{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,17]],"date-time":"2026-02-17T11:02:04Z","timestamp":1771326124026,"version":"3.50.1"},"reference-count":31,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2018,3,25]],"date-time":"2018-03-25T00:00:00Z","timestamp":1521936000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2018,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Aim<\/jats:title><jats:p>Few reports have demonstrated the effectiveness of treatments for intestinal follicular lymphoma (FL) because of the limited number of patients who undergo comprehensive small intestinal examinations. This study compared the efficacy of rituximab\u2010combined chemotherapy in patients with asymptomatic and low tumor burden (LTB) intestinal FL, according to the criteria of the Groupe d'Etude des Lymphomes Folliculaires, with that of a \u201cwatch and wait\u201d (W&amp;W) approach.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The endoscopic examination for entire gastrointestinal tracts was performed in 29 Japanese patients with intestinal FL. These patients had CD21\u2010positive follicular dendritic cells arranged in a duodenal pattern. In a prospective, two\u2010center, open\u2010label trial, this study evaluated the efficacy of rituximab\u2010combined chemotherapy ([cyclophosphamide, doxorubicin, vincristine, and prednisone] or [cyclophosphamide, vincristine, and prednisone]) and prolonged treatment with rituximab (R\u2010Chemo+prolongedR) in 14 patients and compared their outcomes with those of 15 patients managed with a W&amp;W approach.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Four patients managed with the W&amp;W plan showed worsening macroscopic findings, lesion area enlargement, or clinical stage progression but stayed on this plan because they had LTB and experienced no changes in bowel function. In the R\u2010Chemo+prolongedR group, all patients achieved complete remission; recurrence occurred in one patient, who was subsequently managed with the W&amp;W plan because of LTB. There were no significant differences in progression\u2010free survival between the two groups (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.1045). Overall survival was 100% in both groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The prognoses of patients with asymptomatic intestinal FL and LTB who were managed with a W&amp;W strategy were comparable with those of patients receiving R\u2010Chemo+prolongedR.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jgh.14100","type":"journal-article","created":{"date-parts":[[2018,1,29]],"date-time":"2018-01-29T21:17:44Z","timestamp":1517260664000},"page":"1461-1468","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["Watch\u2010and\u2010wait policy <i>versus<\/i> rituximab\u2010combined chemotherapy in Japanese patients with intestinal follicular lymphoma"],"prefix":"10.1111","volume":"33","author":[{"given":"Akira","family":"Tari","sequence":"first","affiliation":[{"name":"Division of Gastroenterology, Department of Internal Medicine Hiroshima Red Cross Hospital &amp; Atomic\u2010bomb Survivors Hospital  Hiroshima Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasuhiko","family":"Kitadai","sequence":"additional","affiliation":[{"name":"Department of Health and Science Prefectural University of Hiroshima  Hiroshima Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ritsuo","family":"Mouri","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Department of Internal Medicine Hiroshima Red Cross Hospital &amp; Atomic\u2010bomb Survivors Hospital  Hiroshima Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hidehiko","family":"Takigawa","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Metabolism Hiroshima University  Hiroshima Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hideki","family":"Asaoku","sequence":"additional","affiliation":[{"name":"Department of Hematology Hiroshima Red Cross Hospital &amp; Atomic\u2010bomb Survivors Hospital  Hiroshima Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keiichiro","family":"Mihara","sequence":"additional","affiliation":[{"name":"Department of Hematology and Oncology, Research Institute for Radiation Biology and Medicine Hiroshima University  Hiroshima Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katsuyoshi","family":"Takata","sequence":"additional","affiliation":[{"name":"Department of Pathology Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences  Okayama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Megumu","family":"Fujihara","sequence":"additional","affiliation":[{"name":"Department of Pathology Hiroshima Red Cross Hospital &amp; Atomic\u2010bomb Survivors Hospital  Hiroshima Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tadashi","family":"Yoshino","sequence":"additional","affiliation":[{"name":"Department of Pathology Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences  Okayama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tadashi","family":"Koga","sequence":"additional","affiliation":[{"name":"Shin Nippon Biomedical Laboratories, Ltd.  Kagoshima Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shunji","family":"Fujimori","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Chiba Hokusou Hospital, Nippon Medical School  Chiba Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shinji","family":"Tanaka","sequence":"additional","affiliation":[{"name":"Department of Endoscopy and Medicine, Graduate School of Biomedical and Health Science Hiroshima University  Hiroshima Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuaki","family":"Chayama","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Metabolism Hiroshima University  Hiroshima Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,3,25]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2005-01-0016"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2005.03.1674"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djk152"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2007.13.5376"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.25149"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1997.15.3.1110"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(03)14110-4"},{"key":"e_1_2_5_9_1","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1182\/asheducation-2007.1.216","article-title":"Clinical features, prognosis and treatment of follicular lymphoma","author":"Salles GA","year":"2007","journal-title":"Hematology Am. 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