{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,24]],"date-time":"2026-01-24T08:11:50Z","timestamp":1769242310638,"version":"3.49.0"},"reference-count":41,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2018,6,25]],"date-time":"2018-06-25T00:00:00Z","timestamp":1529884800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2018,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Currently, it is still unclear whether adding a mucoprotective agent to a proton pump inhibitor (PPI) results in better outcomes compared with using a PPI alone in patients with post\u2010gastric endoscopic submucosal dissection (ESD) ulcers. This study aimed to examine the efficacy of PPI alone<jats:italic>versus<\/jats:italic>combination treatment in healing of post\u2010gastric ESD ulcers, as well as on delayed bleeding and amount of blood transfused.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A systematic search of MEDLINE, EMBASE, Cochrane, and ISI Web of knowledge databases, up until May 2017, for randomized trials comparing PPI alone<jats:italic>versus<\/jats:italic>PPI plus a mucoprotective drug in achieving ulcer healing in patients undergoing gastric ESD was performed. The primary outcome is scarring stage on endoscopic assessment at 4 or 8\u00a0weeks after gastric ESD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>From an initial 3071 citations, eight articles (<jats:italic>n<\/jats:italic>\u00a0=\u00a0953 lesions from 934 patients) were analyzed. Patients receiving combination treatment achieved a scarring stage significantly more often than those on a PPIs alone at 4 or 8\u00a0weeks after ESD, (risk ratio\u00a0=\u00a01.36, 95% CI; 1.06\u20131.75). No study reported amount of blood transfused. There were no significant between treatment\u2010group differences in terms of delayed bleeding (risk ratio\u00a0=\u00a00.58, 95% CI; 0.17\u20131.99). Neither location of ulcer nor<jats:italic>Helicobacter pylori<\/jats:italic>infection was related to ulcer scarring stage.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The limited evidences suggested combination treatment may be more effective in accelerating the process of ulcer healing in patients undergoing gastric ESD than the use of PPI alone, but does not appear to alter delayed bleeding risk.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jgh.14305","type":"journal-article","created":{"date-parts":[[2018,6,5]],"date-time":"2018-06-05T18:06:56Z","timestamp":1528222016000},"page":"1948-1955","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Role of mucoprotective agents in endoscopic submucosal dissection\u2010derived ulcers: A systematic review"],"prefix":"10.1111","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6407-5245","authenticated-orcid":false,"given":"Rapat","family":"Pittayanon","sequence":"first","affiliation":[{"name":"Division of Gastroenterology McGill University and the McGill University Health Centre Montreal Canada"},{"name":"Division of Gastroenterology, Department of Medicine, Faculty of Medicine Chulalongkorn University and King Chulalongkorn Memorial Hospital the Thai Red Cross Bangkok Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Myriam","family":"Martel","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology McGill University and the McGill University Health Centre Montreal Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alan","family":"Barkun","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology McGill University and the McGill University Health Centre Montreal Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,6,25]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10120-011-0085-6"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gie.2005.10.038"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1177\/2050640615588023"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2009.115"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.162.2.169"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2007.01197.x"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1159\/000331138"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01309404"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00535-007-2076-2"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1746.1994.tb01263.x"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2125.1993.tb00374.x"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1586\/egh.10.25"},{"key":"e_1_2_7_14_1","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1016\/S0022-3565(25)12077-6","article-title":"Roles of prostaglandins, nitric oxide and the capsaicin\u2010sensitive sensory nerves in gastroprotection produced by ecabet sodium","volume":"275","author":"Kinoshita M","year":"1995","journal-title":"J. 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