{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T22:58:36Z","timestamp":1789167516429,"version":"build-2803163510"},"reference-count":34,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2018,5,17]],"date-time":"2018-05-17T00:00:00Z","timestamp":1526515200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Intramural Research Program of the National Institutes of Health, National Cancer Institute, Division of Cancer Epidemiology and Genetics"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2018,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Aim<\/jats:title>\n                    <jats:p>Inflammation plays a role in the development of both gallstones and gallbladder cancer; however, few studies have investigated the association of circulating inflammation proteins with risk of gallstones.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This study measured 13 cytokines (including 10 interleukins [ILs]) that have been associated with cancer in serum samples collected from 150 gallstone patients and 149 population\u2010based controls from Shanghai, China, in 1997\u20132001. This study estimated the associations of each cytokine, categorized into quartiles and coded as a trend, with risk of gallstones using logistic regression models adjusted for potential confounders.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Higher levels of IL\u20106, IL\u201010, IL\u201012 (p70), and IL\u201013 were associated with increased risk of gallstones (i.e.\n                      <jats:italic>P<\/jats:italic>\n                      <jats:sub>trend<\/jats:sub>\n                      \u00a0&lt;\u00a00.003, Bonferroni corrected), with odds ratios (ORs) that ranged from OR\n                      <jats:sub>\n                        highest quartile [Q4]\n                        <jats:italic>versus<\/jats:italic>\n                        lowest quartile [Q1]\n                      <\/jats:sub>\n                      \u00a0=\u00a03.2 (95% confidence interval: 1.4, 7.5) for IL\u201013 to OR\n                      <jats:sub>\n                        Q4\n                        <jats:italic>versus<\/jats:italic>\n                        Q1\n                      <\/jats:sub>\n                      \u00a0=\u00a05.7 (95% confidence interval: 2.5, 13.5) for IL\u201012 (p70). In a regression model including all four ILs, only IL\u201012 retained statistical significance (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a00.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This study found four circulating ILs that were associated with gallstones. Future studies are needed to validate the findings and evaluate the common pathway or mechanism in the development of gallbladder diseases associated with these cytokine signatures.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jgh.14265","type":"journal-article","created":{"date-parts":[[2018,4,19]],"date-time":"2018-04-19T10:31:37Z","timestamp":1524133897000},"page":"1920-1924","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":87,"title":["Association of circulating inflammation proteins and gallstone disease"],"prefix":"10.1111","volume":"33","author":[{"given":"Zhiwei","family":"Liu","sequence":"first","affiliation":[{"name":"Infections and Immunoepidemiology Branch, Division of Cancer Epidemiology and Genetics National Cancer Institute Rockville Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Troy J","family":"Kemp","sequence":"additional","affiliation":[{"name":"HPV Immunology Laboratory, Frederick National Laboratory for Cancer Research, Leidos Biomedical Research, Inc. Frederick Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu\u2010Tang","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Epidemiology Shanghai Cancer Institute Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amanda","family":"Corbel","sequence":"additional","affiliation":[{"name":"Infections and Immunoepidemiology Branch, Division of Cancer Epidemiology and Genetics National Cancer Institute Rockville Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emma E","family":"McGee","sequence":"additional","affiliation":[{"name":"Infections and Immunoepidemiology Branch, Division of Cancer Epidemiology and Genetics National Cancer Institute Rockville Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bingsheng","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of General Surgery, Zhongshan Hospital, School of Medicine Fudan University Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming\u2010Chang","family":"Shen","sequence":"additional","affiliation":[{"name":"Department of Pathology, Shanghai Cancer Center Fudan University Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asif","family":"Rashid","sequence":"additional","affiliation":[{"name":"Department of Pathology The University of Texas MD Anderson Cancer Center Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ann W","family":"Hsing","sequence":"additional","affiliation":[{"name":"Stanford Cancer Institute Palo Alto California USA"},{"name":"Stanford Prevention Research Center, Department of Medicine Stanford School of Medicine Palo Alto California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Allan","family":"Hildesheim","sequence":"additional","affiliation":[{"name":"Infections and Immunoepidemiology Branch, Division of Cancer Epidemiology and Genetics National Cancer Institute Rockville Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruth M","family":"Pfeiffer","sequence":"additional","affiliation":[{"name":"Biostatistics Branch, Division of Cancer Epidemiology and Genetics National Cancer Institute Rockville Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ligia A","family":"Pinto","sequence":"additional","affiliation":[{"name":"HPV Immunology Laboratory, Frederick National Laboratory for Cancer Research, Leidos Biomedical Research, Inc. 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