{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,17]],"date-time":"2025-09-17T16:21:49Z","timestamp":1758126109244},"reference-count":23,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2018,12,16]],"date-time":"2018-12-16T00:00:00Z","timestamp":1544918400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2019,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Aim<\/jats:title><jats:p>There are no established guidelines on screening strategies for persons with a family history of colorectal cancer (CRC) in Korea. We aimed to evaluate the age\u2010specific risk of colorectal neoplasia according to family history of CRC.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Participants who underwent screening colonoscopy were included. Age\u2010specific prevalence of non\u2010advanced adenoma (NAA) and advanced colorectal neoplasia (ACRN) was calculated according to family history of CRC.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among 35\u00a0997 participants, 1339 (3.7%) had a family history of CRC in first\u2010degree relatives. A family history of CRC was an independent risk factor for NAA (adjusted odds ratio [AOR] 1.33, 95% confidence interval [CI] 1.16\u20131.52). In the subgroup analysis by age, family history of CRC was a risk factor for NAA in the 50\u201359 and \u2265\u00a060\u00a0years groups (AOR [95% CI]: 1.42 [1.04\u20131.91] and 2.33 [1.34\u20134.09], respectively), but not in the 30\u201339 and 40\u201349\u00a0years groups. In the curve of age\u2010specific prevalence of NAA, the gap of the prevalence between the family history and non\u2010family history groups began to widen after the mid\u201050s. In cases of ACRN, a family history of CRC was not a risk factor in the entire age group (AOR 1.16, 95% CI 0.75\u20131.70). In the curve of age\u2010specific prevalence of ACRN, however, the gap of the prevalence between the family history and non\u2010family history groups began to widen after the early 60s.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Although a family history of CRC is a risk factor for NAA, it may affect NAA development from the mid\u201050s and ACRN development from the early 60s.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jgh.14553","type":"journal-article","created":{"date-parts":[[2018,11,21]],"date-time":"2018-11-21T21:33:24Z","timestamp":1542836004000},"page":"537-543","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Impact of family history of colorectal cancer on age\u2010specific prevalence of colorectal neoplasia"],"prefix":"10.1111","volume":"34","author":[{"given":"Chan Hyuk","family":"Park","sequence":"first","affiliation":[{"name":"Department of Internal Medicine Hanyang University Guri Hospital, Hanyang University College of Medicine  Guri Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nam Hee","family":"Kim","sequence":"additional","affiliation":[{"name":"Preventive Health Care, Kangbuk Samsung Hospital Sungkyunkwan University School of Medicine  Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jung Ho","family":"Park","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Department of Internal Medicine, Kangbuk Samsung Hospital Sungkyunkwan University School of Medicine  Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dong Il","family":"Park","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Department of Internal Medicine, Kangbuk Samsung Hospital Sungkyunkwan University School of Medicine  Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chong Il","family":"Sohn","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Department of Internal Medicine, Kangbuk Samsung Hospital Sungkyunkwan University School of Medicine  Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoon Suk","family":"Jung","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Department of Internal Medicine, Kangbuk Samsung Hospital Sungkyunkwan University School of Medicine  Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,12,16]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199412223312501"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2001.04677.x"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2005.09.023"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2017.174"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2013-306503"},{"key":"e_1_2_5_7_1","unstructured":"Korean Statistical Information Service Cancer incident cases and incidence rates by site (24 items) sex age group Avilable at:http:\/\/kosis.kr\/statHtml\/statHtml.do?orgId=117&tblId=DT_117N_A00023&conn_path=I2&language=en(Accessed August 12 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