{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,9,15]],"date-time":"2023-09-15T09:55:34Z","timestamp":1694771734896},"reference-count":47,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2018,10,3]],"date-time":"2018-10-03T00:00:00Z","timestamp":1538524800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Katsuzo and Kiyo Aoshima Memorial Funds, Japan"},{"name":"Taiwan Brain Disease Foundation, Taipei, Taiwan"},{"name":"Tseng-Lien Lin Foundation, Taichung, Taiwan"},{"name":"NRPB Stroke Clinical Trial Consortium","award":["MOST 105-2325-B-039-003"],"award-info":[{"award-number":["MOST 105-2325-B-039-003"]}]},{"name":"China Medical University Hospital, Academia Sinica Taiwan Biobank Stroke Biosignature Project","award":["BM10501010037"],"award-info":[{"award-number":["BM10501010037"]}]},{"name":"Taiwan Ministry of Health and Welfare Clinical Trial and Research Center of Excellence","award":["MOHW106-TDU-B-212-113004"],"award-info":[{"award-number":["MOHW106-TDU-B-212-113004"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2019,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>Hepatic parasympathetic nerves branch off the vagus nerve. The vagal and hepatic nervous systems are important in liver physiological processes and some diseases such as diabetes, obesity, and liver cirrhosis. We were interested in vagal nerve integrity and subsequent diseases in peptic ulcer patients. Herein, we used National Health Insurance database in Taiwan and retrospectively assessed the risk of developing liver cirrhosis in peptic ulcer patients with and without complications by surgical treatments.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A cohort of 357\u00a0423 peptic ulcer patients without <jats:italic>Helicobacter pylori<\/jats:italic>, hepatitis B\/C virus infection, and alcoholism from 2001 to 2008 was established. A randomly selected cohort of 357\u00a0423 people without peptic ulcer that matched by age, gender, comorbidities, and index year was used for comparison. The risks of developing liver cirrhosis were assessed both in cohorts and in peptic ulcer patients with and without vagotomy at the end of 2011.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Peptic ulcer patients were with higher incidence of liver cirrhosis than those without peptic ulcer (2.63 <jats:italic>vs<\/jats:italic> 0.96 per 1000 person\u2010years) and with a 2.79\u2010fold adjusted hazard ratio (HR) (95% confidence interval\u00a0=\u00a02.66\u20132.93) based on the multivariable Cox proportional hazards regression analysis. Comparing with different peptic ulcer management strategies, the HR value for subsequent liver cirrhosis risk was the lowest in vagotomy group (HR\u00a0=\u00a00.46, 95% confidence interval\u00a0=\u00a00.33\u20130.64).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Peptic ulcer patients have an increased risk of developing liver cirrhosis. Moreover, there were association of vagotomy and decreased risk of subsequent liver cirrhosis in complicated peptic ulcer patients. However, further studies are warranted.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jgh.14440","type":"journal-article","created":{"date-parts":[[2018,8,13]],"date-time":"2018-08-13T01:10:46Z","timestamp":1534122646000},"page":"376-382","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["A comparative study of subsequent liver cirrhosis risk in non\u2010<i>Helicobacter pylori<\/i>\u2010infected peptic ulcer patients with and without vagotomy: An Asian population cohort study"],"prefix":"10.1111","volume":"34","author":[{"given":"Shih\u2010Chi","family":"Wu","sequence":"first","affiliation":[{"name":"Graduate Institute of Clinical Medical Science China Medical University College of Medicine  Taichung Taiwan"},{"name":"Trauma and Emergency Center China Medical University Hospital  Taichung Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William Tzu\u2010Liang","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Surgery China Medical University Hospital  Taichung Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chih\u2010Hsin","family":"Muo","sequence":"additional","affiliation":[{"name":"Management Office for Health Data China Medical University and Hospital  Taichung Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chung Y","family":"Hsu","sequence":"additional","affiliation":[{"name":"Graduate Institute of Clinical Medical Science China Medical University College of Medicine  Taichung Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,10,3]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2010.01.006"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/ar.a.20087"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.49.10.1643"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-1838(99)00086-7"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/ar.a.20081"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/ar.a.20092"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1566-0702(02)00135-2"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/cphy.c120035"},{"key":"e_1_2_5_10_1","first-page":"1728","article-title":"HSC and liver fibrosis","volume":"131","author":"Moreira RK","year":"2007","journal-title":"Arch. 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