{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T19:30:49Z","timestamp":1790019049888,"version":"4.0.1"},"reference-count":29,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2019,1,6]],"date-time":"2019-01-06T00:00:00Z","timestamp":1546732800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2019,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Aim<\/jats:title><jats:p>The relationship between a family history of colorectal cancer (CRC) and the risk of metachronous colorectal neoplasia (CRN) following polypectomy remains unknown. We aimed to compare the risk of metachronous CRN according to CRC family history in groups of patients aged &lt;\u00a050 and \u2265\u00a050\u00a0years.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We studied patients who underwent \u2265\u00a01 adenoma removal between 2010 and 2014 and follow\u2010up surveillance colonoscopic examinations until 2017.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among the 9866 patients studied, 544 (5.5%) had \u2265\u00a01 first\u2010degree relatives (FDRs) affected by CRC. In patients aged &lt;\u00a050\u00a0years (<jats:italic>n<\/jats:italic>\u00a0=\u00a07787), as compared with having no family history of CRC, a positive family history in any FDR (hazard ratio [HR] 1.37, 95% confidence interval [CI] 1.16\u20131.62), a father (HR 1.35, 95% CI 1.09\u20131.68), or a mother (HR 1.32, 95% CI 1.005\u20131.74) was associated with an increased risk of metachronous CRN after adjusting for confounding factors. However, in patients aged \u2265\u00a050\u00a0years (<jats:italic>n<\/jats:italic>\u00a0=\u00a02079), there was no significant association between having an FDR with CRC and the risk of metachronous CRN. For metachronous advanced CRN, the association between its risk and family history of CRC was not observed in either the &lt;\u00a050\u00a0years or \u2265\u00a050\u00a0years of age group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Having an FDR with CRC at a young age (&lt;\u00a050\u00a0years) appears to be closely related to the risk of metachronous CRN. However, considering that the risk of metachronous advanced CRN did not depend on CRC family history, the interval of post\u2010polypectomy surveillance colonoscopy may not need to be adjusted depending on CRC family history.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jgh.14578","type":"journal-article","created":{"date-parts":[[2018,12,16]],"date-time":"2018-12-16T22:29:48Z","timestamp":1544999388000},"page":"383-389","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Association between family history of colorectal cancer and the risk of metachronous colorectal neoplasia following polypectomy in patients aged &lt;\u00a050\u00a0years"],"prefix":"10.1111","volume":"34","author":[{"given":"Nam Hee","family":"Kim","sequence":"first","affiliation":[{"name":"Preventive Healthcare Center, Kangbuk Samsung Hospital Sungkyunkwan University School of Medicine  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoon Suk","family":"Jung","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Department of Internal Medicine, Kangbuk Samsung Hospital Sungkyunkwan University School of Medicine  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jung Ho","family":"Park","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Department of Internal Medicine, Kangbuk Samsung Hospital Sungkyunkwan University School of Medicine  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong Il","family":"Park","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Department of Internal Medicine, Kangbuk Samsung Hospital Sungkyunkwan University School of Medicine  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chong Il","family":"Sohn","sequence":"additional","affiliation":[{"name":"Division 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