{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T10:14:30Z","timestamp":1791454470683,"version":"4.3.3"},"reference-count":24,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2018,2,21]],"date-time":"2018-02-21T00:00:00Z","timestamp":1519171200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2018,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Aim<\/jats:title><jats:p>Recent evidence indicates that new approach of the diet with low fermentable oligo\u2010di\u2010mono\u2010saccharides and polyols (FODMAPs) may have an effective role in management of the patients with irritable bowel syndrome (IBS). We compared the results of low FODMAP diet with current dietary treatment, general dietary advices (GDA), on the clinical response in patients with diarrhea subtype of IBS (IBS\u2010D).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In this randomized, controlled, single\u2010blind trial, we included 110 patients with IBS\u2010D in two intervention groups. Participants were randomly assigned to the low FODMAP diet (<jats:italic>n<\/jats:italic>\u00a0=\u00a055) and GDA (<jats:italic>n<\/jats:italic>\u00a0=\u00a055) for 6\u00a0weeks after a 10\u2010day screening period. Gastrointestinal symptoms and bowel habit status were evaluated using a symptom severity scoring system and Bristol stool form scale pre\u2010intervention and post\u2010intervention. Patients completed 3\u2010day food diary before and after the intervention.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of 110 patients, 101 completed the dietary interventions. At the baseline, the nutrient intake, severity of symptoms, and demographic data were similar between two groups. After 6\u00a0weeks, the low FODMAP diet improves significantly overall gastrointestinal symptoms scores, stool frequency, and consistency <jats:italic>versus<\/jats:italic> GDA group (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001, and <jats:italic>P<\/jats:italic>\u00a0=\u00a00.003, respectively). Compared with the baseline, both intervention groups expressed a significant reduction in overall scores of symptom severity scoring system, abdominal pain, distension, consistency, and frequency, but this reduction is greater in low FODMAP diet group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Both low FODMAP diet and GDA in patients with IBS\u2010D led to adequate improvement of gastrointestinal symptoms for 6\u00a0weeks. However, the low FODMAP diet has greater benefits in IBS improvement.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jgh.14051","type":"journal-article","created":{"date-parts":[[2017,11,21]],"date-time":"2017-11-21T01:42:37Z","timestamp":1511228557000},"page":"1192-1199","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":105,"title":["Low fermentable oligo\u2010di\u2010mono\u2010saccharides and polyols diet <i>versus<\/i> general dietary advice in patients with diarrhea\u2010predominant irritable bowel syndrome: A randomized controlled trial"],"prefix":"10.1111","volume":"33","author":[{"given":"Mohammad Javad","family":"Zahedi","sequence":"first","affiliation":[{"name":"Gastroenterology and Hepatology Research Center Kerman University of Medical Sciences  Kerman Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vahideh","family":"Behrouz","sequence":"additional","affiliation":[{"name":"Gastroenterology and Hepatology Research Center Kerman University of Medical Sciences  Kerman Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maryam","family":"Azimi","sequence":"additional","affiliation":[{"name":"Gastroenterology and Hepatology Research Center Kerman University of Medical Sciences  Kerman Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,2,21]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/jhn.12318"},{"key":"e_1_2_6_3_1","first-page":"131","article-title":"Efficacy of the low FODMAP diet for treating irritable bowel syndrome: the evidence to date","volume":"9","author":"Nanayakkara WS","year":"2016","journal-title":"Clin. 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