{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T15:43:46Z","timestamp":1773675826592,"version":"3.50.1"},"reference-count":24,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2018,7,4]],"date-time":"2018-07-04T00:00:00Z","timestamp":1530662400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Korea Health Technology R&D Project through the Korea Health Industry Development Institute","award":["HI15C1532"],"award-info":[{"award-number":["HI15C1532"]}]},{"name":"Korea Health Technology R&D Project through the Korea Health Industry Development Institute","award":["HI15C2364"],"award-info":[{"award-number":["HI15C2364"]}]},{"name":"Korea Health Technology R&D Project through the Korea Health Industry Development Institute","award":["HI17C1365"],"award-info":[{"award-number":["HI17C1365"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2019,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Aim<\/jats:title><jats:p>To investigate prognostic value of varices on computed tomography (CT) and redefine surrogate criteria for clinically significant portal hypertension (CSPH).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We retrospectively enrolled 241 patients with compensated cirrhosis who underwent hepatic venous pressure gradient (HVPG) measurement from 2008 to 2013. Using CT and upper endoscopy findings obtained within 3\u00a0months from HVPG measurement, patients were classified into three groups: presence of standard surrogate for CSPH, defined as presence of varices on upper endoscopy and\/or splenomegaly associated with thrombocytopenia (Group 1, <jats:italic>n<\/jats:italic>\u00a0=\u00a0139); varices on CT without standard surrogate for CSPH (Group 2, <jats:italic>n<\/jats:italic>\u00a0=\u00a041); and free from both (Group 3, <jats:italic>n<\/jats:italic>\u00a0=\u00a061). HVPG value and overall survival (OS) rates were compared among three patient groups. Revised surrogate for CSPH was defined as presence of standard surrogate and\/or presence of varices on CT (i.e. both Group 1 and Group 2).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Mean HVPG value in Group 2 was significantly higher than that in Group 3 (10.3\u00a0mmHg vs 6.5\u00a0mmHg, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001), but significantly lower than that in Group 1 (10.3\u00a0mmHg vs 13.1\u00a0mmHg, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001). Seven\u2010year OS rates in Group 2 was similar to those in Group 1 (57.0% vs 62.7%, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.591), but significantly poorer than those in Group 3 (57.0% vs 84.0%, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.015). The presence of revised surrogate for CSPH was a significant predictive factor for OS (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.025, Hazard ratio\u00a0=\u00a02.71 [1.14\u20136.45]) on multivariate analysis whereas standard surrogate for CSPH was not (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.849).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The presence of varices on CT was a significant sign for CSPH, predicting poor OS outcome in patients with compensated cirrhosis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jgh.14319","type":"journal-article","created":{"date-parts":[[2018,6,14]],"date-time":"2018-06-14T07:24:15Z","timestamp":1528961055000},"page":"450-457","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Varices on computed tomography are surrogate of clinically significant portal hypertension and can predict survival in compensated cirrhosis patients"],"prefix":"10.1111","volume":"34","author":[{"given":"Dong Ho","family":"Lee","sequence":"first","affiliation":[{"name":"Department of Radiology Seoul National University Hospital  Seoul South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jhii\u2010Hyun","family":"Ahn","sequence":"additional","affiliation":[{"name":"Department of Radiology Yonsei University Wonju College of Medicine  Wonju Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jin Wook","family":"Chung","sequence":"additional","affiliation":[{"name":"Department of Radiology Seoul National University Hospital  Seoul South Korea"},{"name":"Institute of Radiation Medicine Seoul National University College of Medicine  Seoul South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Young Ju","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Radiology Yonsei University Wonju College of Medicine  Wonju Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seung\u2010Whan","family":"Cha","sequence":"additional","affiliation":[{"name":"Department of Radiology Yonsei University Wonju College of Medicine  Wonju Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Moon Young","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Yonsei University Wonju College of Medicine  Wonju Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Soon Koo","family":"Baik","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Yonsei University Wonju College of Medicine  Wonju Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,7,4]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2015.05.022"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(96)70070-7"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.510300629"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.27431"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.1840080205"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2011.07.005"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.3350\/cmh.2016.0059"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.3350\/cmh.2014.20.1.6"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.24129"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.24199"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2011.12.001"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2423050784"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.2214\/AJR.05.1737"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.22219"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2005.10.013"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.20062"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.25752"},{"key":"e_1_2_5_19_1","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/S0889-8553(21)00177-1","article-title":"Methods to evaluate portal hypertension","volume":"21","author":"Lebrec D","year":"1992","journal-title":"Gastroenterol. 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