{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T19:42:27Z","timestamp":1770838947436,"version":"3.50.1"},"reference-count":41,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2018,6,27]],"date-time":"2018-06-27T00:00:00Z","timestamp":1530057600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Takeda (Thailand), Ltd."},{"name":"The Gastroenterological Association of Thailand"},{"name":"Chalermprakiat Grant"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2018,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Aim<\/jats:title><jats:p>Eradication rates of <jats:italic>Helicobacter pylori<\/jats:italic> following standard triple therapy are declining worldwide, but high\u2010dose proton pump inhibitor\u2010based triple therapy (HD\u2010PPI\u2010TT) and sequential therapy (ST) have demonstrated higher cure rates. We aimed to compare the efficacy and tolerability of HD\u2010PPI\u2010TT and ST in <jats:styled-content style=\"fixed-case\"><jats:italic>H.\u00a0pylori<\/jats:italic><\/jats:styled-content>\u2010associated functional dyspepsia (FD).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>One hundred and twenty <jats:styled-content style=\"fixed-case\"><jats:italic>H.\u00a0pylori<\/jats:italic><\/jats:styled-content>\u2010associated functional dyspepsia patients were randomized to receive 10\u2010day HD\u2010PPI\u2010TT (60\u00a0mg lansoprazole\/500\u00a0mg clarithromycin\/1\u00a0g amoxicillin, each administered twice daily for 10\u00a0days) or 10\u2010day ST (30\u00a0mg lansoprazole\/1\u00a0g amoxicillin, each administered twice daily for 5\u00a0days followed by 30\u00a0mg lansoprazole\/500\u00a0mg clarithromycin\/400\u00a0mg metronidazole, each administered twice daily for 5\u00a0days). <jats:styled-content style=\"fixed-case\"><jats:italic>H.\u00a0pylori<\/jats:italic><\/jats:styled-content> status was determined in post\u2010treatment week 4 by <jats:sup>14<\/jats:sup>C\u2010urea breath test. Eradication and antibiotic resistance rates, dyspeptic symptoms, drug compliance, and adverse effects were compared.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Intention\u2010to\u2010treat eradication rates were similar in the ST and HD\u2010PPI\u2010TT groups (85% vs. 80%; <jats:italic>P<\/jats:italic>\u00a0=\u00a00.47). However, the eradication rate was significantly higher following ST compared with HD\u2010PPI\u2010TT in per protocol analysis (94.4% vs. 81.4%; <jats:italic>P<\/jats:italic>\u00a0=\u00a00.035). ST achieved higher cure rates than HD\u2010PPI\u2010TT in clarithromycin\u2010resistant <jats:styled-content style=\"fixed-case\"><jats:italic>H.\u00a0pylori<\/jats:italic><\/jats:styled-content> strains (100% vs. 33.3%; <jats:italic>P<\/jats:italic>\u00a0=\u00a00.02). Treatment compliance was similar in the HD\u2010PPI\u2010TT and ST groups, although nausea and dizziness were more common in the ST group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Sequential therapy achieved better <jats:styled-content style=\"fixed-case\"><jats:italic>H.\u00a0pylori<\/jats:italic><\/jats:styled-content> eradication than HD\u2010PPI\u2010TT in patients with FD. However, the eradication rate for ST fell from 94.4% in per protocol to 85% in intention\u2010to\u2010treat analysis. Adverse effects might result in poorer compliance and compromise actual ST efficacy (ClinicalTrials.gov: NCT01888237).<\/jats:p><\/jats:sec>","DOI":"10.1111\/jgh.14292","type":"journal-article","created":{"date-parts":[[2018,5,27]],"date-time":"2018-05-27T23:49:48Z","timestamp":1527464988000},"page":"1822-1828","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Ten\u2010day high\u2010dose proton pump inhibitor triple therapy versus sequential therapy for <i>Helicobacter pylori<\/i> eradication"],"prefix":"10.1111","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5314-9966","authenticated-orcid":false,"given":"Chonticha","family":"Auesomwang","sequence":"first","affiliation":[{"name":"Division of Gastroenterology, Department of Medicine, Faculty of Medicine Siriraj Hospital  Bangkok Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Monthira","family":"Maneerattanaporn","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Department of Medicine, Faculty of Medicine Siriraj Hospital  Bangkok Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William D","family":"Chey","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Department of Medicine University of Michigan  Ann Arbor Michigan USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pattarachai","family":"Kiratisin","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Faculty of Medicine Siriraj Hospital  Bangkok Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Somchai","family":"Leelakusolwong","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Department of Medicine, Faculty of Medicine Siriraj Hospital  Bangkok Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tawesak","family":"Tanwandee","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Department of Medicine, Faculty of Medicine Siriraj Hospital  Bangkok Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,6,27]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra020542"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2007.07.008"},{"key":"e_1_2_6_4_1","first-page":"1","volume-title":"Guidelines for the Management of Dyspepsia and Helicobacter pylori","author":"Gastroenterology Association of Thailand","year":"2010"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1746.2009.05982.x"},{"key":"e_1_2_6_6_1","first-page":"74","article-title":"Efficacy of clarithromycin\u2010based triple therapy for treating Helicobacter pylori in Thai non\u2010ulcer dyspeptic patients with clarithromycin\u2010resistant strains","volume":"89","author":"Mahachai V","year":"2006","journal-title":"J. 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