{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T00:54:47Z","timestamp":1767833687797,"version":"3.49.0"},"reference-count":24,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2019,2,17]],"date-time":"2019-02-17T00:00:00Z","timestamp":1550361600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2019,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Aim<\/jats:title><jats:p>Optimal treatment modalities for each of the three subtypes of achalasia are still under debate. Differences in prognosis and long\u2010term outcomes between peroral endoscopic myotomy (POEM) and balloon dilation (BD) are also unclear. We aimed to compare the treatment outcomes of BD and POEM in each subtype of achalasia by using information from the manometry database of a tertiary referral center in Korea.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Data from 5207 esophageal manometry procedures performed between 1989 and 2016 were analyzed. The medical records and results of esophagography and esophagogastroduodenoscopy were also reviewed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We identified 264 patients (116 men and 148 women) with diagnosis of achalasia during the study period. POEM and BD were carried out on 64 and 177 patients, respectively. There was a significant difference in the time to relapse between the POEM group and the BD group (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.002). At the 24\u2010month follow\u2010up, the clinical success rates of POEM and BD were 91.8% and 68.0%, respectively. The hazard ratio of symptom return was 6.54 for BD compared with POEM (95% confidence interval 2.12\u201320.22, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.001). After a follow\u2010up period of 24\u00a0months, the success rate of POEM was significantly higher than that of BD for all subtypes of achalasia. However, only that of types I and II was statistically significant (type 1: 92.0% <jats:italic>vs<\/jats:italic> 51.1%, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.004; type 2: 92.3% <jats:italic>vs<\/jats:italic> 59.8%, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.007; and type3: 91.7% <jats:italic>vs<\/jats:italic> 55.6%, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.051).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Peroral endoscopic myotomy was more effective than BD in providing mid\u2010long\u2010term remission in patients with all manometric subtypes of achalasia.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jgh.14616","type":"journal-article","created":{"date-parts":[[2019,1,30]],"date-time":"2019-01-30T01:01:42Z","timestamp":1548810102000},"page":"659-665","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":34,"title":["Superior clinical outcomes of peroral endoscopic myotomy compared with balloon dilation in all achalasia subtypes"],"prefix":"10.1111","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7652-2580","authenticated-orcid":false,"given":"Ga Hee","family":"Kim","sequence":"first","affiliation":[{"name":"Department of Gastroenterology, Asan Digestive Disease Research Institute Asan Medical Center, University of Ulsan College of Medicine  Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3771-3691","authenticated-orcid":false,"given":"Kee Wook","family":"Jung","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Asan Digestive Disease Research Institute Asan Medical Center, University of Ulsan College of Medicine  Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1281-5859","authenticated-orcid":false,"given":"Hwoon\u2010Yong","family":"Jung","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Asan Digestive Disease Research Institute Asan Medical Center, University of Ulsan College of Medicine  Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Min\u2010Ju","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Clinical Epidemiology and Biostatistics Asan Medical Center, University of Ulsan College of Medicine  Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6764-9099","authenticated-orcid":false,"given":"Hee Kyong","family":"Na","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Asan Digestive Disease Research Institute Asan Medical Center, University of Ulsan College of Medicine  Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0030-3744","authenticated-orcid":false,"given":"Ji Yong","family":"Ahn","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Asan Digestive Disease Research Institute Asan Medical Center, University of Ulsan College of Medicine  Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0778-7585","authenticated-orcid":false,"given":"Jeong Hoon","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Asan Digestive Disease Research Institute Asan Medical Center, University of Ulsan College of Medicine  Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4250-4683","authenticated-orcid":false,"given":"Do Hoon","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Asan Digestive Disease Research Institute Asan Medical Center, University of Ulsan College of Medicine  Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2517-4109","authenticated-orcid":false,"given":"Kee Don","family":"Choi","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Asan Digestive Disease Research Institute Asan Medical Center, University of Ulsan College of Medicine  Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3195-8794","authenticated-orcid":false,"given":"Ho June","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Asan Digestive Disease Research Institute Asan Medical Center, University of Ulsan College of Medicine  Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gin Hyug","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Asan Digestive Disease Research Institute Asan Medical Center, University of Ulsan College of 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