{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T11:59:18Z","timestamp":1788263958895,"version":"build-2803163510"},"reference-count":35,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2018,3,14]],"date-time":"2018-03-14T00:00:00Z","timestamp":1520985600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"the Scientific Research Project of No.105 Hospital of PLA","award":["No.2013YG04"],"award-info":[{"award-number":["No.2013YG04"]}]},{"name":"the General project of Nanjing Military Region of PLA","award":["No.15MS048"],"award-info":[{"award-number":["No.15MS048"]}]},{"name":"the General project of Nanjing Military Region of PLA","award":["no. 15MS048"],"award-info":[{"award-number":["no. 15MS048"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2018,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Aim<\/jats:title><jats:p>The aim of our study was to investigate the immunomodulatory effect and short\u2010term efficacy and long\u2010term prognosis of decompensated liver cirrhosis patients caused by hepatitis B after a double transplantation with human umbilical cord mesenchymal stem cells (hUCMSCs).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Fifty inpatients were recruited and given the same medical treatments, receiving hUCMSCs injection intravenously. Fifty\u2010three patients (Group B) matched for age, sex, and baseline alanine aminotransferase, aspartate aminotransferase, albumin, total bilirubin, prothrombin time, and model for end\u2010stage liver disease score and Child\u2013Pugh classification, acted as the control group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Interleukin\u20106 and tumor necrosis factor alpha levels markedly decreased, and interleukin\u201010 level apparently increased in Group A at 2 and 4\u00a0weeks after treatment. Transforming growth factor beta in Group A increased more remarkably at 2\u00a0weeks after treatment. T4 cells and Treg cells in Group A were apparently higher than those in Group B at 2 and 4\u00a0weeks after treatment, and T8 cells and B cells were significantly lower than those in Group B. Aspartate aminotransferase levels in Group A were dramatically declining at 8 and 12\u00a0weeks after treatment. Levels of albumin, total bilirubin, and prothrombin time in Group A were apparently improved from 4 to 12\u00a0weeks after treatment. The improvements in model for end\u2010stage liver disease and Child\u2013Pugh scores in Group A were notably superior to those in Group B from 4 to 36\u00a0weeks after treatment. There were no remarkable differences in the incidence of developing liver failure throughout the follow\u2010up period, but the mortality rate of Group A was lower than that of Group B.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This therapeutic method may be an appropriate choice for patients with decompensated liver cirrhosis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jgh.14081","type":"journal-article","created":{"date-parts":[[2018,1,2]],"date-time":"2018-01-02T13:36:45Z","timestamp":1514900205000},"page":"774-780","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":48,"title":["A study about immunomodulatory effect and efficacy and prognosis of human umbilical cord mesenchymal stem cells in patients with chronic hepatitis B\u2010induced decompensated liver cirrhosis"],"prefix":"10.1111","volume":"33","author":[{"given":"Xueqing","family":"Fang","sequence":"first","affiliation":[{"name":"Department 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