{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T10:40:10Z","timestamp":1761129610236},"reference-count":42,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2019,2,17]],"date-time":"2019-02-17T00:00:00Z","timestamp":1550361600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2019,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Aim<\/jats:title><jats:p>Data regarding the comparative effectiveness and safety of sofosbuvir (SOF) in combination with ribavirin (RBV), daclatasvir (DCV), or ledipasvir (LDV) for hepatitis C virus genotype 2 (HCV\u20102) patients were limited. We aimed to evaluate the performance of these regimens in Taiwan.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>One hundred eighty\u2010seven HCV\u20102 patients with compensated liver diseases receiving SOF in combination with RBV (<jats:italic>n<\/jats:italic>\u00a0=\u00a082), DCV (<jats:italic>n<\/jats:italic>\u00a0=\u00a066), or LDV (<jats:italic>n<\/jats:italic>\u00a0=\u00a039) for 12\u00a0weeks were retrospectively enrolled. The effectiveness was determined by sustained virologic response 12\u00a0weeks off therapy (SVR<jats:sub>12<\/jats:sub>). The patient characteristics potentially related to SVR<jats:sub>12<\/jats:sub> were compared. The safety profiles and laboratory abnormalities were assessed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The SVR<jats:sub>12<\/jats:sub> rates were 93.9% (95% confidence interval [CI]: 86.5\u201397.4%), 98.5% (95% CI: 91.9\u201399.7%), and 100% (95% CI: 91.0\u2013100%) in patients receiving SOF combined with RBV, DCV, and LDV, respectively. All patients tolerated treatment well. The stratified SVR<jats:sub>12<\/jats:sub> rates were comparable regardless of baseline characteristics or week 4 viral decline among these regimens. Six (3.2%) patients had serious adverse events which were not related to treatment. The rates of fatigue, pruritus, and anemia tended to be higher in patients receiving RBV (22.0%, 19.5%, and 8.5%) combination than those receiving DCV (10.6%, 6.1%, and 1.5%) or LDV (10.3%, 5.1%, and 0%) combination.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Sofosbuvir in combination with RBV, DCV, or LDV for 12\u00a0weeks is effective and well\u2010tolerated for HCV\u20102 patients. Compared with DCV or LDV combination, the risks of fatigue, pruritus, and anemia are higher in patients receiving RBV combination.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jgh.14615","type":"journal-article","created":{"date-parts":[[2019,1,29]],"date-time":"2019-01-29T16:49:44Z","timestamp":1548780584000},"page":"1620-1625","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Sofosbuvir\u2010based direct acting antiviral therapies for patients with hepatitis C virus genotype 2 infection"],"prefix":"10.1111","volume":"34","author":[{"given":"Chen\u2010Hua","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Internal Medicine National Taiwan University Hospital  Taipei Taiwan"},{"name":"Hepatitis Research Center National Taiwan University Hospital  Taipei Taiwan"},{"name":"Department of Internal Medicine National Taiwan University Hospital, Yun\u2010Lin Branch  Douliou Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tung\u2010Hung","family":"Su","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine National Taiwan University Hospital  Taipei Taiwan"},{"name":"Hepatitis Research Center National Taiwan University Hospital  Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chun\u2010Jen","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine National Taiwan University Hospital  Taipei Taiwan"},{"name":"Hepatitis Research Center National Taiwan University Hospital  Taipei Taiwan"},{"name":"Graduate Institute of Clinical Medicine National Taiwan University College of Medicine  Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chun\u2010Ming","family":"Hong","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine National Taiwan University Hospital  Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hung\u2010Chih","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine National Taiwan University Hospital  Taipei Taiwan"},{"name":"Hepatitis Research Center National Taiwan University Hospital  Taipei Taiwan"},{"name":"Department of Microbiology National Taiwan University College of Medicine  Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tai\u2010Chung","family":"Tseng","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine National Taiwan University Hospital  Taipei Taiwan"},{"name":"Hepatitis Research Center National Taiwan University Hospital  Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pei\u2010Jer","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine National Taiwan University Hospital  Taipei Taiwan"},{"name":"Hepatitis Research Center National Taiwan University Hospital  Taipei Taiwan"},{"name":"Graduate Institute of Clinical Medicine National Taiwan University College of Medicine  Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ding\u2010Shinn","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine National Taiwan University Hospital  Taipei Taiwan"},{"name":"Hepatitis Research Center National Taiwan University Hospital  Taipei Taiwan"},{"name":"Genomics Research Center, Academia Sinica  Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jia\u2010Horng","family":"Kao","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine National Taiwan University Hospital  Taipei Taiwan"},{"name":"Hepatitis Research Center National Taiwan University Hospital  Taipei Taiwan"},{"name":"Graduate Institute of Clinical Medicine National Taiwan University College of Medicine  Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,2,17]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2468-1253(16)30181-9"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jfma.2015.06.012"},{"key":"e_1_2_6_4_1","first-page":"2051","article-title":"Nanomedicines in the treatment of hepatitis C virus infection in Asian patients: optimizing use of peginterferon alfa","volume":"9","author":"Liu CH","year":"2014","journal-title":"Int. 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