Essentially similar results were obtained for the modified F\u2010scale questionnaire. No serious adverse events were noted.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Acotiamide 300\u00a0mg\/day in combination with rabeprazole 10\u00a0mg\/day or rabeprazole 20\u00a0mg\/day relieved symptoms in patients with overlap between GERD and FD experiencing heartburn and epigastric fullness symptoms after standard\u2010dose PPI for \u2265\u00a08\u00a0weeks, and the efficacies did not differ between the two treatments. The combination therapy may be an alternative option for persistent symptoms in these patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jgh.13970","type":"journal-article","created":{"date-parts":[[2017,9,2]],"date-time":"2017-09-02T03:36:35Z","timestamp":1504323395000},"page":"623-630","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Therapy of gastroesophageal reflux disease and functional dyspepsia overlaps with symptoms after usual\u2010dose proton pump inhibitor: Acotiamide plus usual\u2010dose proton pump inhibitor <i>versus<\/i> double\u2010dose proton pump inhibitor"],"prefix":"10.1111","volume":"33","author":[{"given":"Toshihisa","family":"Takeuchi","sequence":"first","affiliation":[{"name":"Second Department of Internal Medicine Osaka Medical College  Osaka 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