{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T18:52:49Z","timestamp":1778698369429,"version":"3.51.4"},"reference-count":20,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2018,10,12]],"date-time":"2018-10-12T00:00:00Z","timestamp":1539302400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Longch Group Shanxi Shuang Ren Pharmaceuticals Co. Ltd"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2019,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Aim<\/jats:title><jats:p>The treatment of patients with functional dyspepsia (FD) remains unsatisfactory. We assessed the efficacy of Zhizhu Kuanzhong (ZZKZ) capsule, a traditional Chinese medicine formula, in patients with postprandial distress syndrome (PDS) of FD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The study was designed as a multicenter, randomized, double\u2010blinded, controlled clinical trial. Three\u2010hundred ninety\u2010two patients with PDS defined by Rome III criteria from 16 centers in China were randomly assigned to receive either ZZKZ or placebo. The proportion of the responders at 4\u00a0weeks after randomization was considered primary endpoint. Secondary endpoint was the symptom score reduction of each dyspeptic symptom relative to the baseline at 4\u00a0weeks after randomization in all subjects.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In terms of the primary endpoint, the proportion of the responders concerning the composite PDS symptom score was 38.8% and 54.7% in placebo group and ZZKZ group, respectively (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.003), in per protocol analysis at 4\u00a0weeks after randomization. Concerning the individual evaluated upper gastrointestinal symptoms, only postprandial fullness and early satiety showed significant difference in symptom score reduction at 4\u00a0weeks after randomization between placebo and ZZKZ groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Zhizhu Kuanzhong is superior to placebo in the treatment of PDS with FD. The exact mechanisms by which ZZKZ improves symptoms remain to be established (<jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/www.chictr.org.cn\/ChinCTR-TRC-14004714\">http:\/\/www.chictr.org.cn\/ChinCTR\u2010TRC\u201014004714<\/jats:ext-link>).<\/jats:p><\/jats:sec>","DOI":"10.1111\/jgh.14467","type":"journal-article","created":{"date-parts":[[2018,9,12]],"date-time":"2018-09-12T05:44:04Z","timestamp":1536731044000},"page":"526-531","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["The efficacy of oral Zhizhu Kuanzhong, a traditional Chinese medicine, in patients with postprandial distress syndrome"],"prefix":"10.1111","volume":"34","author":[{"given":"Yinglian","family":"Xiao","sequence":"first","affiliation":[{"name":"The First Affiliated Hospital, Sun Yat\u2010Sen University  Guangzhou Guangdong Province China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuwen","family":"Li","sequence":"additional","affiliation":[{"name":"The First Affiliated Hospital, Sun Yat\u2010Sen University  Guangzhou Guangdong Province China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianchang","family":"Shu","sequence":"additional","affiliation":[{"name":"Guangzhou Red Cross Hospital Affiliated to Medical College of Jinan University  Guangzhou Guangdong Province China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan","family":"Li","sequence":"additional","affiliation":[{"name":"The Second Affiliated Hospital of Chinese Medical University  Shenyang Liaoning Province China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianming","family":"Xu","sequence":"additional","affiliation":[{"name":"The First Affiliated Hospital of Anhui University  Hefei Anhui Province 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