{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T18:49:27Z","timestamp":1773341367273,"version":"3.50.1"},"reference-count":33,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2019,1,14]],"date-time":"2019-01-14T00:00:00Z","timestamp":1547424000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2019,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Aim<\/jats:title><jats:p>The chemopreventive effect of aspirin in colorectal cancer (CRC) is well studied, but its benefit in patients after CRC diagnosis and surgery is unclear. This study aims to investigate the effects of low\u2010dose aspirin use in mortality among CRC patients after surgery.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients were analyzed in two cohorts: (i) patients taking aspirin before CRC diagnosis and continued or discontinued aspirin after surgery and (ii) patients, who never used aspirin before CRC diagnosis, received or did not receive aspirin after surgery. CRC\u2010related mortality and all\u2010cause mortality were the primary and secondary outcomes. Sub\u2010distribution hazard ratio (SHR) for competing\u2010risk CRC mortality was fitted to adjust for other causes of death; hazard ratio (HR) was used to compare all\u2010cause mortality.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 13\u00a0528 CRC patients were included. Among 3292 patients with regular aspirin use before CRC diagnosis, 2658 (80.7%) continued aspirin and 634 (19.3%) discontinued aspirin after surgery. Continuous use of aspirin significantly reduced CRC\u2010related mortality (SHR: 0.69, 95% confidence interval [CI]: 0.59\u20130.81) and all\u2010cause mortality (HR: 0.61, 95% CI: 0.55\u20130.68). Among 10\u00a0236 patients who did not use aspirin before CRC diagnosis, 1054 patients (10.3%) received aspirin after surgery and 9182 (89.7%) did not. Aspirin initiated after surgery reduced CRC\u2010related mortality (SHR: 0.88, 95% CI: 0.80\u20130.98) and all\u2010cause mortality (HR: 0.87, 95% CI: 0.81\u20130.94).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Irrespective of aspirin use before surgery for CRC, low\u2010dose aspirin after surgery lowers risk of both CRC\u2010related mortality and overall mortality.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jgh.14562","type":"journal-article","created":{"date-parts":[[2018,12,5]],"date-time":"2018-12-05T07:33:33Z","timestamp":1543995213000},"page":"1027-1034","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Low\u2010dose aspirin can reduce colorectal cancer mortality after surgery: A 10\u2010year follow\u2010up of 13\u00a0528 colorectal cancer patients"],"prefix":"10.1111","volume":"34","author":[{"given":"Joseph J Y","family":"Sung","sequence":"first","affiliation":[{"name":"The Institute of Digestive Disease, Faculty of Medicine The Chinese University of Hong Kong  Shatin Hong Kong"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jason M W","family":"Ho","sequence":"additional","affiliation":[{"name":"Jockey Club School of Public Health and Primary Care The Chinese University of Hong Kong  Shatin Hong Kong"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Felix C H","family":"Chan","sequence":"additional","affiliation":[{"name":"Stanley Ho Big Data Decision Analytic Research Centre The Chinese University of Hong Kong  Shatin Hong Kong"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5580-7686","authenticated-orcid":false,"given":"Kelvin K F","family":"Tsoi","sequence":"additional","affiliation":[{"name":"Jockey Club School of Public Health and Primary Care The Chinese University of Hong Kong  Shatin Hong Kong"},{"name":"Stanley Ho Big Data Decision Analytic Research Centre The Chinese University of Hong Kong  Shatin Hong Kong"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,1,14]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21442"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(10)61543-7"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2009.1112"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa021735"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djn485"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(11)61049-0"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(07)60747-8"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(11)61720-0"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(12)70112-2"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc18-0368"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.7326\/M16-0577"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1080\/01621459.1999.10474144"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/dyr213"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.2307\/1937887"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa021633"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa021735"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(03)00887-4"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2015.09.010"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.2147\/OTT.S127335"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(10)62110-1"},{"key":"e_1_2_5_22_1","first-page":"7404","article-title":"Post\u2010operative aspirin use and colorectal cancer\u2010specific survival in patients with stage I\u2013III colorectal cancer","volume":"34","author":"Goh HH","year":"2014","journal-title":"Anticancer Res"},{"key":"e_1_2_5_23_1","article-title":"Aspirin and COX\u20102 inhibitor use in patients with stage III colon cancer","volume":"107","author":"Ng K","year":"2014","journal-title":"J. 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