{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T13:37:52Z","timestamp":1762177072808},"reference-count":27,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2018,5,4]],"date-time":"2018-05-04T00:00:00Z","timestamp":1525392000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81670473"],"award-info":[{"award-number":["81670473"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2018,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Aim<\/jats:title><jats:p>Endoscopic retrograde cholangiopancreatography (ERCP) is associated with risk of complications. Methods to facilitate ductal cannulation may reduce complications. Intraduodenal acid infusion is a physiological approach to stimulate secretin release in human body and may facilitate cannulation. The objective of this study was to investigate the effect of intraduodenal acid infusion on pancreatic duct cannulation during ERCP.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>It was a single center, double\u2010blind, randomized controlled trial. Consecutive patients undergoing first ERCP for pancreatic diseases were randomized toreceive 50\u00a0mL acetic acid intraduodenal infusion at ERCP (acetic acid group) or 50\u00a0mL saline (control group). The primary outcome, difficult cannulation rate (cannulation time &gt;5\u00a0min), in the two groups was compared.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Two hundred ten patients were included in the final analysis (105 in each group). The difficult cannulation rate were 39.1% in the control group and 20.9% in the acetic acid group, and the difference was statistically significant (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.004). The overall successful deep cannulation rate was 89.5% and 85.7%, respectively (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.402). The cannulation time was remarkably shortened (182 <jats:italic>vs<\/jats:italic> 286\u00a0s, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.018), and the cannulation attempts were significantly decreased (3.4 <jats:italic>vs<\/jats:italic> 4.4, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.008). The fluoroscopy time was also significantly reduced (60 <jats:italic>vs<\/jats:italic> 86\u00a0s, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.028). The incidence of post\u2010ERCP pancreatitis and hyperamylasemia was comparable (7.6% <jats:italic>vs<\/jats:italic> 10.5% and 10.5% <jats:italic>vs<\/jats:italic> 19.1%, <jats:italic>P<\/jats:italic>\u00a0&gt;\u00a00.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Intraduodenal acetic acid infusion can significantly decrease difficult pancreatic cannulation rate, facilitate pancreatic duct cannulation, and reduce radiation exposure (<jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/clinicaltrials.gov\">ClinicalTrials.gov<\/jats:ext-link> number, NCT02800772).<\/jats:p><\/jats:sec>","DOI":"10.1111\/jgh.14148","type":"journal-article","created":{"date-parts":[[2018,4,10]],"date-time":"2018-04-10T00:30:31Z","timestamp":1523320231000},"page":"1804-1810","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Impact of intraduodenal acetic acid infusion on pancreatic duct cannulation during endoscopic retrograde cholangiopancreatography: A double\u2010blind, randomized controlled trial"],"prefix":"10.1111","volume":"33","author":[{"given":"Jun","family":"Fang","sequence":"first","affiliation":[{"name":"Department of Gastroenterology, Changhai Hospital Second Military Medical University\/Naval Medical University  Shanghai China"},{"name":"Department of Gastroenterology Zhongnan Hospital of Wuhan University  Wuhan China"},{"name":"Hubei Clinical Center and Key Laboratory of Intestinal and Colorectal Diseases  Wuhan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shu\u2010Ling","family":"Wang","sequence":"additional","affiliation":[{"name":"Digestive Endoscopy Center, Changhai Hospital Second Military Medical University\/Naval Medical University  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sheng\u2010Bing","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Changhai Hospital Second Military Medical University\/Naval Medical University  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liang\u2010Hao","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Changhai Hospital Second Military Medical University\/Naval Medical University  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun","family":"Yao","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, The Second Clinical Medical College Jinan University  Shenzhen China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhen","family":"Shen","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Changhai Hospital Second Military Medical University\/Naval Medical University  Shanghai 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