{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,5]],"date-time":"2026-03-05T20:16:22Z","timestamp":1772741782612,"version":"3.50.1"},"reference-count":38,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2018,9,18]],"date-time":"2018-09-18T00:00:00Z","timestamp":1537228800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["U1501224"],"award-info":[{"award-number":["U1501224"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003453","name":"Natural Science Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2015A030313065"],"award-info":[{"award-number":["2015A030313065"]}],"id":[{"id":"10.13039\/501100003453","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2019,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Aim<\/jats:title><jats:p>\u03b2\u2010Arrestins (\u03b2\u2010arrs) are regulators and mediators of G protein\u2010coupled receptor signaling that are functionally involved in inflammation. Nuclear factor\u2010\u03baB p65 (NF\u2010\u03baBp65) activation has been observed early in the onset of pancreatitis. However, the effect of \u03b2\u2010arrs in acute pancreatitis (AP) is unclear. The aim of this study is to investigate whether \u03b2\u2010arrs are involved in AP through activation of NF\u2010\u03baBp65.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Acute pancreatitis was induced by either caerulein injection or choline\u2010deficient supplemented with ethionine diet (CDE). <jats:italic>\u03b2\u2010arr1<\/jats:italic> wild\u2010type and <jats:italic>\u03b2\u2010arr1<\/jats:italic> knockout mice were used in the experiment. The survival rate was calculated in the CDE model mice. Histological and western blot analyses were performed in the caerulein model. Inflammatory mediators were detected by real\u2010time polymerase chain reaction in the caerulein\u2010induced AP mice. Furthermore, AR42J and PANC\u20101 cell lines were used to further study the effects of \u03b2\u2010arr1 in caerulein\u2010induced pancreatic cells.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>\u03b2\u2010Arr1 but not \u03b2\u2010arr2 is significantly downregulated in caerulein\u2010induced AP in mice. Targeted deletion of \u03b2\u2010arr1 notably upregulated expression of the pancreatic inflammatory mediators including tumor necrosis factor \u03b1 and interleukin 1\u03b2 as well as interleukin 6 and aggravated AP in caerulein\u2010induced mice. \u03b2\u2010Arr1 deficiency increased mortality in mice with CDE\u2010induced AP. Further, \u03b2\u2010arr1 deficiency enhanced caerulein\u2010induced phosphorylation of NF\u2010\u03baBp65 both <jats:italic>in vivo<\/jats:italic> and <jats:italic>in vitro<\/jats:italic>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>\u03b2\u2010Arr1 alleviates AP via repression of NF\u2010\u03baBp65 activation, and it is a potentially therapeutic target for AP.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jgh.14450","type":"journal-article","created":{"date-parts":[[2018,8,25]],"date-time":"2018-08-25T13:38:55Z","timestamp":1535204335000},"page":"284-292","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["\u03b2\u2010Arrestin1 alleviates acute pancreatitis via repression of NF\u2010\u03baBp65 activation"],"prefix":"10.1111","volume":"34","author":[{"given":"Li","family":"Tao","sequence":"first","affiliation":[{"name":"Department of Gastroenterology The Third Affiliated Hospital of Sun Yat\u2010sen University  Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xianyi","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology The Third Affiliated Hospital of Sun Yat\u2010sen University  Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Siwei","family":"Tan","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology The Third Affiliated Hospital of Sun Yat\u2010sen University  Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yiming","family":"Lei","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology The Third Affiliated Hospital of Sun Yat\u2010sen University  Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huiling","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology The Third Affiliated Hospital of Sun Yat\u2010sen University  Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuwei","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology The Third Affiliated Hospital of Sun Yat\u2010sen University  Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fengping","family":"Zheng","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology The Third Affiliated Hospital of Sun Yat\u2010sen University  Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bin","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology The Third Affiliated Hospital of Sun Yat\u2010sen University  Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,9,18]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dld.2014.01.158"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2012-302779"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0046201"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.5946\/ce.2016.152"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2017.00216"},{"key":"e_1_2_6_7_1","doi-asserted-by":"crossref","unstructured":"WatanabeT KudoM StroberW.Immunopathogenesis of pancreatitis.Mucosal Immunol.2017;10:283\u2013298.","DOI":"10.1038\/mi.2016.101"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/MOG.0b013e328363e399"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines5020029"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/8095825"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms18112383"},{"key":"e_1_2_6_12_1","first-page":"17551","article-title":"Effects of diclofenac sodium and octreotide on treatment of caerulein\u2010induced acute pancreatitis in mice","volume":"8","author":"Ozer Cakir O","year":"2015","journal-title":"Int. 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