{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,11]],"date-time":"2026-07-11T04:18:49Z","timestamp":1783743529357,"version":"3.55.0"},"reference-count":35,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2019,1,8]],"date-time":"2019-01-08T00:00:00Z","timestamp":1546905600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2019,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>It is unclear whether obesity increases the incidence of acute pancreatitis (AP) in the general population. Further, no study has prospectively examined the associations of the risk of AP by etiology with measured body mass index (BMI) values.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 512\u00a0928 Korean participants in routine health examinations during 2002\u20132003 were followed up until 2013 via linkage to national hospital discharge records to assess AP incidence. Multivariable\u2010adjusted hazard ratios were calculated using BMI measurements.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>During 10.5 mean years of follow\u2010up, 1656 persons developed AP (337 gallstone related and 1319 non\u2010gallstone related). Nonlinear associations were found: U\u2010curves for total and non\u2010gallstone\u2010related AP and a reverse L\u2010curve for gallstone\u2010related AP. Each 5\u00a0kg\/m<jats:sup>2<\/jats:sup> increment in BMI increased gallstone\u2010related AP by 123% (95% confidence interval\u00a0=\u00a048\u2013234%) and non\u2010gallstone\u2010related AP by 42% (9\u201384%) in the range \u2265\u00a025\u00a0kg\/m<jats:sup>2<\/jats:sup> (<jats:italic>P<\/jats:italic><jats:sub>heterogeneity<\/jats:sub>\u00a0=\u00a00.068). Obese persons had a doubled risk of gallstone\u2010related AP compared with normal\u2010weight persons. In the range &lt;\u00a025\u00a0kg\/m<jats:sup>2<\/jats:sup>, BMI had inverse association with non\u2010gallstone\u2010related AP but no association with gallstone\u2010related AP (<jats:italic>P<\/jats:italic><jats:sub>heterogeneity<\/jats:sub>\u00a0&lt;\u00a00.001). In subgroup analyses, for non\u2010gallstone\u2010related AP, hazard ratios per each 5\u00a0kg\/m<jats:sup>2<\/jats:sup> BMI increment were 0.50 (men), 0.73 (women), 0.46 (alcohol drinkers), 0.69 (alcohol non\u2010drinkers), 0.43 (ever smokers), and 0.73 (never smokers).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Gallstone\u2010related AP and non\u2010gallstone\u2010related AP have different nonlinear associations with BMI. Higher BMI increases the risk of both gallstone\u2010related AP and non\u2010gallstone\u2010related AP but more strongly for gallstone\u2010related AP. For non\u2010gallstone\u2010related AP, in the range &lt;\u00a025\u00a0kg\/m<jats:sup>2<\/jats:sup>, BMI has inverse associations that were stronger in men, current alcohol drinkers, and ever smokers than in their counterparts.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jgh.14570","type":"journal-article","created":{"date-parts":[[2018,12,15]],"date-time":"2018-12-15T05:40:10Z","timestamp":1544852410000},"page":"603-611","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Body mass index and the risk of acute pancreatitis by etiology: A prospective analysis of Korean National Screening Cohort"],"prefix":"10.1111","volume":"34","author":[{"given":"Ja Sung","family":"Choi","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, International St. Mary's Hospital Catholic Kwandong University  Gangneung Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6656-6205","authenticated-orcid":false,"given":"Sang\u2010Wook","family":"Yi","sequence":"additional","affiliation":[{"name":"Department of Preventive Medicine and Public Health, College of Medicine Catholic Kwandong University  Gangneung Korea"},{"name":"Institute for Clinical and Translational Research, College of Medicine Catholic Kwandong University  Gangneung Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin Woo","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, International St. Mary's Hospital Catholic Kwandong University  Gangneung Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sangheun","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, International St. Mary's Hospital Catholic Kwandong University  Gangneung Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9197-1184","authenticated-orcid":false,"given":"Seok\u2010Hoo","family":"Jeong","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, International St. Mary's Hospital Catholic Kwandong University  Gangneung Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jee\u2010Jeon","family":"Yi","sequence":"additional","affiliation":[{"name":"Institute for Occupational and Environmental Health Catholic Kwandong University  Gangneung Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ki Jun","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, International St. Mary's Hospital Catholic Kwandong University  Gangneung Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,1,8]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2012.08.002"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1505202"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPA.0000000000000123"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2013.01.068"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.26563"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2015.343"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPA.0000000000000137"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1159\/000114868"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2012.381"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.annepidem.2014.12.010"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.25.2.298"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1155\/2010\/482950"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwx193"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/ijo.2010.148"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/dyv138"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1080\/003655202762671369"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1159\/000331773"},{"key":"e_1_2_6_19_1","first-page":"1","volume-title":"Validity of the Diagnosis of Acute Myocardial Infarction in Korean National Medical Health Insurance Claims Data. 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