{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T17:40:55Z","timestamp":1776361255096,"version":"3.51.2"},"reference-count":24,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2018,11,14]],"date-time":"2018-11-14T00:00:00Z","timestamp":1542153600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Key Project from Beijing Municipal Science and Technology Commission","award":["D161100002716003"],"award-info":[{"award-number":["D161100002716003"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2019,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Aim<\/jats:title><jats:p>The impact of male sex and past hepatitis B virus (HBV) infection on survival of primary biliary cholangitis (PBC) are issues at discussion. The aim of the present study was to identify risk factors for transplant\u2010free survival (TRS) in Chinese PBC patients who received ursodeoxycholic acid (UDCA), with special focus on the impact of male sex and past HBV infection.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We followed up PBC patients who received UDCA at our institute between January 2000 and December 2017 until their death, liver transplantation, or censored on April 1, 2018, by interview and review of medical records. We used Cox proportional hazards model and Kaplan\u2013Meier method.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Out of 976 PBC patients, 732 UDCA\u2010treated patients (female\u00a0:\u00a0male\u00a0=\u00a06.2:1) with required clinical and laboratory data were enrolled in this study. The median follow\u2010up period were 4.8\u00a0years (interquartile range: 2.8\u20137.1\u00a0years). The overall 5\u2010, 10\u2010, and 15\u2010year TRS rates were 86.7% (95% CI: 83.8\u201388.1), 71.1% (95% CI: 65.0\u201377.2), and 59.2% (95% CI: 44.5\u201373.9), respectively. The survival was significantly worse for male patients and older patients (\u2265\u00a055\u00a0years) (log\u2010rank test: <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.05 for both). On multivariate analysis, male sex, cirrhosis, serum bilirubin, and serum albumin were independent predictors for TRS. There was no significant difference in survivals between patients with (<jats:italic>n<\/jats:italic>\u00a0=\u00a0167) and without (<jats:italic>n<\/jats:italic>\u00a0=\u00a0219) past HBV infection (log\u2010rank test: <jats:italic>P<\/jats:italic>\u00a0=\u00a00.293).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In this large Chinese cohort of UDCA\u2010treated PBC patients, male sex was associated with shorter survival, whereas past HBV infection was not associated with poorer outcome.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jgh.14521","type":"journal-article","created":{"date-parts":[[2018,10,26]],"date-time":"2018-10-26T12:55:05Z","timestamp":1540558505000},"page":"1236-1241","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Prognosis of 732 ursodeoxycholic acid\u2010treated patients with primary biliary cholangitis: A single center follow\u2010up study from China"],"prefix":"10.1111","volume":"34","author":[{"given":"Sha","family":"Chen","sequence":"first","affiliation":[{"name":"Liver Research Center Beijing Friendship Hospital, Capital Medical University  Beijing China"},{"name":"Beijing Key Laboratory of Translational Medicine on Cirrhosis Capital Medical University  Beijing China"},{"name":"National Clinical Research Center for Digestive Diseases Capital Medical University  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weijia","family":"Duan","sequence":"additional","affiliation":[{"name":"Liver Research Center Beijing Friendship Hospital, Capital Medical University  Beijing China"},{"name":"Beijing Key Laboratory of Translational Medicine on Cirrhosis Capital Medical University  Beijing China"},{"name":"National Clinical Research Center for Digestive Diseases Capital Medical University  Beijing 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Hospital, Capital Medical University  Beijing China"},{"name":"Beijing Key Laboratory of Translational Medicine on Cirrhosis Capital Medical University  Beijing China"},{"name":"National Clinical Research Center for Digestive Diseases Capital Medical University  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qiuju","family":"Tian","sequence":"additional","affiliation":[{"name":"Liver Research Center Beijing Friendship Hospital, Capital Medical University  Beijing China"},{"name":"Beijing Key Laboratory of Translational Medicine on Cirrhosis Capital Medical University  Beijing China"},{"name":"National Clinical Research Center for Digestive Diseases Capital Medical University  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qianyi","family":"Wang","sequence":"additional","affiliation":[{"name":"Liver Research Center Beijing Friendship Hospital, Capital Medical University  Beijing China"},{"name":"Beijing Key Laboratory of 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