{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,6]],"date-time":"2025-07-06T06:40:08Z","timestamp":1751784008754,"version":"3.41.0"},"reference-count":47,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2018,8,16]],"date-time":"2018-08-16T00:00:00Z","timestamp":1534377600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Hualien, Taiwan","award":["TCRD 105-08"],"award-info":[{"award-number":["TCRD 105-08"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2019,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Aim<\/jats:title><jats:p>Acute esophageal acid infusion promotes distension\u2010induced secondary peristalsis. The gamma\u2010aminobutyric acid receptor type B (GABA\u2010B) receptors activation inhibits secondary peristalsis. This study aimed to test the hypothesis whether acid excitation of secondary peristalsis can be influenced by baclofen.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Secondary peristalsis was performed with intra\u2010esophageal slow and rapid air injections in 13 healthy subjects. Direct esophageal infusion of 0.1\u00a0N HCl following pretreatment with placebo or baclofen was randomly performed at least 1\u00a0week apart. Symptom intensity, distension thresholds, and peristaltic parameters were determined and compared between each study protocol.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The intensity of heartburn symptom in response to esophageal acid infusion was significantly greater with baclofen than the placebo (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.002). The threshold volume of secondary peristalsis during slow air injections in response to acid infusion was significantly greater with baclofen than the placebo (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.001). Baclofen significantly increased the threshold volume of secondary peristalsis during rapid air injections in response to acid infusion (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.001). The frequency of secondary peristalsis in response to acid infusion was significantly decreased by baclofen as compared with the placebo (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.001). Baclofen significantly decreased peristaltic amplitudes in response to acid infusion during rapid air injections (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.007).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Gamma\u2010aminobutyric acid receptor type B agonist baclofen inhibits acid excitation of secondary peristalsis in human esophagus, which is probably mediated by both muscular and mucosal mechanoreceptors. This work supports the evidence of potential involvement of GABA\u2010B receptors in negative modulation of acid excitation of esophageal perception as well as secondary peristalsis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jgh.14404","type":"journal-article","created":{"date-parts":[[2018,8,3]],"date-time":"2018-08-03T14:16:34Z","timestamp":1533305794000},"page":"370-375","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Gamma\u2010aminobutyric acid receptor type B agonist baclofen inhibits acid\u2010induced excitation of secondary peristalsis but not heartburn sensation"],"prefix":"10.1111","volume":"34","author":[{"given":"Ming\u2010Wun","family":"Wong","sequence":"first","affiliation":[{"name":"Department of Medicine, Hualien Tzu Chi Hospital Buddhist Tzu Chi Medical Foundation and Tzu Chi University"},{"name":"PhD Program in Pharmacology and Toxicology Tzu Chi University Hualien Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jui\u2010Sheng","family":"Hung","sequence":"additional","affiliation":[{"name":"Department of Medicine, Hualien Tzu Chi Hospital Buddhist Tzu Chi Medical Foundation and Tzu Chi University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tso\u2010Tsai","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Medicine, Hualien Tzu Chi Hospital Buddhist Tzu Chi Medical Foundation and Tzu Chi University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chih\u2010Hsun","family":"Yi","sequence":"additional","affiliation":[{"name":"Department of Medicine, Hualien Tzu Chi Hospital Buddhist Tzu Chi Medical Foundation and Tzu Chi University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei\u2010Yi","family":"Lei","sequence":"additional","affiliation":[{"name":"Department of Medicine, Hualien Tzu Chi Hospital Buddhist Tzu Chi Medical Foundation and Tzu Chi University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9084-8210","authenticated-orcid":false,"given":"Chien\u2010Lin","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Medicine, Hualien Tzu Chi Hospital Buddhist Tzu Chi Medical Foundation and Tzu Chi University"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,8,16]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198402023100503"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.35.2.152"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00388.2004"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.35.11.1523"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.36.4.499"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1159\/000201316"},{"key":"e_1_2_6_8_1","first-page":"E359","article-title":"Effect of thoracic vagotomy and vagal stimulation on esophageal function","volume":"234","author":"Kravitz JJ","year":"1978","journal-title":"Am. 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