{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,9,3]],"date-time":"2024-09-03T05:53:09Z","timestamp":1725342789686},"reference-count":26,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2018,1,26]],"date-time":"2018-01-26T00:00:00Z","timestamp":1516924800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2018,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Aim<\/jats:title><jats:p>It has been speculated that impaired salivary flow contributes to abnormal acid clearance in patients with erosive esophagitis (EE). For easy and objective assessment of salivary function, we developed a salivary gland blood flow measurement technique using continuous\u2010wave Doppler sonography. In the present study, we evaluated the salivary secretory function in patients with EE and those with nonerosive reflux disease (NERD) using this method.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Doppler waveform analysis was performed on the facial artery to assess blood inflow to the submandibular gland of 30 healthy subjects (HS). Blood flow was compared before and after secretory stimulation with 1\u00a0mL of lemon juice. Saliva was simultaneously collected and weighed before and after stimulation. Continuous\u2010wave Doppler sonography was also performed in patients with EE and NERD. The size of the submandibular gland was compared in 26 patients with EE, 41 patients with NERD, and 86 HS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The submandibular gland blood flow increased after stimulation in all HS. Both within\u2010day and day\u2010to\u2010day reproducibility were good. There was a significant correlation between the percent increase in the maximum velocity and the percent increase in salivary secretion. Although the size of the submandibular gland was not significantly different among the three groups, the percent increase in the maximum velocity in patients with EE was significantly smaller than that in HS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>We have established an easy method of assessing salivary function in daily practice. This study revealed that a decrease in salivary secretory function is involved in the pathology of EE.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jgh.14002","type":"journal-article","created":{"date-parts":[[2017,9,28]],"date-time":"2017-09-28T15:39:11Z","timestamp":1506613151000},"page":"807-813","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Differences in salivary secretory function between patients with erosive esophagitis and those with nonerosive reflux disease"],"prefix":"10.1111","volume":"33","author":[{"given":"Noriaki","family":"Manabe","sequence":"first","affiliation":[{"name":"Division of Endoscopy and Ultrasonography, Department of Laboratory Medicine Kawasaki Medical School  Kurashiki Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ken","family":"Haruma","sequence":"additional","affiliation":[{"name":"Department of General Internal Medicine 2 Kawasaki Medical School General Medical Center  Okayama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroaki","family":"Kusunoki","sequence":"additional","affiliation":[{"name":"Department of Health Care Medicine Kawasaki Medical School  Kurashiki Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomoari","family":"Kamada","sequence":"additional","affiliation":[{"name":"Department of Health Care Medicine Kawasaki Medical School General Medical Center  Okayama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiro","family":"Hata","sequence":"additional","affiliation":[{"name":"Division of Endoscopy and Ultrasonography, Department of Laboratory Medicine Kawasaki Medical School  Kurashiki Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,1,26]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198212163072503"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(81)80072-8"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000441-200311000-00003"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(87)90270-8"},{"key":"e_1_2_6_6_1","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/S0016-5085(82)80286-2","article-title":"Acid neutralizating capacity of human saliva","volume":"83","author":"Helm JF","year":"1982","journal-title":"Gastroenterology"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(97)70025-8"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1159\/000151249"},{"key":"e_1_2_6_9_1","first-page":"R747","article-title":"Parasympathetic\u2010mediated reflex salivation and vasodilatation in the cat submandibular gland","volume":"267","author":"Izumi H","year":"1994","journal-title":"Am. 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