{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T13:57:10Z","timestamp":1790517430045,"version":"4.1.0"},"reference-count":23,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2018,12,18]],"date-time":"2018-12-18T00:00:00Z","timestamp":1545091200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001711","name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung","doi-asserted-by":"publisher","award":["320030_166670"],"award-info":[{"award-number":["320030_166670"]}],"id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2019,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Aim<\/jats:title><jats:p>Functional dyspepsia (FD) is a common disorder of gut\u2013brain interaction with incompletely understood pathophysiology. Consequently, heterogeneous expert opinions on diagnostic tests and assessment of treatment efficacies exist. So far, no consensus about the most relevant diagnostic and outcome tool has been reached. In this study, we aimed to analyze the significance of a combined lactulose hydrogen breath test (LHBT) and liquid meal, yet representing a standardized test in irritable bowel syndrome (IBS), in FD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We analyzed data of 146 FD, 204 IBS patients, and 50 healthy volunteers (HV). All patients underwent LHBT with a meal\u2010drink consisting of 30\u2010g Lactulose and 400\u2010mL Ensure\u00ae. Effect of abdominal symptom generation in FD\/IBS compared with HV was assessed on a patient\u2010reported Likert\u2010scale.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There was a significant difference between FD\/IBS patients and HV in LHBT\u2010induced abdominal pain (odds ratio [OR] 246.9, 95% confidence interval [CI] 26.6\u20132290.7; OR 161.2, 95% CI 16.9\u20131534.8), abdominal bloating (OR 384.8, 95% CI 92.9\u20132135.4; OR 524.1, 95% CI 114.7\u20133432.3), borborygmi (OR 9.9, 95% CI 2.2\u201346.9; OR 17.7, 95% CI 4.7\u201367.4), nausea only in FD (OR 174.4, 95% CI 15.5\u20135375.5), and diarrhea in IBS only (OR 25.8, 95% CI 2.0\u20137012.6). Hydrogen production was not significantly different in FD\/IBS and HV.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In this study, we demonstrated significant differences in postprandial symptom generation in FD and IBS compared with HV after LHBT. This does not only allow us to discriminate FD\/IBS from HV but may also represent a diagnostic and monitoring tool for FD\/IBS in the future, including monitoring of treatment effects.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jgh.14551","type":"journal-article","created":{"date-parts":[[2018,12,18]],"date-time":"2018-12-18T23:16:03Z","timestamp":1545174963000},"page":"843-851","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Differentiation of functional gastrointestinal disorders from healthy volunteers by lactulose hydrogen breath test and test meal"],"prefix":"10.1111","volume":"34","author":[{"given":"Valeria","family":"Schindler","sequence":"first","affiliation":[{"name":"Division of Gastroenterology and Hepatology University Hospital Z\u00fcrich  Z\u00fcrich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"St\u00e9phanie","family":"Giezendanner","sequence":"additional","affiliation":[{"name":"Centre for Primary Health Care University of Basel  Basel Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon","family":"B\u00fctikofer","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology University Hospital Z\u00fcrich  Z\u00fcrich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fritz","family":"Murray","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology University Hospital Z\u00fcrich  Z\u00fcrich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Runggaldier","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology University Hospital Z\u00fcrich  Z\u00fcrich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Larissa","family":"Schnurre","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology University Hospital Z\u00fcrich  Z\u00fcrich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annina","family":"Zweig","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology University Hospital Z\u00fcrich  Z\u00fcrich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Fried","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology University Hospital Z\u00fcrich  Z\u00fcrich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Pohl","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology University Hospital Z\u00fcrich  Z\u00fcrich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,12,18]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2016.02.011"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2007.137125"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40271-016-0164-1"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2017.46"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2015.09.039"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2018.04.034"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2005.11.059"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2013.75"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2016.499"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.12793"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2013.05.018"},{"key":"e_1_2_6_13_1","first-page":"G146","article-title":"Duodenal pH governs interdigestive motility in humans","volume":"268","author":"Woodtli W","year":"1995","journal-title":"Am. 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