{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T16:01:28Z","timestamp":1791388888652,"version":"4.3.3"},"reference-count":45,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2018,2,14]],"date-time":"2018-02-14T00:00:00Z","timestamp":1518566400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100012166","name":"national basic research program of China (973 program)","doi-asserted-by":"crossref","award":["2009CB522403"],"award-info":[{"award-number":["2009CB522403"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Zhejiang provincial science and technology plan","award":["2011C23101"],"award-info":[{"award-number":["2011C23101"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2018,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Aim<\/jats:title><jats:p>Cholangitis, bacteremia, and pyogenic liver abscess (PLA) can be often caused by intrahepatic bile ducts stone (IBDS), which is endemic to South\u2010East Asia. The association between IBDS and cholangiocarcinoma has been well recognized. Concomitant cholangiocarcinoma in the PLA related to IBDS is often missed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A case\u2013control study consisting of 64 patients with PLA related to IBDS and 256 control patients with PLA not related to IBDS was used to investigate clinical features of PLA and incidence of concomitant cholangiocarcinoma in patients with PLA related to IBDS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The main imaging manifestations of PLA related to IBDS was cystic\u2010solid lesions and solid lesions. Of seven patients (10.9%) with pathology\u2010proven cholangiocarcinoma in the same area of PLA related to IBDS among 64 patients, only two patients were initially diagnosed as having concomitant cholangiocarcinoma by biopsy, and other five patients diagnosed as acute inflammatory lesion. Within 60\u00a0days after onset, the infection\u2010related death rate and recurrence rate in patients with PLA related to IBDS were 12.9% and 20.3%, respectively, whereas in patients with PLA not related to IBDS were 3.9% and 3.1%, respectively. Only 25% of patients with PLA related to IBDS underwent surgery after admission. The main pathogens in PLA patients related to IBDS were <jats:styled-content style=\"fixed-case\"><jats:italic>Escherichia coli<\/jats:italic><\/jats:styled-content> and extended\u2010spectrum beta\u2010lactamase\u2010producing <jats:italic>Enterobacteriaceae<\/jats:italic>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The imaging manifestations of PLA related to IBDS often present cystic\u2010solid or solid lesions. PLA related to IBDS is characterized by high rate of recurrence and infection\u2010related death, difficulty in diagnosis of concomitant cholangicarcinoma.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jgh.14010","type":"journal-article","created":{"date-parts":[[2017,10,6]],"date-time":"2017-10-06T10:06:39Z","timestamp":1507284399000},"page":"1092-1099","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Pyogenic liver abscess related to intrahepatic bile duct stones: Difficulties in infectious control and diagnosis of concomitant cholangiocarcinoma"],"prefix":"10.1111","volume":"33","author":[{"given":"Shao\u2010hua","family":"Shi","sequence":"first","affiliation":[{"name":"Division of Hepatobiliary and Pancreatic Surgery, First Affiliated Hospital, School of Medicine Zhejiang University  Hangzhou Zhejiang Province 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