{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T13:05:20Z","timestamp":1788354320510,"version":"build-2803163510"},"reference-count":74,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2019,3,27]],"date-time":"2019-03-27T00:00:00Z","timestamp":1553644800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"National Research Foundation (NRF) of Korea grant for the Global Core Research Center (GCRC) funded by the Korean government","award":["2011-0030001"],"award-info":[{"award-number":["2011-0030001"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2019,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The cascade of gastric cancer, a leading cause of cancer incidence and mortality, is multifactorial. <jats:italic>Helicobacter pylori<\/jats:italic> (HP) infection plays a major role in gastric cancer (GC), and there has been an accumulation of data regarding the chemopreventive effect of HP eradication. However, it remains unclear how HP infection causes GC and how HP eradication prevents GC. To clarify this issue, the following approaches were performed in this review article. First, how HP\u2010induced atrophic gastritis (AG) and intestinal metaplasia (IM) provoke the development of GC is shown, followed by how long HP eradication takes to induce a reversible change in AG and IM. Second, epigenetic studies of <jats:italic>PTPN6<\/jats:italic>, <jats:italic>MOS<\/jats:italic>, <jats:italic>DCC<\/jats:italic>, <jats:italic>CRK<\/jats:italic>, and <jats:italic>VAV1<\/jats:italic> were performed in noncancerous gastric specimens in terms of HP status. Among these genes, <jats:italic>MOS<\/jats:italic> was found to be a possible surrogate marker for GC development. HP eradication decreased aberrant DNA methylation in a gene\u2010specific manner, and <jats:italic>MOS<\/jats:italic> played a role in metachronous gastric neoplasms. Third, transforming growth factor\u2010\u03b21 (TGF\u2010\u03b21) and TGF\u2010\u03b21\u2010induced epithelial\u2010mesenchymal transition (EMT) markers were investigated in gastric mucosa. HP infection triggered the TGF\u2010\u03b21\u2010induced EMT pathway and caused the emergence of GC stem cells, such as CD44v8\u201010. When HP was eradicated, these two pathways were inhibited. Finally, a 2222 cohort study showed that HP eradication significantly decreased the risk of noncardiac GC. Taken together, HP eradication is effective as a primary GC prevention method, and its underlying mechanism includes reversibility of AG and IM, methylation, EMT, and stem cells.<\/jats:p>","DOI":"10.1111\/jgh.14646","type":"journal-article","created":{"date-parts":[[2019,3,4]],"date-time":"2019-03-04T03:39:10Z","timestamp":1551670750000},"page":"1287-1295","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":48,"title":["Chemoprevention of gastric cancer by <scp><i>Helicobacter pylori<\/i><\/scp> eradication and its underlying mechanism"],"prefix":"10.1111","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9397-0406","authenticated-orcid":false,"given":"Nayoung","family":"Kim","sequence":"first","affiliation":[{"name":"Department of Internal Medicine Seoul National University Bundang Hospital  Seongnam South Korea"},{"name":"Department of Internal Medicine and Liver Research Institute Seoul National University College of Medicine  Seoul South Korea"},{"name":"Tumor Microenvironment Global Core Research Center Seoul National University  Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,3,27]]},"reference":[{"key":"e_1_2_3_2_1","first-page":"4737","article-title":"Gastric precancerous process in a high risk population: cohort follow\u2010up","volume":"50","author":"Correa P","year":"1990","journal-title":"Cancer Res."},{"key":"e_1_2_3_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gtc.2013.01.002"},{"key":"e_1_2_3_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1523-5378.2011.00859.x"},{"key":"e_1_2_3_5_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v7.i6.801"},{"key":"e_1_2_3_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.49.3.347"},{"key":"e_1_2_3_7_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.g3174"},{"key":"e_1_2_3_8_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2016.01.028"},{"key":"e_1_2_3_9_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.44.6.789"},{"key":"e_1_2_3_10_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2012-302240"},{"key":"e_1_2_3_11_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0183321"},{"key":"e_1_2_3_12_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1708423"},{"key":"e_1_2_3_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1746.2008.05314.x"},{"key":"e_1_2_3_14_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2017-015855"},{"key":"e_1_2_3_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/hel.12317"},{"key":"e_1_2_3_16_1","first-page":"192","article-title":"Gastric cancer: overview","volume":"44","author":"Piazuelo