{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T18:41:23Z","timestamp":1760985683785},"reference-count":20,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2018,5,7]],"date-time":"2018-05-07T00:00:00Z","timestamp":1525651200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"AstraZeneca China"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2018,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Aim<\/jats:title><jats:p>Empirical proton pump inhibitor (PPI) treatment is recommended as a diagnostic indicator for gastroesophageal reflux disease (GERD) and as a therapy for symptomatic control, with responses generally seen within 4\u00a0weeks. However, there are no real\u2010world data assessing the effectiveness of short\u2010term empirical treatment with PPIs in patients with GERD in China.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The ENLIGHT study was a multicenter, prospective, observational study conducted in China. The primary outcome was the overall response rate after 4\u00a0weeks' empirical treatment with PPIs. Adult patients aged between 18 and 65\u00a0years of age, with a gastroesophageal reflux disease questionnaire score of \u2265\u00a08, prescribed empirical PPI treatment by their physicians and with no planned endoscopy were eligible to participate. Statistical analyses were primarily descriptive.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Overall, 987 patients were eligible to participate and were included in the full analysis set (FAS); 707 patients were included in the per protocol set. In the FAS, esomeprazole was received by 57.1% of patients and was the most commonly used PPI. After 4\u2010week treatment, 71.1% (95% confidence interval [CI], 67.9% to 74.2%) of patients were considered responders to PPI. The response rate at the end of 2\u2010week PPI treatment reached 57.0% (95% CI, 52.5% to 61.7%). The median time to response was 13\u00a0days (95% CI, 12 to 15). Response rates at 2 and 4\u00a0weeks of the per protocol set were similar to those of the FAS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Short\u2010term empirical PPI treatment can provide an effective relief of GERD symptoms in most Chinese patients in real\u2010world practice.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jgh.14143","type":"journal-article","created":{"date-parts":[[2018,3,25]],"date-time":"2018-03-25T18:22:38Z","timestamp":1522002158000},"page":"1722-1727","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Empirical treatment of outpatients with gastroesophageal reflux disease with proton pump inhibitors: A survey of Chinese patients (the ENLIGHT Study)"],"prefix":"10.1111","volume":"33","author":[{"given":"Bin","family":"Lu","sequence":"first","affiliation":[{"name":"Department of Gastroenterology The First Affiliated Hospital of Zhejiang Chinese Medical University  Hangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ling","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Changhai Hospital  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiangbin","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology China\u2010Japan Union Hospital of Jilin University  Changchun China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bangmao","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Tianjin Medical University General Hospital  Tianjin China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoping","family":"Zou","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School  Nanjing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guijun","family":"Fei","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Peking Union Medical College Hospital  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dongfeng","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Daping Hospital, Third Military Medical University  Chongqing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xuehong","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Qinghai University Affiliated Hospital  Xining China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bin","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology The Third Affiliated Hospital, Sun Yat\u2010sen University  Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Duowu","family":"Zou","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Changhai Hospital  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,5,7]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2004.051821"},{"key":"e_1_2_7_3_1","first-page":"517","article-title":"The clinical significance of typical reflux symptoms in diagnosing gastroesophageal reflux disease","volume":"53","author":"Lin L","year":"2014","journal-title":"Zhonghua Nei Ke Za Zhi"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1746.2007.05249.x"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2016-311715"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.aidm.2015.05.002"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2010.04406.x"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2036.2003.01576.x"},{"key":"e_1_2_7_9_1","first-page":"649","article-title":"2014 Chinese expert consensus opinion of gastroesophageal reflux disease","volume":"34","author":"Chinese Society of Digestive Diseases","year":"2014","journal-title":"Chin. 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