{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T09:19:57Z","timestamp":1762507197671,"version":"3.37.3"},"reference-count":25,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2018,2,6]],"date-time":"2018-02-06T00:00:00Z","timestamp":1517875200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2018,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Aim<\/jats:title><jats:p>Although mortality rates of colorectal cancer (CRC) have been increasing in Japan, its screening rates remain stagnant at 19.2% among Japanese population aged &gt;\u00a040\u00a0years in 2014. To evaluate the importance of CRC screening by fecal occult blood test (FOBT), this study estimated the incidence of FOBT\u2010positivity and CRC by sex\u2013age stratification and clarified the risk factors for CRC.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Between 2007 and 2014, 56\u00a0324 residents (21\u00a0517 men and 34\u00a0807 women) were enrolled in this study. The sex\u2013age\u2010stratified incidence rates of FOBT\u2010positivity and CRC were estimated by records from health checkups and colonoscopy. Regarding CRC incidence rate in particular, positive predictive value was adopted to adjust bias of FOBT\u2010positivity that did not undergo colonoscopy by person\u2010year method. To investigate the risks of CRC onset, a nested case\u2013control study with 1:10 person\u2010matching on sex and age was performed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Incidence rates of FOBT\u2010positivity and CRC are 4183\/100\u00a0000 person\u2010year (100\u00a0Kpy) and 141.3\/100\u00a0Kpy, respectively. In both cases, men has higher incidence rate than women (1.3 times for FOBT; 4977 <jats:italic>vs<\/jats:italic> 3718\/100\u00a0Kpy and 2.3 times for CRC; 217.0 <jats:italic>vs<\/jats:italic> 96.4\/100\u00a0Kpy).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The records from health checkups were useful to estimate incidence rates of CRC with this procedure. The age\u2010stratified incidence rate indicated the importance of CRC screening by FOBT, especially for men and those aged &gt;\u00a050\u00a0years. Additionally, it is strongly recommended to do further investigation if positive for initial FOBT screening especially for those who are &gt;\u00a070\u00a0years.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jgh.14020","type":"journal-article","created":{"date-parts":[[2017,10,19]],"date-time":"2017-10-19T07:22:40Z","timestamp":1508397760000},"page":"855-862","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Incidence and risk factors of colorectal cancer based on 56\u00a0324 health checkups: A 7\u2010year retrospective cohort study"],"prefix":"10.1111","volume":"33","author":[{"given":"Toshiko","family":"Fujii","sequence":"first","affiliation":[{"name":"Department of Epidemiology, Infectious Disease Control and Prevention, Graduate School of Biomedical and Health Sciences Hiroshima University  Hiroshima Japan"},{"name":"General Affairs Foundation for Community Health and Medicine Promotion in Hiroshima Prefecture  Hiroshima Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masayuki","family":"Ohisa","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Infectious Disease Control and Prevention, Graduate School of Biomedical and Health Sciences Hiroshima University  Hiroshima Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toru","family":"Sako","sequence":"additional","affiliation":[{"name":"General Affairs Foundation for Community Health and Medicine Promotion in Hiroshima Prefecture  Hiroshima Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takayuki","family":"Harakawa","sequence":"additional","affiliation":[{"name":"General Affairs Foundation for Community Health and Medicine Promotion in Hiroshima Prefecture  Hiroshima Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuaki","family":"Sakamune","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Infectious Disease Control and Prevention, Graduate School of Biomedical and Health Sciences Hiroshima University  Hiroshima Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shintaro","family":"Nagashima","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Infectious Disease Control and Prevention, Graduate School of Biomedical and Health Sciences Hiroshima University  Hiroshima Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aya","family":"Sugiyama","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Infectious Disease Control and Prevention, Graduate School of Biomedical and Health Sciences Hiroshima University  Hiroshima Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuichiro","family":"Matsuura","sequence":"additional","affiliation":[{"name":"General Affairs Foundation for Community Health and Medicine Promotion in Hiroshima Prefecture  Hiroshima Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5669-4051","authenticated-orcid":false,"given":"Junko","family":"Tanaka","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Infectious Disease Control and Prevention, Graduate School of Biomedical and Health Sciences Hiroshima University  Hiroshima Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,2,6]]},"reference":[{"key":"e_1_2_6_2_1","unstructured":"Statistics and Information department MSs Ministry of Health Labour and Welfare.Vital statistics of Japan 2014. Statistics and information department Minister's secretariat Ministry of Health Labour and Welfare Health Labour and Welfare Statistics Association2014."},{"key":"e_1_2_6_3_1","unstructured":"Ministry of Health Law.Basic Plan to Promote Cancer Control Programe. Ministry of Health Labour and Welfare2012."},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjgast-2015-000034"},{"key":"e_1_2_6_5_1","unstructured":"The Ministry of Health Law.Roport on regional public health services and health promotion services. 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