{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,27]],"date-time":"2026-06-27T23:14:29Z","timestamp":1782602069150,"version":"3.54.5"},"reference-count":36,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2018,8,23]],"date-time":"2018-08-23T00:00:00Z","timestamp":1534982400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2019,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Aim<\/jats:title><jats:p>This study aimed to identify predictors of model for end\u2010stage liver disease sodium score reductions and improvements in vital prognoses following portosystemic shunt occlusion in portal hypertension patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Seventy cirrhotic patients with major portosystemic shunts and a mean model for end\u2010stage liver disease sodium score of 10.5 underwent balloon\u2010occluded retrograde transvenous obliteration between February 2008 and March 2017. We calculated the scores before and 1\u00a0month after shunt occlusion. The long\u2010term outcomes were monitored, and vital prognoses were analyzed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The model for end\u2010stage liver disease sodium score did not change significantly 1\u00a0month post\u2010balloon\u2010occluded retrograde transvenous obliteration, and the score decreased postoperatively in 31 (44.3%) patients. Univariate analyses showed that decline in the score after portosystemic shunt occlusion was strongly associated with hepatic encephalopathy as a procedural indication, lower liver volumes, and lower liver stiffness levels measured by transient elastography before treatment (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.05). Multivariate logistic regression analysis identified preoperative liver stiffness level as an independent predictor of model for end\u2010stage liver disease sodium score amelioration following balloon\u2010occluded retrograde transvenous obliteration (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.05), and receiver operating characteristic curve analysis determined a liver stiffness cutoff value of 21.6\u00a0kPa, with a sensitivity of 76.0% and specificity of 69.6%. The Kaplan\u2013Meier method determined that overall survival rates after treatment in patients with liver stiffness &lt;\u00a021.6\u00a0kPa were significantly higher than in patients with liver stiffness \u2265\u00a021.6\u00a0kPa (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Liver stiffness measured by transient elastography may predict improvements in model for end\u2010stage liver disease sodium scores and in survival rates after portosystemic shunt occlusion in portal hypertension patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jgh.14410","type":"journal-article","created":{"date-parts":[[2018,8,6]],"date-time":"2018-08-06T21:42:03Z","timestamp":1533591723000},"page":"215-223","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Liver stiffness measured by transient elastography as predictor of prognoses following portosystemic shunt occlusion"],"prefix":"10.1111","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3722-3083","authenticated-orcid":false,"given":"Tsuyoshi","family":"Ishikawa","sequence":"first","affiliation":[{"name":"Department of Gastroenterology and Hepatology Yamaguchi University Graduate School of Medicine  Ube Yamaguchi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryo","family":"Sasaki","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Yamaguchi University Graduate School of Medicine  Ube Yamaguchi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatsuro","family":"Nishimura","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Yamaguchi University Graduate School of Medicine  Ube Yamaguchi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takashi","family":"Matsuda","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Yamaguchi University Graduate School of Medicine  Ube Yamaguchi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masaki","family":"Maeda","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Yamaguchi University Graduate School of Medicine  Ube Yamaguchi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takuya","family":"Iwamoto","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Yamaguchi University Graduate School of Medicine  Ube Yamaguchi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Issei","family":"Saeki","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Yamaguchi University Graduate School of Medicine  Ube Yamaguchi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isao","family":"Hidaka","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Yamaguchi University Graduate School of Medicine  Ube Yamaguchi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taro","family":"Takami","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Yamaguchi University Graduate School of Medicine  Ube Yamaguchi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isao","family":"Sakaida","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Yamaguchi University Graduate School of Medicine  Ube Yamaguchi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,8,23]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1746.1996.tb00010.x"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.211.2.r99ma25349"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1051-0443(07)61912-5"},{"key":"e_1_2_6_5_1","first-page":"1026","article-title":"Changes in liver function parameters after occlusion of gastrorenal shunts with balloon\u2010occluded retrograde transvenous obliteration","volume":"92","author":"Akahane T","year":"1997","journal-title":"Am. J. Gastroenterol."},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11604-006-2407-x"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1746.2010.06262.x"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/jgh.12508"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/jgh.13382"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1053\/jhep.2001.22172"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.52.1.134"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2004.02.010"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1478-3231.2008.01803.x"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/lt.20329"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2006.02.010"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1177\/1538574413485646"},{"key":"e_1_2_6_17_1","volume-title":"The General Rules for the Clinical and Pathological Study of Primary Liver Cancer","author":"The Liver Cancer Study Group of Japan","year":"2015"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00535-013-0893-z"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.2214\/AJR.16.17307"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1053\/jhep.2003.50346"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.21669"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0301-5629(02)00489-1"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.tvir.2013.02.004"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.2214\/ajr.184.4.01841340"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00535-007-2077-1"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00270-013-0807-8"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2007.01466.x"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12072-008-9091-0"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2011.01.051"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvir.2016.03.031"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.surg.2017.06.006"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/0168-8278(89)90169-4"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/0168-8227(93)90130-W"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.51.1.100"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2006.107946"},{"key":"e_1_2_6_36_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1478-3231.2009.02043.x"},{"key":"e_1_2_6_37_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1005461611262"}],"container-title":["Journal of Gastroenterology and Hepatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjgh.14410","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jgh.14410","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,14]],"date-time":"2023-09-14T23:13:51Z","timestamp":1694733231000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jgh.14410"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,8,23]]},"references-count":36,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2019,1]]}},"alternative-id":["10.1111\/jgh.14410"],"URL":"https:\/\/doi.org\/10.1111\/jgh.14410","archive":["Portico"],"relation":{},"ISSN":["0815-9319","1440-1746"],"issn-type":[{"value":"0815-9319","type":"print"},{"value":"1440-1746","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,8,23]]},"assertion":[{"value":"2018-05-21","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-07-25","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-08-23","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}