MB","year":"2013","journal-title":"Colomb. Med. (Cali)"},{"key":"e_1_2_3_17_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v12.i19.2979"},{"key":"e_1_2_3_18_1","doi-asserted-by":"publisher","DOI":"10.1177\/145749690609500403"},{"key":"e_1_2_3_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/path.2426"},{"key":"e_1_2_3_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1205921"},{"key":"e_1_2_3_21_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa001999"},{"key":"e_1_2_3_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2016.188"},{"key":"e_1_2_3_23_1","doi-asserted-by":"publisher","DOI":"10.15430\/JCP.2015.20.1.25"},{"key":"e_1_2_3_24_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.291.2.187"},{"key":"e_1_2_3_25_1","doi-asserted-by":"publisher","DOI":"10.1053\/gast.2000.8550"},{"key":"e_1_2_3_26_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2003.034629"},{"key":"e_1_2_3_27_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0034-1392090"},{"key":"e_1_2_3_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.12402"},{"key":"e_1_2_3_29_1","doi-asserted-by":"publisher","DOI":"10.4236\/ojpathology.2016.62012"},{"key":"e_1_2_3_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1523-5378.2011.00918.x"},{"key":"e_1_2_3_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2005.02582.x"},{"key":"e_1_2_3_32_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2009.07.060"},{"key":"e_1_2_3_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.14424"},{"key":"e_1_2_3_34_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2008.15"},{"key":"e_1_2_3_35_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.12380"},{"key":"e_1_2_3_36_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1099513"},{"key":"e_1_2_3_37_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2005.03.037"},{"key":"e_1_2_3_38_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1523-5378.2008.00604.x"},{"key":"e_1_2_3_39_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-016-4048-y"},{"key":"e_1_2_3_40_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2015-309252"},{"key":"e_1_2_3_41_1","doi-asserted-by":"publisher","DOI":"10.1111\/hel.12542"},{"key":"e_1_2_3_42_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-199600001-00003"},{"key":"e_1_2_3_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2007.01.029"},{"key":"e_1_2_3_44_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-981-287-706-2_23"},{"key":"e_1_2_3_45_1","doi-asserted-by":"publisher","DOI":"10.5483\/BMBRep.2007.40.2.142"},{"key":"e_1_2_3_46_1","first-page":"2847","article-title":"CpG island methylation in premalignant stages of gastric carcinoma","volume":"61","author":"Kang GH","year":"2001","journal-title":"Cancer Res."},{"key":"e_1_2_3_47_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1523-5378.2011.00838.x"},{"key":"e_1_2_3_48_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1349-7006.2010.01535.x"},{"key":"e_1_2_3_49_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2011.00021"},{"key":"e_1_2_3_50_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2012.07.009"},{"key":"e_1_2_3_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.micinf.2010.06.002"},{"key":"e_1_2_3_52_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2005.077776"},{"key":"e_1_2_3_53_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.28219"},{"key":"e_1_2_3_54_1","doi-asserted-by":"publisher","DOI":"10.5009\/gnl14472"},{"key":"e_1_2_3_55_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrm1835"},{"key":"e_1_2_3_56_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrm3758"},{"key":"e_1_2_3_57_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1349-7006.2007.00550.x"},{"key":"e_1_2_3_58_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-981-287-706-2_25"},{"key":"e_1_2_3_59_1","doi-asserted-by":"publisher","DOI":"10.1002\/emmm.200900043"},{"key":"e_1_2_3_60_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI39104"},{"key":"e_1_2_3_61_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1349-7006.2009.01419.x"},{"key":"e_1_2_3_62_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/8.1.93"},{"key":"e_1_2_3_63_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(17)31272-3"},{"key":"e_1_2_3_64_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10120-014-0412-9"},{"key":"e_1_2_3_65_1","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/bgv022"},{"key":"e_1_2_3_66_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature06187"},{"key":"e_1_2_3_67_1","doi-asserted-by":"publisher","DOI":"10.1111\/hel.12220"},{"key":"e_1_2_3_68_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2008.03.027"},{"key":"e_1_2_3_69_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2007.15.2603"},{"key":"e_1_2_3_70_1","first-page":"1","article-title":"Helicobacter pylori generates cells with cancer stem cell properties via epithelial\u2013mesenchymal transition\u2010like changes","volume":"8","author":"Bess\u00e8de E","year":"2013","journal-title":"Oncogene"},{"key":"e_1_2_3_71_1","doi-asserted-by":"publisher","DOI":"10.4291\/wjgp.v5.i3.366"},{"key":"e_1_2_3_72_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-13-2309"},{"key":"e_1_2_3_73_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature06196"},{"key":"e_1_2_3_74_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2015.02.049"},{"key":"e_1_2_3_75_1","doi-asserted-by":"publisher","DOI":"10.15430\/JCP.2016.21.4.279"}],"container-title":["Journal of Gastroenterology and Hepatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjgh.14646","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jgh.14646","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jgh.14646","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jgh.14646","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,10]],"date-time":"2023-09-10T06:24:38Z","timestamp":1694327078000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jgh.14646"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,3,27]]},"references-count":74,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2019,8]]}},"alternative-id":["10.1111\/jgh.14646"],"URL":"https:\/\/doi.org\/10.1111\/jgh.14646","archive":["Portico"],"relation":{},"ISSN":["0815-9319","1440-1746"],"issn-type":[{"value":"0815-9319","type":"print"},{"value":"1440-1746","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,3,27]]},"assertion":[{"value":"2019-01-05","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-03-01","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-03-27","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}