{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T14:34:20Z","timestamp":1787495660746,"version":"build-2736575974"},"reference-count":35,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2018,12,17]],"date-time":"2018-12-17T00:00:00Z","timestamp":1545004800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2019,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Aim<\/jats:title>\n                    <jats:p>\n                      Owing to wide\u2010spread use, low\u2010dose aspirin (LDA) produces a substantial amount of peptic ulcer disease. Current guidelines are ambivalent about the need for\n                      <jats:italic>Helicobacter pylori<\/jats:italic>\n                      eradication to protect against LDA ulcers. This study aimed to determine, through meta\u2010analysis, if (and by how much) infection alters the baseline risk of peptic ulcers during LDA therapy.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Literature screening was performed in MEDLINE and EMBASE from inception to May 2018. Original studies reporting prevalence or incidence of uncomplicated ulcers in LDA users were included. Ulcer endpoints needed to be specified separately, according to\n                      <jats:italic>H.\u00a0pylori<\/jats:italic>\n                      infection status. Meta\u2010analysis was performed in MIX 2.0 Pro.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Ten cross\u2010sectional studies and seven randomized controlled trials were included (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a05964). The pooled odds ratios with 95% confidence intervals (CI) for the risk of LDA ulcers in\n                      <jats:italic>H.\u00a0pylori<\/jats:italic>\n                      \u2010positive\n                      <jats:italic>versus H.\u00a0pylori<\/jats:italic>\n                      \u2010negative individuals were 1.68 (95%CI 1.40\u20132.02) and 1.65 (95%CI 1.29\u20132.08) under fixed\u2010effects and random\u2010effects models, respectively. Heterogeneity among studies was minimal (\n                      <jats:italic>I<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      \u00a0=\u00a026.9%). After adjusting for the protective effects of antisecretory drugs, the odds ratios increased to 1.94 (95%CI 1.54\u20132.46).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      This analysis suggests that\n                      <jats:italic>H.\u00a0pylori<\/jats:italic>\n                      increases the risk of LDA ulcers by almost 70% in a population where some were taking proton pump inhibitors and\/or other acid suppressants. Without antisecretory drugs, the risk almost doubles. Clinically, these findings may support the use of a test\u2010and\u2010treat approach to\n                      <jats:italic>H.\u00a0pylori<\/jats:italic>\n                      in LDA users, particularly those already at higher risk of developing peptic ulcers.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jgh.14539","type":"journal-article","created":{"date-parts":[[2018,11,8]],"date-time":"2018-11-08T15:12:45Z","timestamp":1541689965000},"page":"517-525","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["Helicobacter pylori and low\u2010dose aspirin ulcer risk: A meta\u2010analysis"],"prefix":"10.1111","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7803-3169","authenticated-orcid":false,"given":"Gino L","family":"Sarri","sequence":"first","affiliation":[{"name":"Melbourne School of Medicine University of Melbourne  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6116-6595","authenticated-orcid":false,"given":"Sam E","family":"Grigg","sequence":"additional","affiliation":[{"name":"Melbourne School of Medicine University of Melbourne  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neville D","family":"Yeomans","sequence":"additional","affiliation":[{"name":"Melbourne School of Medicine University of Melbourne  Melbourne Victoria Australia"},{"name":"Office for Research Austin Health  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,12,17]]},"reference":[{"key":"e_1_2_6_2_1","unstructured":"Cancer Council AustraliaColorectal Cancer Guidelines Working Party. 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