{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T07:28:14Z","timestamp":1791444494212,"version":"4.3.3"},"reference-count":41,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2019,2,17]],"date-time":"2019-02-17T00:00:00Z","timestamp":1550361600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003453","name":"Natural Science Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2017A030313646"],"award-info":[{"award-number":["2017A030313646"]}],"id":[{"id":"10.13039\/501100003453","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2019,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Aim<\/jats:title>\n                    <jats:p>Nonsteroidal anti\u2010inflammatory drugs (NSAIDs) are a major cause of gastric mucosal lesions. In China, teprenone is frequently prescribed as a mucoprotective agent, but the literature regarding their efficacy is limited. Our purpose was to address the effects of teprenone on long\u2010term NSAID\u2010associated gastric mucosal lesions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      This study examined 369 patients taking NSAIDs for at least 12\u00a0weeks. Patients without gastroduodenal ulcer and without\n                      <jats:italic>Helicobacter pylori<\/jats:italic>\n                      infection on endoscopy at baseline were randomized to receive either NSAID plus teprenone (150\u00a0mg\/day) or NSAID only for 12\u00a0weeks. Lanza scores were examined using endoscopy before and after treatment, and dyspeptic symptom scores are also analyzed.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 158 patients were randomized to the teprenone group (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a074) or the control group (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a084) for 12\u00a0weeks. Seventy\u2010one of patients in the teprenone group and 79 of patients in the control group were analyzed finally. After treatment, the Lanza scores and dyspeptic symptom scores decreased significantly in the teprenone group while increased in the control group (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a00.05). The changes of Lanza scores and dyspeptic symptom scores were higher in the teprenone group than in the control group (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a00.05). For subgroup analysis, the change in Lanza scores and dyspeptic symptom scores improved significantly in the teprenone group receiving long\u2010term low\u2010dose aspirin treatment, as well as in the teprenone group receiving other NSAIDs treatment (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a00.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      Teprenone may be an effective treatment choice of gastric mucosal injuries and dyspepsia symptoms in patients who used NSAIDs chronically without\n                      <jats:styled-content style=\"fixed-case\">\n                        <jats:italic>H.\u00a0pylori<\/jats:italic>\n                      <\/jats:styled-content>\n                      infection or history of gastroduodenal ulcer.\n                    <\/jats:p>\n               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