{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T01:28:04Z","timestamp":1789954084675,"version":"4.0.1"},"reference-count":29,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2018,2,27]],"date-time":"2018-02-27T00:00:00Z","timestamp":1519689600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2018,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Aim<\/jats:title><jats:p>Chronic hepatitis C virus (HCV), particularly genotype 1, is associated with insulin resistance (IR) and diabetes. This study evaluated the impact of HCV clearance by all\u2010oral direct\u2010acting antiviral treatments on IR and glycemic control.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Included in this prospective case\u2013control study were 133 consecutive HCV\u2010genotype 1 patients with advance liver fibrosis (F3\u2013F4) without type 2 diabetes. Sixty eight were treated with direct\u2010acting antiviral and 65 were untreated. Liver fibrosis was assessed by transient elastography. Pre\u2010treatment, end\u2010treatment, and 3\u00a0months post\u2010treatment withdrawal IR homeostasis was assessed by homeostatic model assessment (HOMA)\u2010IR, HOMA\u2010S, and HOMA\u2010<jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"https:\/\/en.wikipedia.org\/wiki\/Beta-cell\">B<\/jats:ext-link>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>At baseline, treated, and untreated patients showed similar liver fibrosis levels, HOMA\u2010IR was 4.90\u00a0\u00b1\u00a04.62 and 4.64\u00a0\u00b1\u00a05.62, respectively. HOMA\u2010IR correlated with HCV RNA levels. At the end of treatment, all patients cleared HCV RNA, regardless of liver fibrosis and body mass index, and a reduction in HOMA\u2010IR at 2.42\u00a0\u00b1\u00a01.85 was showed (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001); in addition, increased insulin sensitivity, decreased insulin secretion, reduction of serum glucose, and insulin levels were observed. Data were confirmed 3\u00a0months after treatment withdrawal in the 65 patients who cleared HCV. No variation occurred in untreated patients. Overall, 76.5% of sustained virologic response patients showed IR improvements, of which 41.2% normalized IR. Improvement of IR was strictly associated with HCV clearance; however, patients with the highest levels of fibrosis remain associated with some degree of IR.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The data underline a role of HCV in development of IR and that viral eradication reverses IR and improves glycemic control and this could prevent IR\u2010related clinical manifestations and complications.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jgh.14067","type":"journal-article","created":{"date-parts":[[2017,12,11]],"date-time":"2017-12-11T22:06:40Z","timestamp":1513030000000},"page":"1379-1382","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":76,"title":["Hepatitis C virus clearance by direct\u2010acting antiviral treatments and impact on insulin resistance in chronic hepatitis C patients"],"prefix":"10.1111","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8453-4912","authenticated-orcid":false,"given":"Luigi E","family":"Adinolfi","sequence":"first","affiliation":[{"name":"Internal Medicine, Department of Medical, Surgical, Neurological, Metabolic, and Geriatric Sciences University of Campania \u201cLuigi Vanvitelli\u201d  Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Riccardo","family":"Nevola","sequence":"additional","affiliation":[{"name":"Clinical Hospital of Marcianise ASL Caserta  Caserta Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara","family":"Guerrera","sequence":"additional","affiliation":[{"name":"Clinical Hospital of Marcianise ASL Caserta  Caserta Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni","family":"D'Alterio","sequence":"additional","affiliation":[{"name":"Internal Medicine, Department of Medical, Surgical, Neurological, Metabolic, and Geriatric Sciences University of Campania \u201cLuigi Vanvitelli\u201d  Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aldo","family":"Marrone","sequence":"additional","affiliation":[{"name":"Internal Medicine, Department of Medical, Surgical, Neurological, Metabolic, and Geriatric Sciences University of Campania \u201cLuigi Vanvitelli\u201d  Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mauro","family":"Giordano","sequence":"additional","affiliation":[{"name":"Clinical Hospital of Marcianise ASL Caserta  Caserta Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luca","family":"Rinaldi","sequence":"additional","affiliation":[{"name":"Internal Medicine, Department of Medical, Surgical, Neurological, Metabolic, and Geriatric Sciences University of Campania \u201cLuigi Vanvitelli\u201d  Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,2,27]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mam.2007.09.017"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1517\/14656566.2011.597742"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2003.08.032"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2007.11.010"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2016.09.001"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.4254\/wjh.v6.i9.677"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1186\/1472-6823-13-47"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.01683-06"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hep.2003.09.012"},{"key":"e_1_2_5_11_1","first-page":"17","article-title":"NAFLD and NASH in HCV Infection: prevalence and significance in hepatic and extrahepatic manifestations","volume":"25","author":"Adinolfi LE","year":"2016","journal-title":"Int. J. Mol. Sci"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2004.050302"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1053\/jhep.2001.24432"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1053\/jhep.2001.0103306le01"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1478-3231.2007.01626.x"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1053\/jhep.2003.50291"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2003.11.056"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2007.11.022"},{"key":"e_1_2_5_19_1","first-page":"335","article-title":"Changes in glucose tolerance after interferon\u2010alpha therapy in patients with chronic hepatitis C","volume":"28","author":"Tanaka H","year":"1997","journal-title":"J. Med."},{"key":"e_1_2_5_20_1","doi-asserted-by":"crossref","unstructured":"Delgado\u2010BorregoA JordanSH NegreBet al.Halt\u2010C Trial Group. Reduction of insulin resistance with effective clearance of hepatitis C infection: results from the HALT\u2010C trial.Clin. Gastroenterol. Hepatol.2010;8:458\u2013462.","DOI":"10.1016\/j.cgh.2010.01.022"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dld.2015.10.016"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.51.1.89"},{"key":"e_1_2_5_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.22703"},{"key":"e_1_2_5_24_1","doi-asserted-by":"publisher","DOI":"10.1136\/jim-2016-000343"},{"key":"e_1_2_5_25_1","article-title":"Significant improvement of glycaemic control in diabetic patients with HCV infection responding to direct\u2010acting antiviral agents","author":"Ciancio A","year":"2017","journal-title":"J. Med. Virol."},{"key":"e_1_2_5_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2006.03114.x"},{"key":"e_1_2_5_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2014.11.025"},{"key":"e_1_2_5_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2007.10.011"},{"key":"e_1_2_5_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.26892"},{"key":"e_1_2_5_30_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cis500"}],"container-title":["Journal of Gastroenterology and Hepatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjgh.14067","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jgh.14067","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,23]],"date-time":"2023-09-23T19:36:55Z","timestamp":1695497815000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jgh.14067"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,2,27]]},"references-count":29,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2018,7]]}},"alternative-id":["10.1111\/jgh.14067"],"URL":"https:\/\/doi.org\/10.1111\/jgh.14067","archive":["Portico"],"relation":{},"ISSN":["0815-9319","1440-1746"],"issn-type":[{"value":"0815-9319","type":"print"},{"value":"1440-1746","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,2,27]]},"assertion":[{"value":"2017-11-12","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2017-12-04","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-02-27","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}