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Thrombocytopenia recovers after viral eradication. The current study explored the rate and factors associated with platelet (PLT) recovery, which may represent the degree of liver fibrosis regression.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 466 patients who achieved a sustained virological response were enrolled to compare the PLT change after a mean follow\u2010up period of 85.5\u00a0months (range 12\u2013163\u00a0months).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Platelet counts increased significantly after achieving sustained virological response (from 166\u00a0\u00b1\u00a055\u00a0\u00d7\u00a010<jats:sup>3<\/jats:sup> to 201\u00a0\u00b1\u00a061\u00a0\u00d7\u00a010<jats:sup>3<\/jats:sup>\u00a0<jats:italic>u<\/jats:italic>\/L, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001). The median PLT count increment was 5.03\u00a0\u00d7\u00a010<jats:sup>3<\/jats:sup>\u00a0<jats:italic>u<\/jats:italic>\/L per year. Logistic regression analysis revealed that factors associated with slow PLT count recovery were high pretreatment PLT counts (odds ratio [OR]\/ 95% confidence intervals [CI]: 0.992\/0.989\u20130.996, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001) and hepatitis B virus (HBV) co\u2010infection (OR\/CI: 0.416\/0.220\u20130.785, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.007). High PLT counts were the only factor associated with slow PLT recovery in patients with mild liver disease (F0\u20132) (OR\/CI: 0.992\/0.987\u20130.996, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001). On the other hand, HBV co\u2010infection was the only factor associated with slow PLT recovery in patients with advanced fibrosis (OR\/CI: 0.207\/0.054\u20130.789, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.02). Linear regression analysis of factors correlated to the delta PLT count change per year in patients with F0\u20132 included pretreatment white blood cell (\u03b2: \u22120.001; CI: \u22120.002\u20130.000; <jats:italic>P<\/jats:italic>\u00a0=\u00a00.01) and pretreatment PLT counts (\u03b2: \u22120.037; CI: \u22120.061 to \u22120.013; <jats:italic>P<\/jats:italic>\u00a0=\u00a00.003). HBsAg seropositivity was the only factor correlated to the delta PLT count change per year (\u03b2: \u221210.193; CI: \u221216.752\u20133.635; <jats:italic>P<\/jats:italic>\u00a0=\u00a00.003) among patients with F3\u20134.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Platelet counts recovered after hepatitis C virus eradication. HBV dual infection disrupted PLT count recovery, especially in CHC patients with advanced liver disease.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jgh.14017","type":"journal-article","created":{"date-parts":[[2017,10,11]],"date-time":"2017-10-11T10:32:46Z","timestamp":1507717966000},"page":"1108-1114","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Interference of hepatitis B virus dual infection in platelet count recovery in chronic hepatitis C patients with curative antiviral therapy"],"prefix":"10.1111","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3367-068X","authenticated-orcid":false,"given":"Chung\u2010Feng","family":"Huang","sequence":"first","affiliation":[{"name":"Hepatobiliary Division, Department of Internal Medicine, Kaohsiung Medical University Hospital Kaohsiung Medical University  Kaohsiung Taiwan"},{"name":"Faculty of Internal Medicine, School of Medicine, College of Medicine 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Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zu\u2010Yau","family":"Lin","sequence":"additional","affiliation":[{"name":"Hepatobiliary Division, Department of Internal Medicine, Kaohsiung Medical University Hospital Kaohsiung Medical University  Kaohsiung Taiwan"},{"name":"Faculty of Internal Medicine, School of Medicine, College of Medicine Kaohsiung Medical University  Kaohsiung Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shinn\u2010Cherng","family":"Chen","sequence":"additional","affiliation":[{"name":"Hepatobiliary Division, Department of Internal Medicine, Kaohsiung Medical University Hospital Kaohsiung Medical University  Kaohsiung Taiwan"},{"name":"Faculty of Internal Medicine, School of Medicine, College of Medicine Kaohsiung Medical University  Kaohsiung Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chia\u2010Yen","family":"Dai","sequence":"additional","affiliation":[{"name":"Hepatobiliary 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