{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T00:16:05Z","timestamp":1780445765112,"version":"3.54.1"},"reference-count":31,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2018,2,27]],"date-time":"2018-02-27T00:00:00Z","timestamp":1519689600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2018,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Aims<\/jats:title><jats:p>The incidence and disease burden of colorectal cancer (CRC) in young adults were increasing. However, there was a dearth of advice on how to identify young population at risk for neoplastic colonic polyps (NCPs) and CRC. We aimed to identify risk factors for NCPs and CRC in young adults presenting with bloody stool.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 1496 subjects younger than 40\u00a0years old who underwent colonoscopy due to bloody stool from 2005 to 2014 were enrolled in this retrospective study as the study group, and 1481 age\u2010matched and gender\u2010matched asymptomatic subjects who underwent colonoscopy for health checkup from 2011 to 2016 were enrolled as the control group at a tertiary center hospital.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Multivariate analysis results showed that increasing age (odds ratio [OR]\u00a0=\u00a01.11, 95% confidence interval [CI]: 1.07\u20131.15, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001), higher body mass index (BMI) (OR\u00a0=\u00a01.07, 95%CI: 1.03\u20131.12, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.001), diabetes mellitus (OR\u00a0=\u00a02.80, 95%CI: 1.06\u20137.42, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.038), and positive family history of CRC (OR\u00a0=\u00a013.28, 95%CI: 5.70\u201330.97, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001) were identified as independent risk factors for NCPs in study group. The best cut\u2010off values by receiver operating characteristic curve for age and BMI were 32\u00a0years old and 24.8\u00a0kg\/m<jats:sup>2<\/jats:sup>, respectively. More risk factors were associated with the higher risk for NCPs (OR\u00a0=\u00a02.17 every increasing one risk factor, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001). In the control group, no independent risk factors were identified.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Adults aged \u2264\u00a040\u00a0years with bloody stool who had increasing age (&gt;\u00a032\u00a0years old), higher BMI (&gt;\u00a024.8\u00a0kg\/m<jats:sup>2<\/jats:sup>), diabetes mellitus, and positive family history of CRC had a higher detection rate of NCPs and CRC.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jgh.14070","type":"journal-article","created":{"date-parts":[[2017,12,12]],"date-time":"2017-12-12T14:01:37Z","timestamp":1513087297000},"page":"1335-1340","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Identification of risk factors for neoplastic colonic polyps in young adults with bloody stool in comparison with those without symptom"],"prefix":"10.1111","volume":"33","author":[{"given":"Kuan\u2010Chih","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Internal Medicine Far Eastern Memorial Hospital  New Taipei City Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen\u2010Shuan","family":"Chung","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Far Eastern Memorial Hospital  New Taipei City Taiwan"},{"name":"College of Medicine Fu Jen Catholic University  New Taipei City Taiwan"},{"name":"Taiwan Association for the Study of Small Intestinal Diseases (TASSID)  Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei\u2010Fan","family":"Hsu","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine China Medical University Hospital  Taichung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tien\u2010Yu","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Far Eastern Memorial Hospital  New Taipei City Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheng\u2010Kuan","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Far Eastern Memorial Hospital  New Taipei City Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tzong\u2010Hsi","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Far Eastern Memorial Hospital  New Taipei City Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meng\u2010Tzu","family":"Weng","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Far Eastern Memorial Hospital  New Taipei City Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheng\u2010Ming","family":"Chiu","sequence":"additional","affiliation":[{"name":"Health Management Center Far Eastern Memorial Hospital  New Taipei City Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li\u2010Chun","family":"Chang","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine National Taiwan University Hospital  Taipei Taiwan"},{"name":"Graduate Institute of Clinical Medicine, College of Medicine National Taiwan University  Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Han\u2010Mo","family":"Chiu","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine National Taiwan University Hospital  Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,2,27]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21262"},{"key":"e_1_2_5_3_1","unstructured":"FerlayJ SI ErvikM et al.GLOBOCAN 2012 v1.0 Cancer incidence and mortality worldwide: IARC CancerBase No. 11 [Internet]. 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