{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T10:51:39Z","timestamp":1761562299208},"reference-count":44,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2018,2,14]],"date-time":"2018-02-14T00:00:00Z","timestamp":1518566400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2018,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Aim<\/jats:title><jats:p>Little is known about the risk factors associated with serrated polyps, because the early studies, which occurred before the new World Health Organization classification was introduced, included mixtures of serrated polyps. This study aimed to evaluate the risk factors associated with the presence of sessile serrated adenomas (SSAs) and traditional serrated adenomas (TSAs) using big data analytics.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Using a case\u2013control design, we evaluated the risk factors associated with the presence of SSAs and TSAs. Subjects who underwent colonoscopies from 2002 to 2012 as part of the comprehensive health screening programs undertaken at the Samsung Medical Center, Korea, participated in this study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of the 48\u00a0677 individuals who underwent colonoscopies, 183 (0.4%) had SSAs and 212 (0.4%) had TSAs. The multivariate analysis determined that being aged \u2265\u00a050\u00a0years (odds ratio [OR] 1.91, 95% confidential interval [CI] 1.27\u20132.90, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.002) and a history of colorectal cancer among first\u2010degree relatives (OR 3.14, 95% CI 1.57\u20136.27, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.001) were significant risk factors associated with the presence of SSAs and that being aged \u2265\u00a050\u00a0years (OR 2.61, 95% CI 1.79\u20133.80, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001), obesity (OR 1.63, 95% CI 1.12\u20132.36, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.010), and a higher triglyceride level (OR 1.63, 95% CI 1.12\u20132.36, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.010) were independent risk factors associated with the presence of TSAs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>We used big data analytics to determine the risk factors associated with the presence of specific polyp subgroups, and individuals who have these risk factors should be carefully scrutinized for the presence of SSAs or TSAs during screening colonoscopies.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jgh.14035","type":"journal-article","created":{"date-parts":[[2017,10,31]],"date-time":"2017-10-31T15:41:57Z","timestamp":1509464517000},"page":"1039-1046","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Identification of risk factors for sessile and traditional serrated adenomas of the colon by using big data analysis"],"prefix":"10.1111","volume":"33","author":[{"given":"Jeung Hui","family":"Pyo","sequence":"first","affiliation":[{"name":"Center for Health Promotion Samsung Medical Center  Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sang Yun","family":"Ha","sequence":"additional","affiliation":[{"name":"Department of Pathology, Samsung Medical Center Sungkyunkwan University School of 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