{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T18:35:10Z","timestamp":1789929310329,"version":"4.0.1"},"reference-count":59,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2018,5,10]],"date-time":"2018-05-10T00:00:00Z","timestamp":1525910400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81403009"],"award-info":[{"award-number":["81403009"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2018,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Aim<\/jats:title><jats:p>More concerns had been raised about the risk of kidney disease (KD) associated with acid\u2010suppressive drugs. But whether they could directly increase such risk remained unclear. Meta\u2010analysis was conducted to comprehensively investigate this relationship.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>PubMed, EMBASE, Cochrane Central Register of Controlled Trials, and three Chinese databases were searched until April 2017 for observational studies investigating the associations between acid\u2010suppressive drugs and KD. Pooled log (odds ratios [ORs]) or log (hazard ratios [HRs]) with standard errors for KD risk were calculated using the generic inverse variance method and random\u2010effect model.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Ten studies involving 128\u00a0020 KD patients were included. Proton pump inhibitor (PPI) therapy was associated with higher risks of acute interstitial nephritis (OR, 2.78; 95% confidence interval [CI], 1.25\u20136.17), acute kidney injury (AKI) (HR, 1.85; 95% CI, 1.33\u20132.59), chronic kidney disease (CKD) (HR, 1.47; 95% CI, 1.03\u20132.09), and end\u2010stage renal disease (ESRD) (HR, 1.61; 95% CI, 1.26\u20132.04) than non\u2010PPI therapy. Additionally, PPI significantly increased the risks of AKI (HR, 1.32; 95% CI, 1.16\u20131.51), CKD (HR, 1.28; 95% CI, 1.24\u20131.33), and ESRD (HR, 1.96; 95% CI, 1.21\u20133.17) compared with histamine 2 receptor antagonist (H<jats:sub>2<\/jats:sub>RA). Relationship between H<jats:sub>2<\/jats:sub>RA therapy and AKI (OR, 0.98; 95% CI, 0.90\u20131.07) or CKD (OR, 1.00; 95% CI, 0.89\u20131.11) was not found.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Proton pump inhibitor therapy significantly increased the risks of acute interstitial nephritis, AKI, CKD, and ESRD. Similar risks were not identified for H<jats:sub>2<\/jats:sub>RA therapy. More clinical trials are needed to confirm our findings.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jgh.14157","type":"journal-article","created":{"date-parts":[[2018,4,12]],"date-time":"2018-04-12T08:47:32Z","timestamp":1523522852000},"page":"1566-1573","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Acid\u2010suppressive drugs and risk of kidney disease: A systematic review and meta\u2010analysis"],"prefix":"10.1111","volume":"33","author":[{"given":"Tingting","family":"Qiu","sequence":"first","affiliation":[{"name":"Department of Pharmacy Peking University Third Hospital Beijing China"},{"name":"School of Basic Medicine and Clinical Pharmacy China Pharmaceutical University Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junwen","family":"Zhou","sequence":"additional","affiliation":[{"name":"Public Health Department AixMarseille University Marseille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chao","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Peking University Third Hospital Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,5,10]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(16)32064-5"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cca.2007.09.020"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa041031"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ki.5002017"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ki.5002586"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfg464"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.2008.058271"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2007.03407.x"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.5414\/CNP68065"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.kint.2016.02.007"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.9778\/cmajo.20140074"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcph.805"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1053\/ajkd.2001.25211"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(81)90837-8"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.2147\/DDDT.S130568"},{"key":"e_1_2_6_17_1","article-title":"The association between proton pump inhibitor use and the risk of adverse kidney outcomes: a systematic review and meta\u2010analysis","author":"Nochaiwong S","year":"2017","journal-title":"Nephrol. 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