{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T01:31:19Z","timestamp":1747186279257,"version":"3.40.5"},"reference-count":46,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2019,2,25]],"date-time":"2019-02-25T00:00:00Z","timestamp":1551052800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Biomedical Development Center and Innovation & Incubation Center, MacKay Memorial Hospital","award":["BMD-105-008"],"award-info":[{"award-number":["BMD-105-008"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2019,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Aim<\/jats:title><jats:p>Several strategies have been proposed to increase the eradication rate of <jats:italic>Helicobacter pylori<\/jats:italic>. However, the widespread increasing resistance rates to current multiple\u2010dose oral antibiotic therapies call for alternative therapeutic approaches. We aim to develop a novel intraluminal therapy for <jats:italic>H.\u00a0pylori<\/jats:italic> infection (ILTHPI).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>From April 2017 to December 2017, 100 <jats:italic>H.\u00a0pylori<\/jats:italic>\u2010infected treatment\u2010na\u00efve patients with upper abdominal pain or discomfort underwent endoscopic examinations and concomitant ILTHPI, which comprised the control of intragastric pH, the irrigation of gastric mucosal surface with a mucolytic agent, and the application of single\u2010dose medicaments containing antibiotic powders. The safety profiles while conducting ILTHPI and adverse events after ILTHPI were evaluated. The success of eradication was assessed based on the result of the <jats:sup>13<\/jats:sup>C\u2010urea breath test 6\u00a0weeks after ILTHPI. In addition, a patient with successful ILTHPI was reconfirmed by a negative <jats:italic>H.\u00a0pylori<\/jats:italic> stool antigen test four to 6\u00a0months after ILTHPI to exclude short\u2010term recurrence.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>All the 100 enrolled patients completed the ILTHPI with good safety profiles and mild adverse events (6%). Five patients dropped out, and 51 of 95 patients (53.7%) achieved successful eradication immediately after endoscopic examinations. All 51 patients revealed negative stool <jats:italic>H.\u00a0pylori<\/jats:italic> antigen tests four to 6\u00a0months after successful ILTHPI. No short\u2010term recurrence was observed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>We have developed a novel therapeutic approach. With the ILTHPI, <jats:italic>H.\u00a0pylori<\/jats:italic> can be eradicated immediately by administrating a single\u2010dose regimen while conducting an endoscopic examination.<\/jats:p><\/jats:sec><jats:sec><jats:title>Clinical Trials Number<\/jats:title><jats:p>NCT03124420<\/jats:p><\/jats:sec>","DOI":"10.1111\/jgh.14627","type":"journal-article","created":{"date-parts":[[2019,2,8]],"date-time":"2019-02-08T09:34:36Z","timestamp":1549618476000},"page":"1337-1343","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Intraluminal therapy for <i>Helicobacter pylori<\/i> infection"],"prefix":"10.1111","volume":"34","author":[{"given":"Tai\u2010Cherng","family":"Liou","sequence":"first","affiliation":[{"name":"Division of Gastroenterology, Department of Internal Medicine MacKay Memorial Hospital  New Taipei City Taiwan"},{"name":"Division of Gastroenterology, Department of Internal Medicine MacKay Memorial Hospital  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