{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T20:16:48Z","timestamp":1789503408346,"version":"build-2803163510"},"reference-count":32,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2018,8,2]],"date-time":"2018-08-02T00:00:00Z","timestamp":1533168000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Soonchunhyang University Research Fund"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2019,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Aim<\/jats:title><jats:p>The <jats:italic>Helicobacter pylori<\/jats:italic> eradication rate using conventional triple therapy has decreased due to clarithromycin (CAM) resistance in <jats:styled-content style=\"fixed-case\"><jats:italic>H.\u00a0pylori<\/jats:italic><\/jats:styled-content>. Recently, dual priming oligonucleotide (DPO)\u2010based multiplex polymerase chain reaction (PCR) can be used to detect <jats:italic>H<jats:styled-content style=\"fixed-case\">.\u00a0p<\/jats:styled-content>ylori<\/jats:italic> and point mutations in the 23S ribosomal RNA gene causing CAM resistance. This study aimed to evaluate the success rate and cost\u2010effectiveness of tailored <jats:styled-content style=\"fixed-case\"><jats:italic>H.\u00a0pylori<\/jats:italic><\/jats:styled-content> eradication using DPO\u2010PCR.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The <jats:styled-content style=\"fixed-case\"><jats:italic>H.\u00a0pylori<\/jats:italic><\/jats:styled-content>\u2010positive patients diagnosed by a rapid urease test or DPO\u2010PCR were enrolled from a single academic hospital. The patients with positive rapid urease test results received a CAM\u2010based triple regimen. In the tailored therapy group that underwent DPO\u2010PCR testing, patients with A2142G and\/or A2143G point mutations were treated with a bismuth\u2010containing quadruple regimen. The cost\u2010effectiveness of <jats:styled-content style=\"fixed-case\"><jats:italic>H.\u00a0pylori<\/jats:italic><\/jats:styled-content> eradication success was evaluated according to the average cost per patient and the incremental cost\u2010effectiveness ratio.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 243 patients were allocated to the triple therapy group and 124 patients to the tailored therapy group. The first\u2010line eradication rate of <jats:styled-content style=\"fixed-case\"><jats:italic>H.\u00a0pylori<\/jats:italic><\/jats:styled-content> was significantly higher in the tailored therapy group than in the conventional triple therapy group (92.7% <jats:italic>vs<\/jats:italic> 76.5%, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001). The average costs per patient for tailored therapy were $307.37 and $299.59 for first\u2010line and second\u2010line treatments, respectively. Compared with triple therapy, the incremental cost\u2010effectiveness ratios of tailored therapy were $3.96 and \u2212$3.81 per patient for first\u2010line and second\u2010line treatments, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In Korea, tailored <jats:styled-content style=\"fixed-case\"><jats:italic>H.\u00a0pylori<\/jats:italic><\/jats:styled-content> eradication using DPO\u2010PCR may be more cost\u2010effective than conventional triple therapy.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jgh.14383","type":"journal-article","created":{"date-parts":[[2018,7,16]],"date-time":"2018-07-16T15:50:36Z","timestamp":1531756236000},"page":"700-706","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":70,"title":["Cost\u2010effectiveness of a tailored <i>Helicobacter pylori<\/i> eradication strategy based on the presence of a 23<scp>S<\/scp> ribosomal RNA point mutation that causes clarithromycin resistance in Korean patients"],"prefix":"10.1111","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2075-2333","authenticated-orcid":false,"given":"Jun\u2010Hyung","family":"Cho","sequence":"first","affiliation":[{"name":"Digestive Disease Center Soonchunhyang University Hospital  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seong Ran","family":"Jeon","sequence":"additional","affiliation":[{"name":"Digestive Disease Center Soonchunhyang University Hospital  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyun Gun","family":"Kim","sequence":"additional","affiliation":[{"name":"Digestive Disease Center Soonchunhyang University Hospital  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"So\u2010Young","family":"Jin","sequence":"additional","affiliation":[{"name":"Department of Pathology Soonchunhyang University Hospital  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suyeon","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Medical Biostatistics Soonchunhyang University Hospital  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,8,2]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199104113241507"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa001999"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199510123331508"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(08)61159-9"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00535-013-0897-8"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2009.192757"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1746.2009.05982.x"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/hel.12279"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.3346\/jkms.2014.29.5.704"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00033-06"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1523-5378.2009.00654.x"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jit287"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1523-5378.2009.00738.x"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2003.022111"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2016-312288"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/hel.12031"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/jgh.12607"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2014.222"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1590-8658(03)00081-1"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.50.3.285"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(06)70627-2"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.41.1.397-402.2003"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-144-2-200601170-00006"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.45.5.1500-1504.2001"},{"key":"e_1_2_6_26_1","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1097\/MCG.0b013e3181d04592","article-title":"Change in antibiotic resistance of Helicobacter pylori strains and the effect of A2143G point mutation of 23S rRNA on the eradication of H. pylori in a single center of Korea","volume":"44","author":"Hwang TJ","year":"2010","journal-title":"J. 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