{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T22:08:36Z","timestamp":1778796516808,"version":"3.51.4"},"reference-count":40,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2018,5,4]],"date-time":"2018-05-04T00:00:00Z","timestamp":1525392000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2018,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Aim<\/jats:title><jats:p>Acute upper gastrointestinal bleeding (UGIB) in cirrhosis is associated with significant morbidity and mortality and can be classified as acute variceal bleeding (AVB) or non\u2010variceal bleeding (NVB). Differences in mortality, hospital length of stay (LOS), and 30\u2010day readmission have yet to be determined. As such, the study aimed to evaluate differences in these clinical outcomes in cirrhotic patients admitted with UGIB.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This retrospective study included all cirrhotic patients hospitalized for UGIB who underwent upper endoscopy from July 2014 to July 2016. AVB was defined as the presence of varices on endoscopy with high\u2010risk stigmata such as cherry\u2010red spots. Mortality, intensive care unit admission, hospital LOS, and 30\u2010day hospital readmission were recorded and compared among patients with AVB and NVB.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 116 patients with cirrhosis were included, 73 with AVB and 43 with NVB. Patients with NVB were older than those with AVB (60.4\u00a0\u00b1\u00a011.1 <jats:italic>vs<\/jats:italic> 55.0\u00a0\u00b1\u00a09.5, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.006) whereas patients with AVB were more likely to have known esophageal varices (64.4% <jats:italic>vs<\/jats:italic> 37.2%, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.007). Patients with AVB and NVB had similar mortality (15.1% <jats:italic>vs<\/jats:italic> 9.3%, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.57), hospital LOS (4.9, interquartile range: 3.6\u20136.9\u00a0days <jats:italic>vs<\/jats:italic> 5.0, interquartile range: 2.7\u20138.3\u00a0days), and 30\u2010day readmission rates (19.2% <jats:italic>vs<\/jats:italic> 30.2%, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.18). Severity of clinical presentation was associated with increased LOS and overall mortality, including the need for intensive care unit admission, but these were not associated with 30\u2010day readmission rates.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>There were no differences in clinical outcomes, including mortality, in cirrhotic patients admitted with AVB and NVB.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jgh.14147","type":"journal-article","created":{"date-parts":[[2018,3,30]],"date-time":"2018-03-30T16:47:16Z","timestamp":1522428436000},"page":"1773-1779","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["Comparison of clinical outcomes between variceal and non\u2010variceal gastrointestinal bleeding in patients with cirrhosis"],"prefix":"10.1111","volume":"33","author":[{"given":"Parul","family":"Tandon","sequence":"first","affiliation":[{"name":"Division of Gastroenterology and Hepatology  Ottawa Ontario Canada"},{"name":"Division of General Internal Medicine  Ottawa Ontario Canada"},{"name":"University of Ottawa  Ottawa Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kirles","family":"Bishay","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology  Ottawa Ontario Canada"},{"name":"Division of General Internal Medicine  Ottawa Ontario Canada"},{"name":"University of Ottawa  Ottawa Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stacey","family":"Fisher","sequence":"additional","affiliation":[{"name":"Ottawa Hospital Research Institute  Ottawa Ontario Canada"},{"name":"School of Epidemiology and Public Health  Ottawa Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dominique","family":"Yelle","sequence":"additional","affiliation":[{"name":"Division of General Internal Medicine  Ottawa Ontario Canada"},{"name":"University of Ottawa  Ottawa Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ian","family":"Carrigan","sequence":"additional","affiliation":[{"name":"University of Ottawa  Ottawa Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Krista","family":"Wooller","sequence":"additional","affiliation":[{"name":"Ottawa Hospital Research Institute  Ottawa Ontario Canada"},{"name":"Division of General Internal Medicine  Ottawa Ontario Canada"},{"name":"University of Ottawa  Ottawa Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erin","family":"Kelly","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology  Ottawa Ontario Canada"},{"name":"Ottawa Hospital Research Institute  Ottawa Ontario Canada"},{"name":"Division of General Internal Medicine  Ottawa Ontario Canada"},{"name":"University of Ottawa  Ottawa Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,5,4]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2012.05140.x"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12664-016-0622-7"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/liv.12137"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2015.01.032"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.20339"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2012.451"},{"key":"e_1_2_5_8_1","first-page":"379","article-title":"Predictors of variceal or nonvariceal source of upper gastrointestinal bleeding. An etiology predictive score established and validated in a tertiary referral center","volume":"22","author":"Matei D","year":"2013","journal-title":"J. Gastrointestin. Liver Dis."},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2011.03.048"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-8278(01)68827-5"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2012.313"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1053\/jhep.2003.50385"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2012.05225.x"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-4733.2007.00208.x"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v23.i37.6868"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.21669"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/MEG.0b013e32830dfcb3"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1053\/jhep.2003.50346"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.163.2.218"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.21563"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v19.i22.3466"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2015.05.022"},{"key":"e_1_2_5_23_1","volume-title":"R Core Team: R: A Language and Environment for Statistical Computing","year":"2013"},{"key":"e_1_2_5_24_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.sla.0000231704.45005.4e"},{"key":"e_1_2_5_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2003.07294.x"},{"key":"e_1_2_5_26_1","doi-asserted-by":"publisher","DOI":"10.1053\/jhep.2002.31354"},{"key":"e_1_2_5_27_1","article-title":"Survival of patients with cirrhosis and acute peptic ulcer bleeding compared with variceal bleeding using current first\u2010line therapies","author":"Ardevol A","year":"2017","journal-title":"Hepatology"},{"key":"e_1_2_5_28_1","doi-asserted-by":"publisher","DOI":"10.4321\/S1130-01082011000400005"},{"key":"e_1_2_5_29_1","doi-asserted-by":"publisher","DOI":"10.5152\/tjg.2014.6710"},{"key":"e_1_2_5_30_1","doi-asserted-by":"publisher","DOI":"10.1053\/gast.2001.22451"},{"key":"e_1_2_5_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2011.04746.x"},{"key":"e_1_2_5_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2016.05.040"},{"key":"e_1_2_5_33_1","first-page":"240","article-title":"Factors predicting in\u2010hospital mortality in patients with cirrhosis hospitalized with gastro\u2010esophageal variceal hemorrhage","volume":"25","author":"Ismail FW","year":"2006","journal-title":"Indian J. Gastroenterol."},{"key":"e_1_2_5_34_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2002.05541.x"},{"key":"e_1_2_5_35_1","doi-asserted-by":"publisher","DOI":"10.12659\/MSM.895005"},{"key":"e_1_2_5_36_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.15.1099"},{"key":"e_1_2_5_37_1","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/349324"},{"key":"e_1_2_5_38_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.1998.00336.x"},{"key":"e_1_2_5_39_1","doi-asserted-by":"publisher","DOI":"10.1002\/jhm.606"},{"key":"e_1_2_5_40_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12876-017-0712-8"},{"key":"e_1_2_5_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(17)33963-X"}],"container-title":["Journal of Gastroenterology and Hepatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjgh.14147","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jgh.14147","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,17]],"date-time":"2023-09-17T16:05:39Z","timestamp":1694966739000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jgh.14147"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,5,4]]},"references-count":40,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2018,10]]}},"alternative-id":["10.1111\/jgh.14147"],"URL":"https:\/\/doi.org\/10.1111\/jgh.14147","archive":["Portico"],"relation":{},"ISSN":["0815-9319","1440-1746"],"issn-type":[{"value":"0815-9319","type":"print"},{"value":"1440-1746","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,5,4]]},"assertion":[{"value":"2018-02-11","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-03-12","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-05-04","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}