{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T23:28:26Z","timestamp":1792798106757,"version":"4.5.0"},"reference-count":38,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2018,9,21]],"date-time":"2018-09-21T00:00:00Z","timestamp":1537488000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Yokohama City University","award":["Basic research expenditure"],"award-info":[{"award-number":["Basic research expenditure"]}],"id":[{"id":"https:\/\/ror.org\/0135d1r83","id-type":"ROR","asserted-by":"crossref"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2019,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Aim<\/jats:title>\n                    <jats:p>\n                      This was a prospective, randomized trial of the efficacy of vonoprazan\u2010based and proton\u2010pump inhibitor\u2010based 7\u2010day triple regimens with amoxicillin and sitafloxacin as a third\u2010line therapy for eradicating\n                      <jats:italic>Helicobacter pylori<\/jats:italic>\n                      after failure of clarithromycin\u2010based and metronidazole\u2010based first\u2010line and second\u2010line therapy.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      We enrolled 63 patients positive for\n                      <jats:italic>H.\u00a0pylori<\/jats:italic>\n                      in whom first\u2010line and second\u2010line regimens for eradicating failed. Patients were randomized to the V\u2010AS group (vonoprazan 20\u2010mg bid, amoxicillin 750\u2010mg bid, and sitafloxacin 100\u2010mg bid for 7\u00a0days) or PPI\u2010AS group (esomeprazole 20\u2010mg bid, rabeprazole 10\u2010mg bid, or lansoprazole 30\u2010mg bid; amoxicillin 750\u2010mg bid; and sitafloxacin 100\u2010mg bid for 7\u00a0days). We assessed the outcome of eradication therapy using the\n                      <jats:sup>13<\/jats:sup>\n                      C\u2010urea breath test. We evaluated safety using patient questionnaires. This study was registered in the UMIN Clinical Trials Registry (UMIN000016336).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The intention\u2010to\u2010treat and per\u2010protocol eradication rates of V\u2010AS were 75.8% (95% confidence interval [CI]: 57.7\u201388.9%) and 83.3% (95% CI: 65.3\u201394.4%), respectively. The respective eradication rates of PPI\u2010AS were 53.3% (95% CI: 34.3\u201371.7%) and 57.1% (95% CI: 37.2\u201375.5%). In per\u2010protocol analyses, the eradication rate of the V\u2010AS group was significantly higher than that of the PPI\u2010AS group (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00.043); however, no significant differences were observed in intention\u2010to\u2010treat analyses (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00.071). Questionnaire scores did not differ significantly between the groups.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      The findings suggest that 7\u2010day triple therapy with vonoprazan, amoxicillin, and sitafloxacin is more effective than proton\u2010pump inhibitor, amoxicillin, and sitafloxacin as a third\u2010line regimen for eradicating\n                      <jats:italic>H.\u00a0pylori<\/jats:italic>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jgh.14456","type":"journal-article","created":{"date-parts":[[2018,8,28]],"date-time":"2018-08-28T07:38:14Z","timestamp":1535441894000},"page":"686-692","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":84,"title":["Randomized trial of vonoprazan\u2010based\n           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