{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T16:06:37Z","timestamp":1791648397065,"version":"4.3.4"},"reference-count":35,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2018,3,12]],"date-time":"2018-03-12T00:00:00Z","timestamp":1520812800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2018,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The association between body mass index (BMI) and mortality from gastrointestinal (GI) cancer remains unclear, especially in Asian populations.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 510\u00a0148 Korean adults who participated in routine health examinations during the period 2002\u20132003 were followed up until 2013.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>During a mean follow up of 10.5\u00a0years, 7831 individuals died of GI cancer. Various associations with BMI were found: U\u2010curve (overall GI, colorectal, liver, and gallbladder cancer), L\u2010curve (stomach cancer), linear (esophageal, extrahepatic bile duct [EBD], and small intestine cancer), and none (pancreatic cancer). Overall GI cancer mortality was lowest at approximately 23.5\u201326\u00a0kg\/m<jats:sup>2<\/jats:sup>. For cancers with linear associations, the multivariable adjusted hazard ratios per each 5\u00a0kg\/m<jats:sup>2<\/jats:sup> higher BMI were 0.53 (95% confidence interval\u00a0=\u00a00.43\u20130.65, esophagus), 1.19 (1.02\u20131.40, EBD), and 0.64 (0.41\u20130.999, small intestine). For cancers with U\u2010curve or L\u2010curve associations, the corresponding hazard ratios \u226525\u00a0kg\/m<jats:sup>2<\/jats:sup> were 1.19 (1.08\u20131.32, overall GI), 1.30 (1.04\u20131.64, colorectal), 1.28 (1.07\u20131.53, liver), and 1.30 (0.85\u20131.97, gallbladder), while in the range of &lt;25\u00a0kg\/m<jats:sup>2<\/jats:sup>, they were 0.81 (0.76\u20130.87, overall GI), 0.43 (0.32\u20130.58, esophagus), 0.70 (0.62\u20130.79, stomach), and 0.77 (0.65\u20130.90, colorectal), and these inverse associations did not weaken after excluding the first 7\u00a0years of follow up and ever smokers.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Both low and high BMIs were associated with excess mortality from GI cancers in Korean adults. EBD cancer had a positive association, while esophageal and small intestine cancers had inverse associations. Above 25\u00a0kg\/m<jats:sup>2<\/jats:sup>, liver and colorectal cancers had positive associations with BMI, whereas below 25\u00a0kg\/m<jats:sup>2<\/jats:sup>, stomach and colorectal cancers had inverse associations.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jgh.14115","type":"journal-article","created":{"date-parts":[[2018,2,21]],"date-time":"2018-02-21T20:45:32Z","timestamp":1519245932000},"page":"1582-1589","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Body mass index and gastrointestinal cancer mortality in Korean adults: A prospective cohort study"],"prefix":"10.1111","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9197-1184","authenticated-orcid":false,"given":"Seok\u2010Hoo","family":"Jeong","sequence":"first","affiliation":[{"name":"Department of Internal Medicine Catholic Kwandong University International St. Mary's Hospital  Incheon Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pumsoo","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Catholic Kwandong University International St. Mary's Hospital  Incheon Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6656-6205","authenticated-orcid":false,"given":"Sang\u2010Wook","family":"Yi","sequence":"additional","affiliation":[{"name":"Department of Preventive Medicine and Public Health Catholic Kwandong University College of Medicine  Gangneung Korea"},{"name":"Institute for Clinical and Translational Research Catholic Kwandong University  Gangneung Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu Jin","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Catholic Kwandong University International St. Mary's Hospital  Incheon Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Myong Ki","family":"Baeg","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Catholic Kwandong University International St. Mary's Hospital  Incheon Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jee\u2010Jeon","family":"Yi","sequence":"additional","affiliation":[{"name":"Institute for Occupational and Environmental Health Catholic Kwandong University  Gangneung Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,3,12]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2012.12.027"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21387"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.4143\/crt.2017.130"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(09)60318-4"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(14)60892-8"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(10)70141-8"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(08)60269-X"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.f5446"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/dyv138"},{"key":"e_1_2_6_11_1","first-page":"799","article-title":"Data resource profile: The National Health Information Database of the National Health Insurance Service in South Korea","volume":"46","author":"Seong SC","year":"2017","journal-title":"Int. J. Epidemiol."},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc16-1458"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000003684"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(03)15268-3"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000004876"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwq341"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1000367"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1010679"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2005.11.726"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.39367.495995.AE"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.23719"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6602789"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1023\/B:CACO.0000016573.79453.ba"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0120706"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.canep.2009.09.010"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.puhe.2008.04.003"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1097\/COC.0000000000000388"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1634\/theoncologist.2012-0066"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/jgh.12238"},{"key":"e_1_2_6_30_1","first-page":"8321","article-title":"Body mass index and risk of gallbladder cancer: systematic review and meta\u2010analysis of observational studies","volume":"7","author":"Tan W","year":"2015","journal-title":"Forum Nutr."},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.293.3.330"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.3109\/07853890.2012.705015"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.21683"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa021423"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000003305"},{"key":"e_1_2_6_36_1","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/291546"}],"container-title":["Journal of Gastroenterology and Hepatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjgh.14115","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jgh.14115","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,17]],"date-time":"2023-09-17T16:06:19Z","timestamp":1694966779000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jgh.14115"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,3,12]]},"references-count":35,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2018,9]]}},"alternative-id":["10.1111\/jgh.14115"],"URL":"https:\/\/doi.org\/10.1111\/jgh.14115","archive":["Portico"],"relation":{},"ISSN":["0815-9319","1440-1746"],"issn-type":[{"value":"0815-9319","type":"print"},{"value":"1440-1746","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,3,12]]},"assertion":[{"value":"2017-11-13","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-01-24","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-03-12","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}