{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,20]],"date-time":"2026-02-20T09:21:05Z","timestamp":1771579265251,"version":"3.50.1"},"reference-count":38,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2018,11,18]],"date-time":"2018-11-18T00:00:00Z","timestamp":1542499200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100011541","name":"Division of Cancer Epidemiology and Genetics, National Cancer Institute","doi-asserted-by":"publisher","award":["CA67488"],"award-info":[{"award-number":["CA67488"]}],"id":[{"id":"10.13039\/100011541","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2019,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Aim<\/jats:title><jats:p>Chronic <jats:italic>Helicobacter pylori<\/jats:italic> infection causes gastric mucosal inflammation as an important antecedent of gastric cancer. We aimed to evaluate associations of blood markers of inflammation with gastric intestinal metaplasia and dysplasia in <jats:italic>H.\u00a0pylori<\/jats:italic>\u2010infected individuals.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We compared pre\u2010treatment serum levels of immune\u2010related and inflammation\u2010related markers between 99 individuals with intestinal metaplasia or dysplasia and 75 control individuals with non\u2010atrophic gastritis within an <jats:italic>H.\u00a0pylori<\/jats:italic> eradication trial in Mexico. Serum levels of 28 markers measured with Luminex bead\u2010based assays were categorized in tertiles as low (T1), middle (T2), and high (T3). Logistic regression models were used to calculate age\u2010adjusted and sex\u2010adjusted odds ratios and 95% confidence intervals. All statistical tests were two\u2010sided, and significance values were adjusted for multiple comparisons using false discovery rate methods.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Five markers were nominally associated (<jats:italic>P<\/jats:italic><jats:sub>trend<\/jats:sub>\u00a0&lt;\u00a00.05) with the presence of advanced premalignant gastric lesions. Adjusted odds ratios (95% confidence interval) of T2 and T3 <jats:italic>versus<\/jats:italic> T1 were 4.09 (1.65\u201310.17) and 3.08 (1.23\u20137.68) for CCL3\/MIP1A, 3.21 (1.33\u20137.75) and 2.69 (1.10\u20136.57) for CCL20\/MIP3A levels, 1.79 (0.77\u20134.18) and 2.39 (1.02\u20135.60) for IL\u20101\u03b2, 1.34 (0.56\u20133.19) and 3.02 (1.29\u20137.12) for IL\u20104, and 1.07 (0.44\u20132.59) and 3.07 (1.32\u20137.14) for IL\u20105, respectively. Two (IL\u20104 and IL\u20105) of the five markers had false discovery rate adjusted <jats:italic>P<\/jats:italic><jats:sub>trend<\/jats:sub>\u00a0&lt;\u00a00.2.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our results suggest that certain Th2 and other cytokines may have a role in promoting carcinogenesis in the setting of <jats:italic>H.\u00a0pylori<\/jats:italic> infection. Additional research is needed to replicate these findings, extend to pre\u2010diagnostic samples, and elucidate the underlying mechanisms.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jgh.14518","type":"journal-article","created":{"date-parts":[[2018,10,25]],"date-time":"2018-10-25T03:44:58Z","timestamp":1540439098000},"page":"852-856","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Circulating inflammation\u2010related markers and advanced gastric premalignant lesions"],"prefix":"10.1111","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9412-2871","authenticated-orcid":false,"given":"Minkyo","family":"Song","sequence":"first","affiliation":[{"name":"Division of Cancer Epidemiology and Genetics National Cancer Institute  Rockville Maryland USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charles S","family":"Rabkin","sequence":"additional","affiliation":[{"name":"Division of Cancer Epidemiology and Genetics National Cancer Institute  Rockville Maryland USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Javier","family":"Torres","sequence":"additional","affiliation":[{"name":"Unidad de Investigaci\u00f3n en Enfermedades Infecciosas UMAE Pediatr\u00eda, CMN SXXI, Instituto Mexicano del Seguro Social  M\u00e9xico City Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Troy J","family":"Kemp","sequence":"additional","affiliation":[{"name":"HPV Immunology Laboratory, Frederick National Laboratory for Cancer Research Leidos Biomedical Research, Inc.  Frederick Maryland USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jovanny","family":"Zabaleta","sequence":"additional","affiliation":[{"name":"Department of Pediatrics and Stanley S. Scott Cancer Center, Louisiana Cancer Research Center Louisiana State University Health Sciences Center  New Orleans Louisiana USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ligia A","family":"Pinto","sequence":"additional","affiliation":[{"name":"HPV Immunology Laboratory, Frederick National Laboratory for Cancer Research Leidos Biomedical Research, Inc.  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