{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:43:18Z","timestamp":1790815398320,"version":"4.1.0"},"reference-count":26,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2018,7,27]],"date-time":"2018-07-27T00:00:00Z","timestamp":1532649600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2019,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aims<\/jats:title><jats:p>The aims of this study were to better define the relationship between irritable bowel syndrome (IBS) and psychiatric disorders and to examine the efficacy of paroxetine in the treatment of IBS patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>One hundred fifty subjects with diagnosis of IBS (Roma III criteria) and relative sub\u2010classification (constipated, diarrhea, and mixed) were assessed for psychopathological features and gastrointestinal symptoms using IBS Symptom Severity Score and were <jats:italic>consecutively enrolled<\/jats:italic>. Fifty patients assumed paroxetine for 16\u00a0weeks and were longitudinally evaluated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The entire sample had a moderate\/severe gastrointestinal symptomatology (IBS\u2010SSS 285.1\u00a0\u00b1\u00a098.6). The IBS subtypes were diarrhea (47.3%), constipated (32%), and mixed (20.7%). Panic disorder was found in 17.4% and major depressive episode in 14.7%. More than 50% of the patients showed \u201cpsychopathological features.\u201d This group showed more severe gastrointestinal symptoms and worse quality of life than the group without any psychiatric comorbidity (44%). Psychiatric patients also showed a significant impairment of physical state, subjective feeling of well\u2010being, and leisure activities when compared with no psychiatric patients. When the IBS\u2010SSS\u00a0&gt;\u00a0300 group was subgrouped in psychiatric (67.2%) and no psychiatric (32.8%), we found significant differences in all clinician\u2010administered and self\u2010reported scales with more severe psychopathological features in psychiatric group (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.01). Among the patients treated with paroxetine, 34 (68%) completed the longitudinal evaluation showing a significant improvement of both psychiatric and gastrointestinal symptoms.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This study confirms a high presence of psychiatric comorbidities, emphasizing the need for psychiatric screening in all patients with IBS; moreover, the longitudinal evaluation of patients treated with paroxetine showed a significant improvement of both psychiatric and gastrointestinal symptoms.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jgh.14375","type":"journal-article","created":{"date-parts":[[2018,7,4]],"date-time":"2018-07-04T03:44:34Z","timestamp":1530675874000},"page":"713-719","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":49,"title":["The complex interplay between gastrointestinal and psychiatric symptoms in irritable bowel syndrome: A longitudinal assessment"],"prefix":"10.1111","volume":"34","author":[{"given":"Cristina","family":"Stasi","sequence":"first","affiliation":[{"name":"Internal Medicine and Liver Unit, Department of Experimental and Clinical Medicine Careggi University Hospital  Florence Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Caserta","sequence":"additional","affiliation":[{"name":"Psychiatry Unit, Department of Clinical and Experimental Medicine University of Pisa  Pisa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristiana","family":"Nisita","sequence":"additional","affiliation":[{"name":"Psychiatry Unit, Department of Clinical and Experimental Medicine University of Pisa  Pisa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sonia","family":"Cortopassi","sequence":"additional","affiliation":[{"name":"Psychiatry Unit, Department of Clinical and Experimental Medicine University of Pisa  Pisa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernardo","family":"Fani","sequence":"additional","affiliation":[{"name":"Gastrointestinal Unit, Department of Clinical and Experimental Medicine University of Pisa  Pisa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefano","family":"Salvadori","sequence":"additional","affiliation":[{"name":"Institute of Clinical Physiology, CNR  Pisa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Pancetti","sequence":"additional","affiliation":[{"name":"Gastrointestinal Unit, Department of Clinical and Experimental Medicine University of Pisa  Pisa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lorenzo","family":"Bertani","sequence":"additional","affiliation":[{"name":"Gastrointestinal Unit, Department of Clinical and Experimental Medicine University of Pisa  Pisa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dario","family":"Gambaccini","sequence":"additional","affiliation":[{"name":"Gastrointestinal Unit, Department of Clinical and Experimental Medicine University of Pisa  Pisa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicola","family":"de Bortoli","sequence":"additional","affiliation":[{"name":"Gastrointestinal Unit, Department of Clinical and Experimental Medicine University of Pisa  Pisa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liliana","family":"Dell'Osso","sequence":"additional","affiliation":[{"name":"Psychiatry Unit, Department of Clinical and Experimental Medicine University of Pisa  Pisa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Corrado","family":"Blandizzi","sequence":"additional","affiliation":[{"name":"Department of Clinical and Experimental Medicine University of Pisa  Pisa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Santino","family":"Marchi","sequence":"additional","affiliation":[{"name":"Gastrointestinal Unit, Department of Clinical and Experimental Medicine University of Pisa  Pisa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Massimo","family":"Bellini","sequence":"additional","affiliation":[{"name":"Gastrointestinal Unit, Department of Clinical and Experimental Medicine University of Pisa  Pisa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,7,27]]},"reference":[{"key":"e_1_2_4_2_1","first-page":"181","article-title":"Epidemiology of functional gastrointestinal disorders in Japan and in the world","volume":"22","author":"Oshima T","year":"2015","journal-title":"J. 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